Moving CNS axon growth and regeneration research into human model systems [PDF]
Frontiers in Neuroscience, 2023 Axon regeneration is limited in the adult mammalian central nervous system (CNS) due to both intrinsic and extrinsic factors. Rodent studies have shown that developmental age can drive differences in intrinsic axon growth ability, such that embryonic ...
Bo P. Lear, Darcie L. Moore
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Capacity of astrocytes to promote axon growth in the injured mammalian central nervous system [PDF]
Frontiers in Neuroscience, 2022 Understanding the regulation of axon growth after injury to the adult central nervous system (CNS) is crucial to improve neural repair. Following acute focal CNS injury, astrocytes are one cellular component of the scar tissue at the primary lesion that ...
Matin Hemati-Gourabi +5 more
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Cytosolic Ptbp2 modulates axon growth in motoneurons through axonal localization and translation of Hnrnpr [PDF]
Nature Communications, 2023 The neuronal RNA-binding protein Ptbp2 regulates neuronal differentiation by modulating alternative splicing programs in the nucleus. Such programs contribute to axonogenesis by adjusting the levels of protein isoforms involved in axon growth and ...
Saeede Salehi +9 more
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Cbln1 regulates axon growth and guidance in multiple neural regions. [PDF]
PLoS Biology, 2022 The accurate construction of neural circuits requires the precise control of axon growth and guidance, which is regulated by multiple growth and guidance cues during early nervous system development.
Peng Han +9 more
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Astroglial exosome HepaCAM signaling and ApoE antagonization coordinates early postnatal cortical pyramidal neuronal axon growth and dendritic spine formation [PDF]
Nature Communications, 2023 Developing astroglia play important roles in regulating synaptogenesis through secreted and contact signals. Whether they regulate postnatal axon growth is unknown. By selectively isolating exosomes using size-exclusion chromatography (SEC) and employing
Shijie Jin +5 more
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Frontiers in Molecular Neuroscience, 2012 Axon growth requires coordinated regulation of gene expression in the neuronal soma, anterograde transport of synthesized raw materials along the axon, and assembly of cytoskeleton and membranes in the nerve growth cone. Glycogen synthase kinase 3 (GSK3)
Fengquan eZhou
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Promotion of Axon Growth by the Secreted End of a Transcription Factor
Cell Reports, 2019 Summary: Axon growth is regulated externally by attractive and repulsive cues generated in the environment. In addition, intrinsic pathways govern axon development, although the extent to which axons themselves can influence their own growth is unknown ...
Ethan P. McCurdy +3 more
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Non-Muscle Myosin II in Axonal Cell Biology: From the Growth Cone to the Axon Initial Segment
Cells, 2020 By binding to actin filaments, non-muscle myosin II (NMII) generates actomyosin networks that hold unique contractile properties. Their dynamic nature is essential for neuronal biology including the establishment of polarity, growth cone formation and ...
Ana Rita Costa, Monica M. Sousa
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The ANC-1 (Nesprin-1/2) organelle-anchoring protein functions through mitochondria to polarize axon growth in response to SLT-1. [PDF]
PLoS Genetics, 2022 A family of giant KASH proteins, including C. elegans ANC-1 and mammalian Nesprin-1 and -2, are involved in organelle anchoring and are associated with multiple neurodevelopmental disorders including autism, bipolar disorder, and schizophrenia.
Nathan C Fischer +6 more
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Sound of an axon's growth [PDF]
Physical Review E, 2019 Axons are linear structures of nerve cells that can range from a few tens of micrometers up to meters in length. In addition to external cues, the length of an axon is also regulated by unknown internal mechanisms. Molecular motors have been suggested to generate oscillations with an axon-length-dependent frequency that could be used to measure an axon'
Folz, Frederic +3 more
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