Results 1 to 10 of about 304,829 (369)

Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy

Frontiers in Aging Neuroscience, 2022
IntroductionThe typical symptoms of Alzheimer’s disease (AD) are cognitive impairment, disrupted spatial orientation, behavioral and psychiatric abnormalities, and later motor deficits. Neuropathologically, AD is characterized by deposits of pathological
Veronika Mate, Veronika Mate, Tomas Smolek, Tomas Smolek, Tomas Smolek, Zuzana Vince Kazmerova, Zuzana Vince Kazmerova, Santosh Jadhav, Santosh Jadhav, Veronika Brezovakova, Bernadeta Jurkanin, Ivana Uhrinova, Ivana Uhrinova, Neha Basheer, Norbert Zilka, Norbert Zilka, Stanislav Katina, Stanislav Katina, Stanislav Katina, Petr Novak, Petr Novak   +20 more
doaj   +1 more source

Estimation of electric field impact in deep brain stimulation from axon diameter distribution in the human brain [PDF]

Biomedical Physics & Engineering Express 2021, 2021
Background: Finite element method (FEM) simulations of the electric field magnitude (EF) are commonly used to estimate the affected tissue surrounding the active contact of deep brain stimulation (DBS) leads. Previous studies have found that DBS starts to noticeably activate axons at approximately 0.2 V/mm, corresponding to activation of 3.4 $\mu$m ...
arxiv   +1 more source

Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation

Acta Neuropathologica Communications, 2020
Immunotherapies targeting pathological tau have recently emerged as a promising approach for treatment of neurodegenerative disorders. We have previously showed that the mouse antibody DC8E8 discriminates between healthy and pathological tau, reduces tau
Monika Zilkova, Anna Nolle, Branislav Kovacech, Eva Kontsekova, Petronela Weisova, Peter Filipcik, Rostislav Skrabana, Michal Prcina, Tomas Hromadka, Ondrej Cehlar, Gabriela Paulikova Rolkova, Denisa Maderova, Michal Novak, Norbert Zilka, Jeroen J. M. Hoozemans   +14 more
doaj   +1 more source

Monitoring system for electrical variables implementing blockchain and python

Tecnura, 2022
Objective: This article presents one of the Blockchain applications in power systems employing the electrical variables monitoring delivered by a simulated relay.
Diego Armando Giral Ramírez, Javier Andres Muñoz Romero, Carlos Alberto Ramírez Vanegas   +2 more
doaj   +1 more source

Truncated tau deregulates synaptic markers in rat model for human tauopathy

Frontiers in Cellular Neuroscience, 2015
Synaptic failure and neurofibrillary degeneration are two major neuropathological substrates of cognitive dysfunction in Alzheimer’s disease (AD). Only a few studies have demonstrated a direct relationship between these two AD hallmarks.
Santosh eJadhav, Stanislav eKatina, Andrej eKovac, Andrej eKovac, Zuzana eKazmerova, Zuzana eKazmerova, Michal eNovak, Michal eNovak, Norbert eZilka, Norbert eZilka   +9 more
doaj   +1 more source

Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans

Acta Neuropathologica Communications, 2019
Pathologically altered tau protein is a common denominator of neurodegenerative disorders including Alzheimer’s disease (AD) and other tauopathies.
Petronela Weisová, Ondrej Cehlár, Rostislav Škrabana, Monika Žilková, Peter Filipčík, Branislav Kováčech, Michal Prčina, Ľubica Wojčiaková, Ľubica Fialová, Tomáš Smolek, Eva Kontseková, Norbert Žilka, Michal Novák   +12 more
doaj   +1 more source

Student Pharmacists’ Perspectives Regarding a Virtually Delivered Research Proposal Course in the Doctor of Pharmacy Curriculum

Pharmacy, 2023
This study aimed to assess third-year student pharmacists’ perspectives regarding a virtually delivered research proposal course. A 23-item questionnaire was distributed to third-year student pharmacists enrolled in a research proposal course over three ...
David R. Axon
doaj   +1 more source

FUNDAMANT: an interventional 72-week phase 1 follow-up study of AADvac1, an active immunotherapy against tau protein pathology in Alzheimer’s disease

Alzheimer’s Research & Therapy, 2018
Background Neurofibrillary pathology composed of tau protein is closely correlated with severity and phenotype of cognitive impairment in patients with Alzheimer’s disease and non-Alzheimer’s tauopathies.
Petr Novak, Reinhold Schmidt, Eva Kontsekova, Branislav Kovacech, Tomas Smolek, Stanislav Katina, Lubica Fialova, Michal Prcina, Vojtech Parrak, Peter Dal-Bianco, Martin Brunner, Wolfgang Staffen, Michael Rainer, Matej Ondrus, Stefan Ropele, Miroslav Smisek, Roman Sivak, Norbert Zilka, Bengt Winblad, Michal Novak   +19 more
doaj   +1 more source

Estimating axon radius using diffusion-relaxation MRI: calibrating a surface-based relaxation model with histology [PDF]

Frontiers in Neuroscience, Vol 17, 2023. https://www.frontiersin.org/articles/10.3389/fnins.2023.1209521, 2023
Axon radius is a potential biomarker for brain diseases and a crucial tissue microstructure parameter that determines the speed of action potentials. Diffusion MRI (dMRI) allows non-invasive estimation of axon radius, but accurately estimating the radius of axons in the human brain is challenging.
arxiv   +1 more source

Development and Implementation of a Healthcare Database Analysis Course for Graduate Students

Pharmacy, 2022
There emerged a need to develop and implement a new healthcare database analysis course for Health Economics and Outcomes Research (HEOR) graduate students, which would allow students to apply their biostatistics and study design skills to answer ...
David R. Axon
doaj   +1 more source