Results 301 to 310 of about 6,316,330 (345)

Oligodendrocytes repel axons and cause axonal growth cone collapse

Journal of Cell Science, 1989
ABSTRACT We have examined the interactions between axons regenerating from dorsal root ganglia (DRGs) derived from newborn rats and oligodendrocytes cultured by three different techniques. Cultures examined after 2 days have a profuse outgrowth of axons from the DRGs, forming a dense mat on the culture surface.
J W, Fawcett, J, Rokos, I, Bakst
openaire   +2 more sources

Microtubules and axonal growth

Current Opinion in Cell Biology, 1997
Twenty years of controversy have not produced a consensus concerning the mechanisms by which the microtubule array of the growing neuronal axon is established. At the heart of the controversy is the issue of whether tubulin is actively transported down the axon as assembled microtubules or as free subunits.
openaire   +2 more sources

Molecular Mechanisms of Axonal Growth

2008
Outgrowth of axons during neuronal development, as well as their regeneration after injury, of the adult nervous system is controlled by specific extracellular cues which are diffusible, or bound to cell membranes or extracellular matrix. The exact molecular mechanisms through which these extracellular signals are integrated by the growing axon, are ...
Bouquet, C., Nothias, F.
openaire   +3 more sources

Axonal Growth and Targeting

2012
The growth and guidance of axons is an undertaking of both great complexity and great precision, involving processes at a range of length and time scales. Correct axonal guidance involves directing the tips of individual axons and their branches, interactions between branches of a single axon, and interactions between axons of different neurons.
Mortimer, Duncan, Simpson, Hugh D., Goodhill, Geoffrey J.   +2 more
openaire   +2 more sources

Axonal growth and guidance

Trends in Neurosciences, 1983
Abstract The motile behavior of growing nerve tips expands the front margins of the neurite and generates mechanical forces that pull neurite components forwards. These activities promote the assembly and organization of cell components into the growing nerve fiber.
openaire   +1 more source

Axonal growth: where neurotrophins meet Wnts

Current Opinion in Cell Biology, 2005
Axonal guidance is influenced by many cues, including polypeptide trophic factors, cytokines, diffusible attractants and repellents and changes in calcium. How these signals are conveyed and integrated is not well defined. Recent data suggest that molecules of the canonical Wnt signaling pathway may have direct actions on axonal growth through ...
Juan Carlos, Arévalo, Moses V, Chao
openaire   +2 more sources

Signaling Mechanisms of Axon Growth Inhibition

Drug News & Perspectives, 2006
Generally, the axons in the adult mammalian central nervous system (CNS) do not regenerate after injuries. This lack of regeneration results in partial disability or complete paralysis. To date, several axon growth inhibitors that are known to inhibit axon regeneration in the CNS have been identified in the myelin.
K, Hata, T, Kubo, A, Yamaguchi, T, Yamashita   +3 more
openaire   +2 more sources

Microtubules Direct Axon Growth

Science's STKE, 2004
Two groups investigated mechanisms by which microtubules may be regulated in response to signals that promote axonal movement (see Kalil and Dent). Lee et al. identified the microtubule-associated protein orbit (also known as mast and the ortholog of vertebrate CLASPs) in a genetic screen in Drosophila
openaire   +1 more source

Dissecting how signaling directs axon growth

Science, 2014
The axon guidance protein netrin binds to two receptors with different architectures, providing a basis for diverse signaling outcomes.
openaire   +1 more source

Role of Laminin for Axonal Growth

1994
The basement membrane glycoprotein laminin has been shown in vitro to stimulate the growth or regeneration of neuronal processes [2], to act together with neurotrophic factors to promote neuronal survival [8] and to stimulate the proliferation of glial cells [23].
D, Edgar, J, Carter, S, Runswick, P, Ybot   +3 more
openaire   +2 more sources