Results 291 to 300 of about 6,133,766 (357)

Ubiquitin C‐Terminal Hydrolase L1 (UCHL1), Beyond Hydrolysis

BioEssays, EarlyView.
UCHL1 is a neuron‐enriched component of the ubiquitin‐proteasome system. This review debates the biological relevance of its biochemical roles: limited DUB activity, potential ligase function, and mono‐ubiquitin stabilization. We emphasize the need to clarify the mechanisms and identify natural substrates for each function to understand their role in ...
Anwar Bdarneh, Inbal Maniv, Michael H. Glickman   +2 more
wiley   +1 more source

Chitosan/PLGA-based tissue engineered nerve grafts with SKP-SC-EVs enhance sciatic nerve regeneration in dogs through miR-30b-5p-mediated regulation of axon growth. [PDF]

Bioact Mater
Yu M, Shen M, Chen D, Li Y, Zhou Q, Deng C, Zhou X, Zhang Q, He Q, Wang H, Cong M, Shi H, Gu X, Zhou S, Ding F.   +14 more
europepmc   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Rewiring the future: drugs abused in adolescence may predispose to mental illness in adult life by altering dopamine axon growth. [PDF]

J Neural Transm (Vienna)
Avramescu RG, Hernandez G, Flores C.
europepmc   +1 more source

Regulation of axon growth by the JIP1–AKT axis

Journal of Cell Science, 2014
F. Dajas-Bailador, I. Bantounas, E. V. Jones, A. Whitmarsh   +3 more
semanticscholar   +1 more source

Artificial intelligence‐assisted design, synthesis and analysis of smart biomaterials

BMEMat, EarlyView.
Smart biomaterials are rapidly emerging as tools for tissue engineering, and artificial intelligence has played essential roles in biomaterial studies. By bridging the literature gap in AI‐based design, synthesis and analysis of smart biomaterials, the current review shares perspectives on how biomaterial scientists can practically incorporate AI for ...
Pengfei Jiang, Yefei Dai, Yujun Hou, Joshua Stein, Shichen Steven Lin, Chaochen Zhou, Yannan Hou, Rongrong Zhu, Ki‐Bum Lee, Letao Yang   +9 more
wiley   +1 more source

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

BMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu, Chung Yin Matthew Cheung, Liling Liu, Hoi Pan Harry Cheung, Kam Yu Tam, Dai Fei Elmer Ker, Sarah H. Cartmell, Chuanbin Mao, Zhiyong Zhang, Dan Michelle Wang   +9 more
wiley   +1 more source

Activation of epidermal growth factor receptors directs astrocytes to organize in a network surrounding axons in the developing rat optic nerve

, 2004
Bin Liu, Arthur H. Neufeld
openalex   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Eugenia brasiliensis: Analysis of the Chemical Profile and Evaluation of Cytotoxic Potential

Chemistry &Biodiversity, EarlyView.
Leaves of Eugenia brasiliensis were dried, crushed and macerated with polarity increment. The antiporliferative and anti‐migratory potential and the cell cycle were evaluated. 28 compounds were tentatively identified by mass sceptrometry. ABSTRACT This work evaluated the antiproliferative potential of Eugenia brasiliensis leaf extracts against the HeLa
Giovana G. F. V. de Oliveira, Milena F. Longue, Letícia M. R. Pescinelli, Thiago S. Charret, Thalya S. R. Nogueira, Mariana T. M. Pereira, Ivo J. C. Vieira, Lucas S. Abreu, Vinicius D. B. Pascoal, Aislan C. R. F. Pascoal   +9 more
wiley   +1 more source