Results 311 to 320 of about 6,133,766 (357)

The endocannabinoid system regulates both ependymoglial and neuronal cell responses to a tail amputation in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background The endocannabinoid system is a neuromodulatory system implicated in cellular processes during both development and regeneration. The Mexican axolotl, one of only a few vertebrates capable of central nervous system regeneration, was used to examine the role of the endocannabinoid system in the regeneration of the tail and spinal ...
Michael Tolentino, Sarah E. Walker, Gaynor E. Spencer, Robert Carlone   +3 more
wiley   +1 more source

Exploring biomarkers of neurodegeneration in epilepsy: Critical insights

Epileptic Disorders, EarlyView.
Abstract The advent of biofluid biomarkers for neurodegenerative disorders has precipitated a surge in recent evidence regarding their role in epilepsy. In this literature review, we examine the diagnostic, prognostic, and therapeutic potential of several biomarkers, including amyloid‐beta (Aβ) protein, total (t‐tau), phosphorylated tau (p‐tau) protein,
Rida Farhan, Syeda Amrah Hashmi, Jaideep Kapur, Anelyssa D'Abreu, Vineet Punia, Carol Manning, Vanessa L. Smith, Ifrah Zawar   +7 more
wiley   +1 more source

Timing is everything: The effect of early‐life seizures on developing neuronal circuits subserving spatial memory

Epilepsia Open, EarlyView.
Abstract Spatial memory, the aspect of memory involving encoding and retrieval of information regarding one's environment and spatial orientation, is a complex biological function incorporating multiple neuronal networks. Hippocampus‐dependent spatial memory is not innate and emerges during development in both humans and rodents.
Gregory L. Holmes
wiley   +1 more source

Exploring the Neuroprotective Role of Selenium: Implications and Perspectives for Central Nervous System Disorders

Exploration, EarlyView.
Selenium (Se) is a crucial element in selenoproteins, key biomolecules for physiological function in vivo. Central nervous system can express all 25 kinds of selenoproteins, which protect neurons by reducing oxidative stress and inflammatory response. Neuroprotection is being investigated through the biological study of Se.
Guanning Huang, Ying Liu, Xiadong Zhu, Lizhen He, Tianfeng Chen   +4 more
wiley   +1 more source

Structurally and Functionally Adaptive Biomimetic Periosteum: Materials, Fabrication, and Construction Strategies

Exploration, EarlyView.
Schematic illustration of structural and functional biomimicry. The upper part shows BP with various structures such as monolayered, surface‐microstructural, bilayered and multilayered. The bottom part exhibits BP with different functions including immune regulation, drugs/cells/factors/ions loading, as well as bioelectrical stimulation and ...
Yuhan Du, Yujie Liu, Yuanchi Zhang, Yangyi Nie, Zili Xu, Ling Qin, Wei Zhang, Yuxiao Lai   +7 more
wiley   +1 more source

Dual‐Responsive Multi‐Functional Silica Nanoparticles With Repaired Mitochondrial Functions for Efficient Alleviation of Spinal Cord Injury

Exploration, EarlyView.
Targeting mitochondrial dysfunction presents a potential therapeutic approach for treating spinal cord injury. We have successfully designed and synthesized a functional Se@NADH nanodrug system. This system offers neuroprotective and neuroregenerative benefits by modulating mitochondrial function and neutralizing reactive oxygen species, thereby ...
Guibin Gao, Juanjuan Li, Yanming Ma, Min Xie, Jianxian Luo, Ke Wang, Cheng Peng, Hua Yang, Tianjun Chen, Guowei Zhang, Jiang Ouyang, Hongsheng Lin, Zhisheng Ji   +12 more
wiley   +1 more source

Neuroprotective Properties of Wild Mango (Mangifera caloneura Kurz) Leaves on Alleviating Urban Air Pollutant Toxicity: Insights From Transcriptome Analysis of a Human Neuronal Cell Model

Food Frontiers, EarlyView.
ABSTRACT Exposure to urban air pollution, particularly particulate matter (PM), has been correlated with an increased risk of neurodegenerative diseases, notably Alzheimer's and Parkinson's diseases. However, the mechanisms underlying the association between urban air pollution and neurodegenerative diseases remain unclear.
Parinee Kittimongkolsuk, Suporn Sukjamnong, Sakawrat Janpaijit, Panthakarn Rangsinth, Sawarin Chumpolphant, Kamonwan Chaikhong, George Pak‐Heng Leung, Valerie W. Hu, Tewarit Sarachana, Anchalee Prasansuklab, Tewin Tencomnao   +10 more
wiley   +1 more source

A switchable multifunctional artificial neuron with rate coding and time‐to‐first‐spike coding for accurate image recognition

FlexMat, EarlyView.
A switchable multifunctional artificial neuron device is presented. This device can switch between volatile and non‐volatile modes by changing the position of the electrode contacts. Based on the multi‐functionality of the device, rate coding and time‐to‐first‐spike (TTFS) coding were respectively implemented and applied to image recognition, this ...
Weiqi Liu, Chenhui Xu, Weidong Xie, Jiabin Ye, Zhiwei Zhu, Zhenyuan Lin, Huipeng Chen   +6 more
wiley   +1 more source

The Aquaporin‐4 Expression and Localization in the Olfactory Epithelium Modulate the Odorant‐Evoked Responses and Olfactory‐Driven Behavior

Glia, EarlyView.
ABSTRACT Aquaporin‐4 (AQP4) is a water‐selective channel expressed in glial cells throughout the central nervous system (CNS). It serves as the primary water channel in the neuropil and plays roles in physiological functions, including regulating water homeostasis by adjusting cell volume and modulating neuronal activity. Different isoforms of AQP4 are
Donatella Lobraico, Pasqua Abbrescia, Maria Grazia Fioriello, Barbara Barile, Claudia Palazzo, Onofrio Valente, Grazia Paola Nicchia, Michele Dibattista, Antonio Frigeri   +8 more
wiley   +1 more source

Myelin Formation by Oligodendrocytes Is Enhanced Through Laminin‐411 and Its Derived Peptide

Glia, EarlyView.
Laminin (LM) α1, α2, and α4 chains are expressed at the myelination stage of oligodendrocyte (OL). LM411 and its E8 fragment enhance OL myelin membrane formation. A4G47 from LM411E8 is a novel peptide that promotes OL myelin formation. ABSTRACT In the central nervous system, oligodendrocytes (OLs) form myelin sheaths that accomplish the efficient ...
Binri Sasaki, Momo Oishi, Tomoka Aoki, Mai Hyodo, Chinami Onchi, Nanako Yamada, Hitomi Misawa, Momona Yamada, Chikako Hayashi, Kiyotoshi Sekiguchi, Keisuke Hamada, Yuji Yamada, Yamato Kikkawa, Motoyoshi Nomizu, Nobuharu Suzuki   +14 more
wiley   +1 more source