Results 31 to 40 of about 6,093,797 (222)
PLoS Genetics, 2022 Axon and dendrite development require the cooperation of actin and microtubule cytoskeletons. Microtubules form a well-organized network to direct polarized trafficking and support neuronal processes formation with distinct actin structures.
Chih-Hsien Lin +3 more
doaj +1 more source
A model of fasciculation and sorting in mixed populations of axons [PDF]
Phys. Rev. E 84, 021908 (2011), 2010 We extend a recently proposed model (Chaudhuri et al., EPL 87, 20003 (2009)) aiming to describe the formation of fascicles of axons during neural development. The growing axons are represented as paths of interacting directed random walkers in two spatial dimensions.
arxiv +1 more source
Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment
Journal of Neuroscience, 2019 cAMP signaling is known to be critical in neuronal survival and axon growth. Increasingly the subcellular compartmentation of cAMP signaling has been appreciated, but outside of dendritic synaptic regulation, few cAMP compartments have been defined in ...
T. Boczek +11 more
semanticscholar +1 more source
Physiologic Electrical Fields Direct Retinal Ganglion Cell Axon Growth In Vitro
Investigative Ophthalmology and Visual Science, 2019 Purpose The purpose of this study was to characterize the ability of applied electrical fields (EFs) to direct retinal ganglion cell (RGC) axon growth as well as to assess whether Rho GTPases play a role in translating electrical cues to directional cues.
K. Gokoffski +4 more
semanticscholar +1 more source
bioRxiv, 2019 While axon regeneration is a key determinant of functional recovery of the nervous system after injury, it is often poor in the mature nervous system. Influx of extracellular calcium (Ca2+) is one of the first phenomena that occur following axonal injury,
Feng Xi +17 more
semanticscholar +1 more source
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
eLife, 2019 Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored.
Marta Palomo-Guerrero +12 more
semanticscholar +1 more source
Anomalous diffusion for neuronal growth on surfaces with controlled geometries [PDF]
Published in PLOS ONE, 14(5), e0216181, May 6, 2019, 2019 Geometrical cues are known to play a very important role in neuronal growth and the formation of neuronal networks. Here, we present a detailed analysis of axonal growth and dynamics for neuronal cells cultured on patterned polydimethylsiloxane surfaces.
arxiv +1 more source
Regulation of axon growth by myosin II–dependent mechanocatalysis of cofilin activity
Journal of Cell Biology, 2019 Synergism between myosin II contractility and cofilin activity modulates serotonin-dependent axon growth. Normally, cofilin-dependent decreases in actin density are compensated by increases in point contact density and traction force; however, myosin ...
Xiao-Feng Zhang +7 more
semanticscholar +1 more source
Graphene promotes axon elongation through local stall of Nerve Growth Factor signaling endosomes [PDF]
, 2020 Several works reported increased differentiation of neuronal cells grown on graphene; however, the molecular mechanism driving axon elongation on this material has remained elusive. Here, we study the axonal transport of nerve growth factor (NGF), the neurotrophin supporting development of peripheral neurons, as a key player in the time course of ...
arxiv +1 more source
Harnessing neurovascular interaction to guide axon growth
Scientific Reports, 2019 Regulating the intrinsic interactions between blood vessels and nerve cells has the potential to enhance repair and regeneration of the central nervous system.
Paul P. Partyka +7 more
semanticscholar +1 more source