Results 11 to 20 of about 117,469 (259)
T-type Ca2+ channels are required for enhanced sympathetic axon growth by TNFα reverse signalling [PDF]
Open Biology, 2017 Tumour necrosis factor receptor 1 (TNFR1)-activated TNFα reverse signalling, in which membrane-integrated TNFα functions as a receptor for TNFR1, enhances axon growth from developing sympathetic neurons and plays a crucial role in establishing ...
Lilian Kisiswa +6 more
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p250GAP is a novel player in the Cdh1-APC/Smurf1 pathway of axon growth regulation. [PDF]
PLoS ONE, 2012 Axon growth is an essential process during brain development. The E3 ubiquitin ligase Cdh1-APC has emerged as a critical regulator of intrinsic axon growth control.
Madhuvanthi Kannan +4 more
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The Virtuous Cycle of Axon Growth: Axonal Transport of Growth‐Promoting Machinery as an Intrinsic Determinant of Axon Regeneration [PDF]
Developmental Neurobiology, 2018 ABSTRACTInjury to the brain and spinal cord has devastating consequences because adult central nervous system (CNS) axons fail to regenerate. Injury to the peripheral nervous system (PNS) has a better prognosis, because adult PNS neurons support robust axon regeneration over long distances.
Petrova, Veselina, Eva, R
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Axonal growth and its inhibition [PDF]
Eye, 1994 neu ropil which may be either white or grey matter. Functional regeneration is a corollary defined as the invasion of regenerating fibres into the original or new targets, where synaptic connections are established which restore lost function. Regeneration ofaxons in the mammalian and avian eNS is, however, largely impossible, but the reasons for this
M, Berry, S, Hall, D, Shewan, J, Cohen
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A Simple Method for 3D Analysis of Immunolabeled Axonal Tracts in a Transparent Nervous System
Cell Reports, 2014 Clearing techniques have been developed to transparentize mouse brains, thereby preserving 3D structure, but their complexity has limited their use. Here, we show that immunolabeling of axonal tracts followed by optical clearing with solvents (3DISCO ...
Morgane Belle +7 more
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Axon Stretch Growth: The Mechanotransduction of Neuronal Growth [PDF]
Journal of Visualized Experiments, 2011 During pre-synaptic embryonic development, neuronal processes traverse short distances to reach their targets via growth cone. Over time, neuronal somata are separated from their axon terminals due to skeletal growth of the enlarging organism (Weiss 1941; Gray, Hukkanen et al. 1992).
Loverde, Joseph R. +2 more
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eLife, 2016 Mechanistic studies of axon growth during development are beneficial to the search for neuron-intrinsic regulators of axon regeneration. Here, we discovered that, in the developing neuron from rat, Akt signaling regulates axon growth and growth cone ...
Hyo Rim Ko +9 more
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N-docosahexaenoylethanolamine regulates Hedgehog signaling and promotes growth of cortical axons
Biology Open, 2015 Axonogenesis, a process for the establishment of neuron connectivity, is central to brain function. The role of metabolites derived from docosahexaenoic acid (DHA, 22:6n-3) that is specifically enriched in the brain, has not been addressed in axon ...
Giorgi Kharebava +5 more
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eLife, 2019 EphA/ephrin signaling regulates axon growth and guidance of neurons, but whether this process occurs also independently of ephrins is unclear. We show that presenilin-1 (PS1)/γ-secretase is required for axon growth in the developing mouse brain.
Míriam Javier-Torrent +7 more
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The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches
Cell Reports, 2019 Summary: In developing neurons, phosphoinositide 3-kinases (PI3Ks) control axon growth and branching by positively regulating PI3K/PI(3,4,5)P3, but how neurons are able to generate sufficient PI(3,4,5)P3 in the presence of high levels of the antagonizing
Annika Brosig +19 more
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