Results 141 to 150 of about 20,519,205 (284)

Estimation of the average treatment effect with variable selection and measurement error simultaneously addressed for potential confounders. [PDF]

Stat Methods Med Res, 2023
Yi GY, Chen LP.
europepmc   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Deep learning for causal inference using low birth weight in midwife-led continuity care intervention in north Shoa zone, Ethiopia

Frontiers in Artificial Intelligence
IntroductionLow birth weight (LBW), under 2,500 g, poses health risks, though not always requiring treatment. Early detection of high-risk pregnancies enables preventive care, improving outcomes for mother and baby.
Wudneh Ketema Moges, Wudneh Ketema Moges, Wudneh Ketema Moges, Awoke Seyoum Tegegne, Aweke A. Mitku, Aweke A. Mitku, Esubalew Tesfahun, Solomon Hailemeskel   +7 more
doaj   +1 more source

BOUNDING THE LOCAL AVERAGE TREATMENT EFFECT IN AN INSTRUMENTAL VARIABLE ANALYSIS OF ENGAGEMENT WITH A MOBILE INTERVENTION. [PDF]

Ann Appl Stat, 2022
Spieker AJ, Greevy RA, Nelson LA, Mayberry LS.   +3 more
europepmc   +1 more source

Average ART treatment effect on all-cause mortality among HIV and AIDS patients in Ghana.

, 2018
Average ART treatment effect on all-cause mortality among HIV and AIDS patients in Ghana.
Marijanatu Abdulai (5728658), Stephen Ayisi Addo (5245802), Samuel Bosomprah (95945), Chrisantus Tambaa (5728652), Duah Dwomoh (5728649), Ekow Wiah (5728655)   +5 more
core   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Sample average treatment effect on the treated (SATT) analysis using counterfactual explanation identifies BMT and SARS-CoV-2 vaccination as protective risk factors associated with COVID-19 severity and survival in patients with multiple myeloma. [PDF]

Blood Cancer J, 2023
Mitra AK, Mukherjee UK, Mazumder S, Madhira V, Bergquist T, Shao YR, Liu F, Song Q, Su J, Kumar S, Bates BA, Sharafeldin N, Topaloglu U, National COVID Cohort Collaborative Consortium.   +13 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Early COVID-19 Policies and Their Enduring Impact on Unemployment: Causal Evidence Through 2024

Statistics and Public Policy
In this article, we evaluate the lasting impact of the first-wave COVID-19 pandemic policies on unemployment during the post-first-wave period. Specifically, we analyze the causal effects of the Swedish first-wave policies relative to the Norwegian ones ...
Yongmiao Hong, Yinggang Zhou, Li Yin, Xiaoqin Wang   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source