Results 211 to 220 of about 117,469 (259)
Investigating the Cytoskeleton of DRGs Using Cryo‐Electron Microscopy and Deep Learning
Cytoskeleton, EarlyView.ABSTRACT We describe a method for determining the ultrastructural organization of axons and varicosities of cultured dorsal root ganglion (DRG) neurons using cryogenic electron microscopy (cryo‐EM). Cryo‐EM reveals the dimensions, proximity, and overall organization of biological specimens in a near‐native state, avoiding artifacts of fixation and ...
M. Neal Waxham +3 more
wiley +1 more source
Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays
Cytoskeleton, EarlyView.ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz +2 more
wiley +1 more source
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2012
The growth and guidance of axons is an undertaking of both great complexity and great precision, involving processes at a range of length and time scales. Correct axonal guidance involves directing the tips of individual axons and their branches, interactions between branches of a single axon, and interactions between axons of different neurons.
Mortimer, Duncan +2 more
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The growth and guidance of axons is an undertaking of both great complexity and great precision, involving processes at a range of length and time scales. Correct axonal guidance involves directing the tips of individual axons and their branches, interactions between branches of a single axon, and interactions between axons of different neurons.
Mortimer, Duncan +2 more
openaire +3 more sources
Neurotrophic factors and axonal growth
Current Opinion in Neurobiology, 2002Neuronal morphological differentiation is regulated by numerous polypeptide growth factors (neurotrophic factors). Recently, significant progress has been achieved in clarifying the roles of neurotrophins as well as glial cell line-derived neurotrophic factor family members in peripheral axon elongation during development.
Annette, Markus +2 more
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Microtubules and axonal growth
Current Opinion in Cell Biology, 1997Twenty years of controversy have not produced a consensus concerning the mechanisms by which the microtubule array of the growing neuronal axon is established. At the heart of the controversy is the issue of whether tubulin is actively transported down the axon as assembled microtubules or as free subunits.
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Molecular Mechanisms of Axonal Growth
2008Outgrowth of axons during neuronal development, as well as their regeneration after injury, of the adult nervous system is controlled by specific extracellular cues which are diffusible, or bound to cell membranes or extracellular matrix. The exact molecular mechanisms through which these extracellular signals are integrated by the growing axon, are ...
Bouquet, C., Nothias, F.
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Role of Laminin for Axonal Growth
1994The basement membrane glycoprotein laminin has been shown in vitro to stimulate the growth or regeneration of neuronal processes [2], to act together with neurotrophic factors to promote neuronal survival [8] and to stimulate the proliferation of glial cells [23].
D, Edgar +3 more
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Axonal growth in evolutionary neurogenesis
Artificial Life and Robotics, 2001Creating ways for neural networks to evolve is an important goal in the field of artificial evolution. The main problem is how to encode the structure and properties of the neural network in the genome. If one overloads the genome with detailed network information, the evolutionary time increases prohibitively.
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Nature Reviews Neuroscience, 2019
RHOA drives the formation of actin arcs in neuronal growth cones in mice, limiting microtubule protrusion and restricting axon growth.
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RHOA drives the formation of actin arcs in neuronal growth cones in mice, limiting microtubule protrusion and restricting axon growth.
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Axonal Growth-Associated Proteins
Annual Review of Neuroscience, 1989Elongation ofaxons and active remodeling of their terminal arbors under lies the assembly of neural circuits during development, determines the success or fai lure of nerve regeneration, and may contribute to some forms of synaptic plast icity in adult brains.
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