Results 41 to 50 of about 6,316,330 (345)

Regulation of axon growth by myosin II–dependent mechanocatalysis of cofilin activity

Journal of Cell Biology, 2019
Synergism between myosin II contractility and cofilin activity modulates serotonin-dependent axon growth. Normally, cofilin-dependent decreases in actin density are compensated by increases in point contact density and traction force; however, myosin ...
Xiao-Feng Zhang, V. Ajeti, Nicole Tsai, A. Fereydooni, W. Burns, M. Murrell, E. M. De La Cruz, P. Forscher   +7 more
semanticscholar   +1 more source

Calcium/calmodulin-dependent protein kinase II regulates mammalian axon growth by affecting F-actin length in growth cone

bioRxiv, 2019
While axon regeneration is a key determinant of functional recovery of the nervous system after injury, it is often poor in the mature nervous system. Influx of extracellular calcium (Ca2+) is one of the first phenomena that occur following axonal injury,
Feng Xi, Renjie Xu, Renjie Xu, Jin-hui Xu, Weihua Wang, Jinjin Ma, Feng Wang, Yan-Xia Ma, Shi-Bin Qi, Jing-cheng Zhang, Haonan Zhang, Xu-Zhen Qin, Jianquan Chen, Bin Li, Chang‐Mei Liu, Huilin Yang, B. Meng, Saijilafu   +17 more
semanticscholar   +1 more source

Promotion of Axon Growth by the Secreted End of a Transcription Factor

Cell Reports, 2019
Summary: Axon growth is regulated externally by attractive and repulsive cues generated in the environment. In addition, intrinsic pathways govern axon development, although the extent to which axons themselves can influence their own growth is unknown ...
Ethan P. McCurdy, Kyung Min Chung, Carlos R. Benitez-Agosto, Ulrich Hengst   +3 more
doaj   +1 more source

Harnessing neurovascular interaction to guide axon growth

Scientific Reports, 2019
Regulating the intrinsic interactions between blood vessels and nerve cells has the potential to enhance repair and regeneration of the central nervous system.
Paul P. Partyka, Ying Jin, J. Bouyer, Angelica DaSilva, George A. Godsey, R. Nagele, I. Fischer, Peter A. Galie   +7 more
semanticscholar   +1 more source

Transient axonal glycoprotein-1 (TAG-1) and laminin-α1 regulate dynamic growth cone behaviors and initial axon direction in vivo

Neural Development, 2008
Background How axon guidance signals regulate growth cone behavior and guidance decisions in the complex in vivo environment of the central nervous system is not well understood.
Yost H Joseph, Essner Jeffrey J, Sittaramane Vinoth K, Wolman Marc A, Chandrasekhar Anand, Halloran Mary C   +5 more
doaj   +1 more source

Tissue Engineered Axon Tracts Serve as Living Scaffolds to Accelerate Axonal Regeneration and Functional Recovery Following Peripheral Nerve Injury in Rats

Frontiers in Bioengineering and Biotechnology, 2020
Strategies to accelerate the rate of axon regeneration would improve functional recovery following peripheral nerve injury, in particular for cases involving segmental nerve defects.
Kritika S. Katiyar, Kritika S. Katiyar, Kritika S. Katiyar, Laura A. Struzyna, Laura A. Struzyna, Laura A. Struzyna, Joseph P. Morand, Justin C. Burrell, Justin C. Burrell, Justin C. Burrell, Basak Clements, Franco A. Laimo, Franco A. Laimo, Kevin D. Browne, Kevin D. Browne, Joachim Kohn, Zarina Ali, Harry C. Ledebur, Douglas H. Smith, Douglas H. Smith, D. Kacy Cullen, D. Kacy Cullen, D. Kacy Cullen, D. Kacy Cullen   +23 more
doaj   +1 more source

Mechanosensing is critical for axon growth in the developing brain

Nature Neuroscience, 2016
During nervous system development, neurons extend axons along well-defined pathways. The current understanding of axon pathfinding is based mainly on chemical signaling.
David E. Koser, Amelia J Thompson, Sarah K. Foster, A. Dwivedy, Eva K Pillai, G. Sheridan, H. Svoboda, M. Viana, Luciano da F. Costa, J. Guck, C. Holt, K. Franze   +11 more
semanticscholar   +1 more source

KLF6 and STAT3 co-occupy regulatory DNA and functionally synergize to promote axon growth in CNS neurons

Scientific Reports, 2018
The failure of axon regeneration in the CNS limits recovery from damage and disease. Members of the KLF family of transcription factors can exert both positive and negative effects on axon regeneration, but the underlying mechanisms are unclear.
Zimei Wang, Vatsal Mehra, M. T. Simpson, Brian Maunze, Advaita Chakraborty, Lyndsey Holan, Erik Eastwood, Murray G. Blackmore, Ishwariya Venkatesh   +8 more
semanticscholar   +1 more source

IGFBPL1 Regulates Axon Growth through IGF-1-mediated Signaling Cascades

Scientific Reports, 2018
Activation of axonal growth program is a critical step in successful optic nerve regeneration following injury. Yet the molecular mechanisms that orchestrate this developmental transition are not fully understood.
Chenying Guo, Kin-Sang Cho, Yingqian Li, Kissauo Tchedre, C. Antolik, Jie Ma, Justin Chew, T. Utheim, Xizhong A. Huang, Honghua Yu, M. T. A. Malik, Nada Anzak, D. Chen   +12 more
semanticscholar   +1 more source

Axon Stretch Growth: The Mechanotransduction of Neuronal Growth [PDF]

Journal of Visualized Experiments, 2011
During pre-synaptic embryonic development, neuronal processes traverse short distances to reach their targets via growth cone. Over time, neuronal somata are separated from their axon terminals due to skeletal growth of the enlarging organism (Weiss 1941; Gray, Hukkanen et al. 1992).
Loverde, Joseph R., Tolentino, Rosa E., Pfister, Bryan J.   +2 more
openaire   +2 more sources