Results 121 to 130 of about 968,571 (396)
A Fractional Viscoelastic Model Of The Axon In Brain White Matter [PDF]
arXiv, 2023 Traumatic axonal injury occurs when loads experienced on the tissue-scale are transferred to the individual axons. Mechanical characterization of axon deformation especially under dynamic loads however is extremely difficult owing to their viscoelastic properties.
arxiv
eLife, 2016 RNA-binding proteins (RBPs) control multiple aspects of post-transcriptional gene regulation and function during various biological processes in the nervous system.
Janelle C Leggere +5 more
semanticscholar +1 more source
Axon Guidance: Gained in Translation [PDF]
Neuron, 2018 In this issue of Neuron, Cagnetta et al. (2018) describe a novel method to identify, in an unbiased manner, newly synthesized axonal proteins in response to axon guidance cues. They find that axons stimulated by different guidance cues (Netrin-1, BDNF, and Sema3A) show distinct and common signatures.
Frédéric Charron, Frédéric Charron
openaire +2 more sources
Downstream of Guidance Receptors Entering the Baroque Period of Axon Guidance Signaling [PDF]
, 2003 The Roundabout (“Robo”) family of transmembrane proteins are the receptors and mediators of the repellent axon guidance signal Slit. However, the molecular mechanisms by which Robo signaling leads to growth cone or neuron repulsion are still poorly ...
Schmucker, Dietmar
core +1 more source
Advanced Healthcare Materials, EarlyView.Through tuning biomimetic scaffold stiffness and matrix composition the reparative capacity of astrocyte progenitors is enhanced. Soft, collagen‐IV/fibronectin‐functionalized scaffolds promote progenitor growth while improving angiogenic, immunomodulatory, and neurotrophic capacity in a stiffness and matrix‐dependent manner, demonstrating the impact of
Cian O'Connor +10 more
wiley +1 more source
Molecular Neurodegeneration, 2011 Background The β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral β-amyloid (Aβ) levels in Alzheimer's disease (AD).
Rajapaksha Tharinda W +3 more
doaj +1 more source
Microtubule dynamics in axon guidance [PDF]
Neuroscience Bulletin, 2014 Precise modulation of the cytoskeleton is involved in a variety of cellular processes including cell division, migration, polarity, and adhesion. In developing post-mitotic neurons, extracellular guidance cues not only trigger signaling cascades that act at a distance to indirectly regulate microtubule distribution, and assembly and disassembly in the ...
Trisha Dwyer, Guofa Liu
openaire +3 more sources
Advanced Materials, EarlyView.A novel one‐shot integration electropolymerization (OSIEP) method is developed as a breakthrough on the intricate photolithographic steps, enabling to compress all processes from synthesis to channel integration in one‐shot manufacturing. The specially designed dual bipolar electrodes provide the targeted depositions of poly(3,4‐ethylenedioxythiophene)
Jiyun Lee +9 more
wiley +1 more source
Plexin B3 guides axons to cross the midline in vivo
Frontiers in Cellular NeuroscienceDuring the development of neural circuits, axons are guided by a variety of molecular cues to navigate through the brain and establish precise connections with correct partners at the right time and place. Many axon guidance cues have been identified and
Zhi-Zhi Liu +21 more
doaj +1 more source
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics
Communications Biology, 2021 Huang et al demonstrate that glioblastoma cells upregulate axon guidance molecule Plexin-B2 to gain invasiveness and that Plexin-B2 promotes glioblastoma cell infiltration along axon fiber tracts in intracranial transplant models by modulating cellular ...
Yong Huang +14 more
doaj +1 more source