Results 11 to 20 of about 3,132 (177)
Multi-species atlas resolves an axolotl limb development and regeneration paradox
Nature Communications, 2023 Humans and other tetrapods are considered to require apical-ectodermal-ridge (AER) cells for limb development, and AER-like cells are suggested to be re-formed to initiate limb regeneration.
Jixing Zhong +6 more
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The specialist in regeneration—the Axolotl—a suitable model to study bone healing?
npj Regenerative Medicine, 2022 While the axolotl’s ability to completely regenerate amputated limbs is well known and studied, the mechanism of axolotl bone fracture healing remains poorly understood. One reason might be the lack of a standardized fracture fixation in axolotl.
A. Polikarpova +7 more
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Frontiers in Endocrinology, 2022 The Melanocortin-3 receptor (MC3R) and Melanocortin-4 receptor (MC4R), two members of the key hypothalamic neuropeptide signaling, function as complex mediators to control the central appetitive and energy homeostasis.
Xiaozhu Wang +15 more
doaj +1 more source
Scientific Reports, 2022 Few experimental model systems are available for the rare congenital heart diseases of double inlet left ventricle (DILV), a subgroup of univentricular hearts, and excessive trabeculation (ET), or noncompaction.
Sophie Meyer +8 more
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BioScience, 2015 AbstractThe Mexican axolotl (Ambystoma mexicanum) is an icon of culture, a revered aquarium pet, and a highly valued animal model in biomedical research. Unfortunately, Mexican axolotls are critically endangered in their natural Xochimilco habitat in Mexico City.
S Randal, Voss +2 more
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Comparative RNA-seq analysis in the unsequenced axolotl: the oncogene burst highlights early gene expression in the blastema. [PDF]
PLoS Computational Biology, 2013 The salamander has the remarkable ability to regenerate its limb after amputation. Cells at the site of amputation form a blastema and then proliferate and differentiate to regrow the limb.
Ron Stewart +16 more
doaj +1 more source
A scATAC-seq atlas of chromatin accessibility in axolotl brain regions
Scientific Data, 2023 Axolotl (Ambystoma mexicanum) is an excellent model for investigating regeneration, the interaction between regenerative and developmental processes, comparative genomics, and evolution.
Weimin Feng +19 more
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Rediscovering the Axolotl as a Model for Thyroid Hormone Dependent Development
Frontiers in Endocrinology, 2019 The Mexican axolotl (Ambystoma mexicanum) is an important model organism in biomedical research. Much current attention is focused on the axolotl's amazing ability to regenerate tissues and whole organs after injury. However, not forgotten is the axolotl'
Anne Crowner +3 more
doaj +1 more source
The use of transgenics in the laboratory axolotl [PDF]
Developmental Dynamics, 2021 AbstractThe ability to generate transgenic animals sparked a wave of research committed to implementing such technology in a wide variety of model organisms. Building a solid base of ubiquitous and tissue‐specific reporter lines has set the stage for later interrogations of individual cells or genetic elements.
Lydia Tilley +4 more
openaire +2 more sources