Results 61 to 70 of about 3,441 (241)

Acquiring Resistance Against a Retroviral Infection via CRISPR/Cas9 Targeted Genome Editing in a Commercial Chicken Line [PDF]

, 2020
Genome editing technology provides new possibilities for animal breeding and aid in understanding host-pathogen interactions. In poultry, retroviruses display one of the most difficult pathogens to control by conventional strategies such as vaccinations.
Bartsch, Denise, Bertzbach, Luca D., Flisikowski, Krzysztof, Hellmich, Romina, Kaufer, Benedikt B., Lengyel, Kamila, Nair, Venugopal, Preisinger, Rudolf, Schlickenrieder, Antonina, Schusser, Benjamin, Sid, Hicham, Thoma, Theresa   +11 more
core   +1 more source

Role of Virus-Encoded microRNAs in Avian Viral Diseases [PDF]

, 2019
To survive in the host cells, viruses have to adapt various strategies, which include the modulation of microRNA (miRNA) pathway through virus-encoded miRNAs to modulate the host cellular environment.
Nair, Venugopal, Yao, Yongxiu
core   +2 more sources

Isolation and analysis of a very virulent Marek’s disease virus strain in China [PDF]

, 2013
BACKGROUND: A severe MD was broken out at a farm in Shandong, China, despite FC126 vaccination of the chickens at 1-day-old. The mortality of the flocks reached up to 38.3%.
Hongchao Ma, Hu Shan, Jianlin Wang, Lijuan Zhang, Linlin Chen, Zhenhua Gong, Zhiliang Wang   +6 more
core   +1 more source

MicroRNA-23b Promotes Avian Leukosis Virus Subgroup J (ALV-J) Replication by Targeting IRF1 [PDF]

Scientific Reports, 2015
AbstractAvian leukosis virus subgroup J (ALV-J) can cause several different leukemia-like proliferative diseases in the hemopoietic system of chickens. Here, we investigated the transcriptome profiles and miRNA expression profiles of ALV-J-infected and uninfected chicken spleens to identify the genes and miRNAs related to ALV-J invasion.
Zhenhui Li, Biao Chen, Min Feng, Hongjia Ouyang, Ming Zheng, Qiao Ye, Qinghua Nie, Xiquan Zhang   +7 more
openaire   +2 more sources

The hr1 and Fusion Peptide Regions of the Subgroup B Avian Sarcoma and Leukosis Virus Envelope Glycoprotein Influence Low pH-Dependent Membrane Fusion [PDF]

, 2007
The avian sarcoma and leukosis virus (ASLV) envelope glycoprotein (Env) is activated to trigger fusion by a two-step mechanism involving receptor-priming and low pH fusion activation.
AJ Dorner, AL Boerger, Angeline Rose Babel, CA Bova, CA Bova, D Elleder, DA Steinhauer, DC Melder, GB Melikyan, GB Melikyan, GJ Rainey, HB Adkins, HB Adkins, HB Adkins, J Brojatsch, JA Young, James Bruce, John A.T. Young, JW Balliet, JW Bruce, L Rong, LD Hernandez, Linqi Zhang, LJ Earp, LJ Earp, M Himly, N Chai, P Bates, R Damico, RA Katz, RA Taplitz, RC Netter, RJ Barnard, RL Damico, RM Markosyan, RS Daniels, S Matsuyama, SE Delos, SE Delos, SE Delos, SL Holmen, SL Holmen, W Mothes   +42 more
core   +6 more sources

Keratin 6a marks mammary bipotential progenitor cells that can give rise to a unique tumor model resembling human normal-like breast cancer. [PDF]

, 2011
Progenitor cells are considered an important cell of origin of human malignancies. However, there has not been any single gene that can define mammary bipotential progenitor cells, and as such it has not been possible to use genetic methods to introduce ...
Bu, W, Chamness, GC, Chen, J, Creighton, CJ, Hilsenbeck, SG, Huang, J, Huang, S, Leavitt, AD, Li, Y, Morrison, GD, Roop, DR   +10 more
core   +2 more sources

Alpharetroviral Vectors: From a Cancer-Causing Agent to a Useful Tool for Human Gene Therapy [PDF]

, 2014
Gene therapy using integrating retroviral vectors has proven its effectiveness in several clinical trials for the treatment of inherited diseases and cancer.
Labenski, Verena, Schambach, Axel, Suerth, Julia D.   +2 more
core   +2 more sources

Inhibitors of SARS-CoV entry--identification using an internally-controlled dual envelope pseudovirion assay. [PDF]

, 2011
Severe acute respiratory syndrome-associated coronavirus (SARS-CoV) emerged as the causal agent of an endemic atypical pneumonia, infecting thousands of people worldwide.
Agudelo, Juliet, Amberg, Sean M, Chen, Yen Ting, Craik, Charles S, Goetz, David H, Hansell, Elizabeth, Lu, Kai, McKerrow, James, Roush, William R, Simmons, Graham, Zhou, Yanchen   +10 more
core   +1 more source

Role of Virus-Encoded microRNAs in Avian Viral Diseases

Viruses, 2014
With total dependence on the host cell, several viruses have adopted strategies to modulate the host cellular environment, including the modulation of microRNA (miRNA) pathway through virus-encoded miRNAs.
Yongxiu Yao, Venugopal Nair
doaj   +1 more source

ACSL1 Inhibits ALV-J Replication by IFN-Ⅰ Signaling and PI3K/Akt Pathway

Frontiers in Immunology, 2021
J subgroup avian leukosis virus (ALV-J) infection causes serious immunosuppression problems, leading to hematopoietic malignancy tumors in chicken.
Qihong Zhang, Qihong Zhang, Qihong Zhang, Tingting Xie, Tingting Xie, Tingting Xie, Guodong Mo, Guodong Mo, Guodong Mo, Zihao Zhang, Zihao Zhang, Zihao Zhang, Ling Lin, Ling Lin, Ling Lin, Xiquan Zhang, Xiquan Zhang, Xiquan Zhang   +17 more
doaj   +1 more source