Results 131 to 140 of about 4,704,446 (291)

Programme Evaluation of Unemployment Benefits in Japan: An Average Treatment Effect Approach [PDF]

Empirical results show that unemployment benefits (UB) recipients significantly change to worse job conditions with respect to wages and firm size, but change to better job conditions with respect to occupation, position, industry, and residence.
Yasushi Ohkusa
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Self-Attentive Quantile GAN With Causally Grounded Machine Learning for Vocal Biomarker Discovery in Parkinson’s Disease Detection

IEEE Access
Parkinson’s disease (PD) detection through voice analysis faces two fundamental challenges: traditional machine learning methods lack clinical interpretability due to their correlational nature, while existing causal inference approaches struggle ...
Meghana Sunil, V. Shravya, S. Nachiyappan   +2 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Estrogen Treatment Lowers the Risk of Complications in Menopausal Women with Mild Burn Injury

Medicina
Background and Objectives: Postmenopausal women are often treated with exogenous female hormones to alleviate physical symptoms and support mental health. We posit that women treated with estrogen fare better following burn injury. Materials and Methods:
Juquan Song, George Golovko, Kostiantyn Botnar, Amina El Ayadi, Kathleen L. Vincent, Steven E. Wolf   +5 more
doaj   +1 more source

Inverse probability weighted estimation for general missing data problems [PDF]

I study inverse probability weighted M-estimation under a general missing data scheme. The cases covered that do not previously appear in the literature include M-estimation with missing data due to a censored survival time, propensity score estimation ...
Jeffrey M. Wooldridge
core  

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Treatment Effect Heterogeneity in Theory and Practice [PDF]

Instrumental Variables (IV) methods identify internally valid causal effects for individuals whose treatment status is manipulable by the instrument at hand. Inference for other populations requires some sort of homogeneity assumption.
Joshua D. Angrist
core  

Estimating conditional average treatment effects with heteroscedasticity by model averaging and matching

Economics Letters
We propose a model averaging approach, combined with a partition and matching method to estimate the conditional average treatment effects under heteroskedastic error settings. The proposed approach has asymptotic optimality and consistency of weights and estimator. Numerical studies show that our method has good finite-sample performances.
Shi, Pengfei, Zhang, Xinyu, Zhong, Wei
openaire   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source