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The sound of an axon's growth [PDF]

open access: yesPhys. Rev. E 99, 050401 (2019), 2018
Axons are linear processes of nerve cells that can range from a few tens of micrometers up to meters in length. In addition to external cues, the length of an axon is also regulated by unknown internal mechanisms. Molecular motors have been suggested to generate oscillations with an axon length-dependent frequency that could be used to measure an axon ...
Folz, Frederic   +3 more
arxiv   +8 more sources

Modeling of interstitial branching of axonal networks [PDF]

open access: yes1. J. Integr. Neurosci. 12, 1-14, (2013), 2013
A single axon can generate branches connecting with plenty synaptic targets. Process of branching is very important for making connections in central nervous system. The interstitial branching along primary axon shaft occurs during nervous system development. Growing axon makes pause in its movement and leaves active points behind its terminal. The new
Gafarov, F.   +2 more
arxiv   +5 more sources

Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo

open access: greenJournal of Physiology, 1952
In the preceding paper (Hodgkin, Huxley & Katz, 1952) we gave a general description of the time course of the current which flows through the membrane of the squid giant axon when the potential difference across the membrane is suddenly changed from its ...
A. Hodgkin, A. Huxley
semanticscholar   +2 more sources

A model of fasciculation and sorting in mixed populations of axons [PDF]

open access: yesPhys. Rev. E 84, 021908 (2011), 2010
We extend a recently proposed model (Chaudhuri et al., EPL 87, 20003 (2009)) aiming to describe the formation of fascicles of axons during neural development. The growing axons are represented as paths of interacting directed random walkers in two spatial dimensions.
D. ben Avraham   +11 more
arxiv   +3 more sources

Node of Ranvier length as a potential regulator of myelinated axon conduction speed

open access: yeseLife, 2017
Myelination speeds conduction of the nerve impulse, enhancing cognitive power. Changes of white matter structure contribute to learning, and are often assumed to reflect an altered number of myelin wraps. We now show that, in rat optic nerve and cerebral
I Lorena Arancibia-Cárcamo   +5 more
doaj   +2 more sources

In vivo measurement of afferent activity with axon-specific calcium imaging. [PDF]

open access: yesNature Neuroscience, 2018
In vivo calcium imaging from axons provides direct interrogation of afferent neural activity, informing the neural representations that a local circuit receives.
Broussard, Gerard Joey   +8 more
core   +2 more sources

Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy

open access: yesFrontiers in Aging Neuroscience, 2022
IntroductionThe typical symptoms of Alzheimer’s disease (AD) are cognitive impairment, disrupted spatial orientation, behavioral and psychiatric abnormalities, and later motor deficits. Neuropathologically, AD is characterized by deposits of pathological
Veronika Mate   +20 more
doaj   +1 more source

Estimation of electric field impact in deep brain stimulation from axon diameter distribution in the human brain [PDF]

open access: yesBiomedical Physics & Engineering Express 2021, 2021
Background: Finite element method (FEM) simulations of the electric field magnitude (EF) are commonly used to estimate the affected tissue surrounding the active contact of deep brain stimulation (DBS) leads. Previous studies have found that DBS starts to noticeably activate axons at approximately 0.2 V/mm, corresponding to activation of 3.4 $\mu$m ...
arxiv   +1 more source

Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation

open access: yesActa Neuropathologica Communications, 2020
Immunotherapies targeting pathological tau have recently emerged as a promising approach for treatment of neurodegenerative disorders. We have previously showed that the mouse antibody DC8E8 discriminates between healthy and pathological tau, reduces tau
Monika Zilkova   +14 more
doaj   +1 more source

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