Results 101 to 110 of about 1,034,274 (259)

A role for neutrophils in early enthesitis in spondyloarthritis

Arthritis Research & Therapy, 2022
Background Neutrophils are present in the early phases of spondyloarthritis-related uveitis, skin and intestinal disease, but their role in enthesitis, a cardinal musculoskeletal lesion in spondyloarthritis, remains unknown.
Zheni Stavre, Charles Bridgewood, Qiao Zhou, Yukiko Maeda, Ting-ting Huang, Jozsef Karman, Almas Khan, Sami Giryes, Kassem Sharif, Dennis McGonagle, Ellen M. Gravallese   +10 more
doaj   +1 more source

Deucravacitinib in Active Psoriatic Arthritis: Efficacy and Safety up to 52 Weeks From the Randomized, Double‐Blind, Phase 3 POETYK PsA‐2 Trial

Arthritis &Rheumatology, Accepted Article.
Objective To assess the efficacy and safety of deucravacitinib, an oral, selective tyrosine kinase 2 inhibitor, in patients with psoriatic arthritis (PsA) who were naive to biologic disease‐modifying antirheumatic drugs or received tumor necrosis factor inhibitors. Methods In the 52‐week (W), double‐blind, placebo‐controlled, phase 3 POETYK PsA‐2 study
Philip J. Mease, Vinod Chandran, April W. Armstrong, Ricardo Blanco, Alexis Ogdie, Evan L. Siegel, Alice B. Gottlieb, Xiaofeng Zeng, Diamant Thaçi, Mitsumasa Kishimoto, Hendrik Schulze‐Koops, Alan Kivitz, Eva Dokoupilová, Akimichi Morita, Eric M. Ruderman, Michael Plewinski, Kejia Wang, Caroline Sardinas, Eleni Vritzali, John Vaile, Atul Deodhar   +20 more
wiley   +1 more source

Novel Therapeutic Targets in Axial Spondyloarthritis [PDF]

, 2018
Purpose of review Axial spondyloarthritis remains an area of significant unmet clinical need with only two immune pathways currently targeted by licenced therapies compared to other immune-mediated inflammatory joint disorders such as rheumatoid ...
Bowness, Paul, Worth, C, M. Hussein Al-Mossawi, Al-Mossawi, Mohammad, Claudia Worth, Bowness, P, Paul Bowness, Al-Mossawi, MH   +7 more
core   +1 more source

Long non-coding RNA (H19) in patients with spondyloarthritis: association with disease parameters and ultrasonographic findings

Egyptian Rheumatology and Rehabilitation
Background Spondyloarthritis is a well-known chronic inflammatory disorder; despite recent advances, its genetic basis remains poorly understood. Recently, long non-coding RNA (H19) was identified to be associated with various human cancers and studied ...
A. I. EL-Zwawy, Eiman Soliman, Eman T. Elsayed, Mai M. Morsy   +3 more
doaj   +1 more source

Recommendations for the treatment of axial spondyloarthritis: An analysis of the updated ASAS/EULAR 2022 clinical guidelines

Научно-практическая ревматология
The article discusses the 2022 updated version of the collaborative ASAS/EULAR (Assessment in SpondyloArthritis international Society/European Alliance of Associations for Rheumatology) recommendations for the treatment of axial spondyloarthritis.
Sh. F. Erdes, T. V. Dubinina
doaj   +1 more source

Bone Disease in Axial Spondyloarthritis [PDF]

Calcified Tissue International, 2017
Axial spondyloarthritis is a chronic inflammatory skeletal disorder with an important burden of disease, affecting the spine and sacroiliac joints and typically presenting in young adults. Ankylosing spondylitis, diagnosed by the presence of structural changes to the skeleton, is the prototype of this disease group.
Van Mechelen, Margot, Gulino, Giulia Rossana, de Vlam, Kurt, Lories, Rik   +3 more
openaire   +3 more sources

Risk of Cancer According to Duration of Targeted Therapy Exposure in Spondyloarthritis: A Nationwide Cohort Study From the French Health Insurance Database

Arthritis &Rheumatology, EarlyView.
Objective To assess the association between duration of targeted therapy exposure and cancer risk in patients with spondyloarthritis (SpA), including those with psoriatic arthritis, axial SpA, and other subtypes. Methods This nationwide cohort study used the French health insurance database to identify adults with SpA initiating a targeted therapy ...
Karine Tankovic, Pascal Claudepierre, Tat Thang Vo, Tran Trong Khoi Le, Siham Iggui, Laetitia Penso, Emilie Sbidian, Laura Pina Vegas   +7 more
wiley   +1 more source

The genetics of ankylosing spondylitis and axial spondyloarthritis

, 2012
Ankylosing spondylitis (AS) and spondyloarthritis are strongly genetically determined. The long-standing association with HLA-B27 is well described, although the mechanism by which that association induces AS remains uncertain.
Robinson, P. C., Brown, Matthew A., Robinson, Philip C., Brown, Matthew A   +3 more
core   +1 more source

Expert Perspective: Toward Treat‐to‐Target Management in Adult Idiopathic Inflammatory Myopathies

Arthritis &Rheumatology, Accepted Article.
Treat‐to‐target (T2T) has transformed the management of several rheumatic diseases through predefined therapeutic goals, structured disease assessment, and timely treatment adjustment. Despite major advances in the understanding and treatment of idiopathic inflammatory myopathies (IIM), a formal T2T framework for adult IIM has not yet been established.
Shiri Keret, Nantakarn Pongtarakulpanit, Rohit Aggarwal   +2 more
wiley   +1 more source

Features of Axial Spondyloarthritis in Two Multicenter Cohorts of Patients with Psoriasis, Uveitis, and Colitis Presenting with Undiagnosed Back Pain

Arthritis & Rheumatology
We aimed to assess the following: (1) the frequency of axial spondyloarthritis (axSpA) according to extra‐articular presentation and HLA‐B27 status, (2) clinical and imaging features that distinguish axSpA from non‐axSpA, and (3) the impact of magnetic ...
W. Maksymowych, R. Carmona, Ulrich Weber, S. Aydin, J. Yeung, Jodie Reis, A. Masetto, S. Rohekar, D. Mosher, Olga Zouzina, L. Martin, Stephanie Keeling, J. Paschke, R. Dadashova, A. Carapellucci, S. Wichuk, Robert G. W. Lambert, Jon Chan   +17 more
semanticscholar   +1 more source