Results 1 to 10 of about 434,135 (356)

Enriched environment ameliorates propagation of tau pathology and improves cognition in rat model of tauopathy

Frontiers in Aging Neuroscience, 2022
IntroductionThe typical symptoms of Alzheimer’s disease (AD) are cognitive impairment, disrupted spatial orientation, behavioral and psychiatric abnormalities, and later motor deficits. Neuropathologically, AD is characterized by deposits of pathological
Veronika Mate, Veronika Mate, Tomas Smolek, Tomas Smolek, Tomas Smolek, Zuzana Vince Kazmerova, Zuzana Vince Kazmerova, Santosh Jadhav, Santosh Jadhav, Veronika Brezovakova, Bernadeta Jurkanin, Ivana Uhrinova, Ivana Uhrinova, Neha Basheer, Norbert Zilka, Norbert Zilka, Stanislav Katina, Stanislav Katina, Stanislav Katina, Petr Novak, Petr Novak   +20 more
doaj   +1 more source

Humanized tau antibodies promote tau uptake by human microglia without any increase of inflammation

Acta Neuropathologica Communications, 2020
Immunotherapies targeting pathological tau have recently emerged as a promising approach for treatment of neurodegenerative disorders. We have previously showed that the mouse antibody DC8E8 discriminates between healthy and pathological tau, reduces tau
Monika Zilkova, Anna Nolle, Branislav Kovacech, Eva Kontsekova, Petronela Weisova, Peter Filipcik, Rostislav Skrabana, Michal Prcina, Tomas Hromadka, Ondrej Cehlar, Gabriela Paulikova Rolkova, Denisa Maderova, Michal Novak, Norbert Zilka, Jeroen J. M. Hoozemans   +14 more
doaj   +1 more source

Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern

EBioMedicine, 2022
Summary: Background: The emergence of new SARS-CoV-2 variants of concern B.1.1.7 (Alpha), B.1.351 (Beta), P.1 (Gamma) and B.1.617.2 (Delta) that harbor mutations in the viral S protein raised concern about activity of current vaccines and therapeutic ...
Branislav Kovacech, Lubica Fialova, Peter Filipcik, Rostislav Skrabana, Monika Zilkova, Natalia Paulenka-Ivanovova, Andrej Kovac, Denisa Palova, Gabriela Paulikova Rolkova, Katarina Tomkova, Natalia Turic Csokova, Karina Markova, Michaela Skrabanova, Kristina Sinska, Neha Basheer, Petra Majerova, Jozef Hanes, Vojtech Parrak, Michal Prcina, Ondrej Cehlar, Martin Cente, Juraj Piestansky, Michal Fresser, Michal Novak, Monika Slavikova, Kristina Borsova, Viktoria Cabanova, Bronislava Brejova, Tomas Vinař, Jozef Nosek, Boris Klempa, Ludek Eyer, Vaclav Hönig, Martin Palus, Daniel Ruzek, Tereza Vyhlidalova, Petra Strakova, Blanka Mrazkova, Dagmar Zudova, Gizela Koubkova, Vendula Novosadova, Jan Prochazka, Radislav Sedlacek, Norbert Zilka, Eva Kontsekova   +44 more
doaj   +1 more source

Development of the early axon scaffold in the rostral brain of the small spotted cat shark (Scyliorhinus canicula) embryo [PDF]

, 2014
International audienceThe cat shark is increasingly used as a model for Chondrichthyes, an evolutionarily important sister group of the bony vertebrates that include teleosts and tetrapods.
Schubert, Frank, Ware, Michelle, Waring, Colin   +2 more
core   +8 more sources

Monitoring system for electrical variables implementing blockchain and python

Tecnura, 2022
Objective: This article presents one of the Blockchain applications in power systems employing the electrical variables monitoring delivered by a simulated relay.
Diego Armando Giral Ramírez, Javier Andres Muñoz Romero, Carlos Alberto Ramírez Vanegas   +2 more
doaj   +1 more source

Truncated tau deregulates synaptic markers in rat model for human tauopathy

Frontiers in Cellular Neuroscience, 2015
Synaptic failure and neurofibrillary degeneration are two major neuropathological substrates of cognitive dysfunction in Alzheimer’s disease (AD). Only a few studies have demonstrated a direct relationship between these two AD hallmarks.
Santosh eJadhav, Stanislav eKatina, Andrej eKovac, Andrej eKovac, Zuzana eKazmerova, Zuzana eKazmerova, Michal eNovak, Michal eNovak, Norbert eZilka, Norbert eZilka   +9 more
doaj   +1 more source

Regulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegans. [PDF]

, 2016
The capacity of an axon to regenerate is regulated by its external environment and by cell-intrinsic factors. Studies in a variety of organisms suggest that alterations in axonal microtubule (MT) dynamics have potent effects on axon regeneration.
CHISHOLM, Andrew, Tang, Ngang
core   +2 more sources

Therapeutic antibody targeting microtubule-binding domain prevents neuronal internalization of extracellular tau via masking neuron surface proteoglycans

Acta Neuropathologica Communications, 2019
Pathologically altered tau protein is a common denominator of neurodegenerative disorders including Alzheimer’s disease (AD) and other tauopathies.
Petronela Weisová, Ondrej Cehlár, Rostislav Škrabana, Monika Žilková, Peter Filipčík, Branislav Kováčech, Michal Prčina, Ľubica Wojčiaková, Ľubica Fialová, Tomáš Smolek, Eva Kontseková, Norbert Žilka, Michal Novák   +12 more
doaj   +1 more source

Akt1-Inhibitor of DNA binding2 is essential for growth cone formation and axon growth and promotes central nervous system axon regeneration. [PDF]

, 2016
Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone ...
Ahn, Jee-Yin, Brennan-Minnella, Angela M, Cho, Sung-Woo, Hwang, Inwoo, Jin, Eun-Ju, Ko, Hyo Rim, Kwon, Il-Sun, Lee, Kyung-Hoon, Shin, Joo-Ho, Swanson, Raymond   +9 more
core   +2 more sources

Modeling of interstitial branching of axonal networks [PDF]

, 2013
A single axon can generate branches connecting with plenty synaptic targets. Process of branching is very important for making connections in central nervous system.
Gafarov, F., Khusnutdinov, N., Suleymanov, Y.   +2 more
core   +2 more sources