Results 41 to 50 of about 6,093,797 (222)
Neural Development, 2008 Background How axon guidance signals regulate growth cone behavior and guidance decisions in the complex in vivo environment of the central nervous system is not well understood.
Yost H Joseph +5 more
doaj +1 more source
Frontiers in Bioengineering and Biotechnology, 2020 Strategies to accelerate the rate of axon regeneration would improve functional recovery following peripheral nerve injury, in particular for cases involving segmental nerve defects.
Kritika S. Katiyar +23 more
doaj +1 more source
Scientific Reports, 2018 The failure of axon regeneration in the CNS limits recovery from damage and disease. Members of the KLF family of transcription factors can exert both positive and negative effects on axon regeneration, but the underlying mechanisms are unclear.
Zimei Wang +8 more
semanticscholar +1 more source
Neuron Growth Output-Feedback Control by PDE Backstepping [PDF]
arXiv, 2022 Neurological injuries predominantly result in loss of functioning of neurons. These neurons may regain function after particular medical therapeutics, such as Chondroitinase ABC (ChABC), that promote axon elongation by manipulating the extracellular matrix, the network of extracellular macromolecules, and minerals that control the tubulin protein ...
arxiv
Stochastic Models of Neuronal Growth [PDF]
arXiv, 2022 Neurons are the basic cells of the nervous system. During their growth neurons extend two types of processes: axons and dendrites, which navigate to other neurons and form complex neuronal networks that transmit electrical signals throughout the body. The basic process underlying the network formation is axonal growth, a process involving the extension
arxiv
The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration
Investigative Ophthalmology and Visual Science, 2018 Purpose Adult central nervous system (CNS) neurons are unable to regenerate their axons after injury. Krüppel-like transcription factor (KLF) family members regulate intrinsic axon growth ability in vitro and in vivo, but mechanisms downstream of these ...
J. Galvao +9 more
semanticscholar +1 more source
MiR-124 Promotes the Growth of Retinal Ganglion Cells Derived from Müller Cells
Cellular Physiology and Biochemistry, 2018 Background/Aims: Retinal Müller cells could be induced to differentiate into retinal ganglion cells (RGCs), but RGCs derived from Müller cells have defects in axon growth, leading to a defect in signal conduction.
Ye He +5 more
doaj +1 more source
IGFBPL1 Regulates Axon Growth through IGF-1-mediated Signaling Cascades
Scientific Reports, 2018 Activation of axonal growth program is a critical step in successful optic nerve regeneration following injury. Yet the molecular mechanisms that orchestrate this developmental transition are not fully understood.
Chenying Guo +12 more
semanticscholar +1 more source
Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration
Cell Death and Differentiation, 2018 Neurons in the central nervous system (CNS) lose their intrinsic ability and fail to regenerate, but the underlying mechanisms are largely unknown. Polycomb group (PcG) proteins, which include PRC1 and PRC2 complexes function as gene repressors and are ...
Run-Shan Duan +10 more
semanticscholar +1 more source
Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons
Cell Reports, 2015 Axon guidance relies on precise translation of extracellular signal gradients into local changes in cytoskeletal dynamics, but the molecular mechanisms regulating dose-dependent responses of growth cones are still poorly understood.
Martin Balastik +15 more
doaj +1 more source