Results 21 to 30 of about 117,469 (259)

Genome-wide chromatin accessibility analyses provide a map for enhancing optic nerve regeneration

Scientific Reports, 2021
Retinal Ganglion Cells (RGCs) lose their ability to grow axons during development. Adult RGCs thus fail to regenerate their axons after injury, leading to vision loss.
Wolfgang Pita-Thomas, Tassia Mangetti Gonçalves, Ajeet Kumar, Guoyan Zhao, Valeria Cavalli   +4 more
doaj   +1 more source

TIAM-1 differentially regulates dendritic and axonal microtubule organization in patterning neuronal development through its multiple domains.

PLoS Genetics, 2022
Axon and dendrite development require the cooperation of actin and microtubule cytoskeletons. Microtubules form a well-organized network to direct polarized trafficking and support neuronal processes formation with distinct actin structures.
Chih-Hsien Lin, Ying-Chun Chen, Shih-Peng Chan, Chan-Yen Ou   +3 more
doaj   +1 more source

Zeb2 is a negative regulator of midbrain dopaminergic axon growth and target innervation

Scientific Reports, 2017
Neural connectivity requires neuronal differentiation, axon growth, and precise target innervation. Midbrain dopaminergic neurons project via the nigrostriatal pathway to the striatum to regulate voluntary movement.
Shane V. Hegarty, Sean L. Wyatt, Laura Howard, Elke Stappers, Danny Huylebroeck, Aideen M. Sullivan, Gerard W. O’Keeffe   +6 more
doaj   +1 more source

Transient axonal glycoprotein-1 (TAG-1) and laminin-α1 regulate dynamic growth cone behaviors and initial axon direction in vivo

Neural Development, 2008
Background How axon guidance signals regulate growth cone behavior and guidance decisions in the complex in vivo environment of the central nervous system is not well understood.
Yost H Joseph, Essner Jeffrey J, Sittaramane Vinoth K, Wolman Marc A, Chandrasekhar Anand, Halloran Mary C   +5 more
doaj   +1 more source

Tissue Engineered Axon Tracts Serve as Living Scaffolds to Accelerate Axonal Regeneration and Functional Recovery Following Peripheral Nerve Injury in Rats

Frontiers in Bioengineering and Biotechnology, 2020
Strategies to accelerate the rate of axon regeneration would improve functional recovery following peripheral nerve injury, in particular for cases involving segmental nerve defects.
Kritika S. Katiyar, Kritika S. Katiyar, Kritika S. Katiyar, Laura A. Struzyna, Laura A. Struzyna, Laura A. Struzyna, Joseph P. Morand, Justin C. Burrell, Justin C. Burrell, Justin C. Burrell, Basak Clements, Franco A. Laimo, Franco A. Laimo, Kevin D. Browne, Kevin D. Browne, Joachim Kohn, Zarina Ali, Harry C. Ledebur, Douglas H. Smith, Douglas H. Smith, D. Kacy Cullen, D. Kacy Cullen, D. Kacy Cullen, D. Kacy Cullen   +23 more
doaj   +1 more source

MiR-124 Promotes the Growth of Retinal Ganglion Cells Derived from Müller Cells

Cellular Physiology and Biochemistry, 2018
Background/Aims: Retinal Müller cells could be induced to differentiate into retinal ganglion cells (RGCs), but RGCs derived from Müller cells have defects in axon growth, leading to a defect in signal conduction.
Ye He, Hai-bo Li, Xin Li, Yi Zhou, Xiao-bo Xia, Wei-tao Song   +5 more
doaj   +1 more source

Intrinsic Axonal Growth and the Drive for Regeneration [PDF]

Frontiers in Neuroscience, 2016
Following damage to the adult nervous system in conditions like stroke, spinal cord injury, or traumatic brain injury, many neurons die and most of the remaining spared neurons fail to regenerate. Injured neurons fail to regrow both because of the inhibitory milieu in which they reside as well as a loss of the intrinsic growth capacity of the neurons ...
openaire   +3 more sources

Chemokines induce axon outgrowth downstream of Hepatocyte Growth Factor and TCF/β-catenin signaling

Frontiers in Cellular Neuroscience, 2013
Axon morphogenesis is a complex process regulated by a variety of secreted molecules, including morphogens and growth factors, resulting in the establishment of the neuronal circuitry. Our previous work demonstrated that growth factors (Neurotrophins (NT)
Deepshikha eBhardwaj, Mireia eNáger, Judith eCamats, Monica Delia David, Alberto eBenguria, Ana eDopazo, Carles eCantí, Judit eHerreros   +7 more
doaj   +1 more source

Modeling the Axon as an Active Partner with the Growth Cone in Axonal Elongation [PDF]

Biophysical Journal, 2018
Forces generated by the growth cone are vital for the proper development of the axon and thus brain function. Although recent experiments show that forces are generated along the axon, it is unknown whether the axon plays a direct role in controlling growth cone advance.
Rijk, de Rooij, Ellen, Kuhl, Kyle E, Miller   +2 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source