Results 31 to 40 of about 6,316,330 (345)
N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons
Biology Open, 2015 Axonogenesis, a process for the establishment of neuron connectivity, is central to brain function. The role of metabolites derived from docosahexaenoic acid (DHA, 22:6n-3) that is specifically enriched in the brain, has not been addressed in axon ...
Giorgi Kharebava +5 more
doaj +1 more source
eLife, 2019 EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/γ-secretase is required for axon growth in the developing mouse brain.
Míriam Javier-Torrent +7 more
doaj +1 more source
Deacetylation of Miro1 by HDAC6 blocks mitochondrial transport and mediates axon growth inhibition
Journal of Cell Biology, 2019 Extracellular stimuli in the injured CNS, such as chondroitin sulfate proteoglycans, inhibit axon growth through activation of the small GTPase RhoA.
Ashley L. Kalinski +19 more
semanticscholar +1 more source
The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches
Cell Reports, 2019 Summary: In developing neurons, phosphoinositide 3-kinases (PI3Ks) control axon growth and branching by positively regulating PI3K/PI(3,4,5)P3, but how neurons are able to generate sufficient PI(3,4,5)P3 in the presence of high levels of the antagonizing
Annika Brosig +19 more
doaj +1 more source
Genome-wide chromatin accessibility analyses provide a map for enhancing optic nerve regeneration
Scientific Reports, 2021 Retinal Ganglion Cells (RGCs) lose their ability to grow axons during development. Adult RGCs thus fail to regenerate their axons after injury, leading to vision loss.
Wolfgang Pita-Thomas +4 more
doaj +1 more source
Prenylation of Axonally Translated Rac1 Controls NGF-Dependent Axon Growth [PDF]
Developmental Cell, 2020 Compartmentalized signaling is critical for cellular organization and specificity of functional outcomes in neurons. Here, we report that post-translational lipidation of newly synthesized proteins in axonal compartments allows for short-term and autonomous responses to extrinsic cues. Using conditional mutant mice, we found that protein prenylation is
Emily, Scott-Solomon, Rejji, Kuruvilla
openaire +2 more sources
PLoS Genetics, 2022 Axon and dendrite development require the cooperation of actin and microtubule cytoskeletons. Microtubules form a well-organized network to direct polarized trafficking and support neuronal processes formation with distinct actin structures.
Chih-Hsien Lin +3 more
doaj +1 more source
Regulation of Neuronal Survival and Axon Growth by a Perinuclear cAMP Compartment
Journal of Neuroscience, 2019 cAMP signaling is known to be critical in neuronal survival and axon growth. Increasingly the subcellular compartmentation of cAMP signaling has been appreciated, but outside of dendritic synaptic regulation, few cAMP compartments have been defined in ...
T. Boczek +11 more
semanticscholar +1 more source
Physiologic Electrical Fields Direct Retinal Ganglion Cell Axon Growth In Vitro
Investigative Ophthalmology and Visual Science, 2019 Purpose The purpose of this study was to characterize the ability of applied electrical fields (EFs) to direct retinal ganglion cell (RGC) axon growth as well as to assess whether Rho GTPases play a role in translating electrical cues to directional cues.
K. Gokoffski +4 more
semanticscholar +1 more source
Sensing of nutrients by CPT1C regulates late endosome/lysosome anterograde transport and axon growth
eLife, 2019 Anterograde transport of late endosomes or lysosomes (LE/Lys) is crucial for proper axon growth. However, the role of energetic nutrients has been poorly explored.
Marta Palomo-Guerrero +12 more
semanticscholar +1 more source