Results 81 to 90 of about 11,252,851 (310)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Limit cycles of the generalized Li'enard differential equation via averaging theory
Electronic Journal of Differential Equations, 2012 We apply the averaging theory of first and second order to a generalized Lienard differential equation. Our main result shows that for any $n,m geq 1$ there are differential equations $ddot{x}+f(x,dot{x})dot{x}+ g(x)=0$, with f and g polynomials of ...
Sabrina Badi, Amar Makhlouf
doaj
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Maximum number of limit cycles for generalized Li'enard differential equations
Electronic Journal of Differential Equations, 2013 Applying the averaging theory of first and second order to a class of generalized polynomial Lienard differential equations, we improve the known lower bounds for the maximum number of limit cycles that this class can exhibit.
Sabrina Badi, Amar Makhlouf
doaj
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Distribution theory of the least squares averaging estimator [PDF]
Journal of Econometrics, 2013 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire +2 more sources
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Stochastic bifurcation analysis in Brusselator system with white noise
Advances in Difference Equations, 2019 In this paper, we mainly study the stochastic stability and stochastic bifurcation of Brusselator system with multiplicative white noise. Firstly, by a polar coordinate transformation and a stochastic averaging method, the original system is transformed ...
Changzhao Li, Juan Zhang
doaj +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani +6 more
wiley +1 more source