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Cell and Tissue Research, 1997
The segmental arrangement of spinal nerves in higher vertebrate embryos provides a simple system in which to study the factors that influence axon pathfinding. Developing motor and sensory axons are intimately associated with surrounding tissues that direct axon guidance. We argue that two distinct guidance mechanisms, viz.
, Tannahill, , Cook, , Keynes
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The segmental arrangement of spinal nerves in higher vertebrate embryos provides a simple system in which to study the factors that influence axon pathfinding. Developing motor and sensory axons are intimately associated with surrounding tissues that direct axon guidance. We argue that two distinct guidance mechanisms, viz.
, Tannahill, , Cook, , Keynes
openaire +3 more sources
European Journal of Neuroscience, 1997
AbstractAxon guidance by target‐derived diffusible factors plays an important role in the development of the nervous system. This paper considers the constraints imposed on this process by the mathematics of diffusion. A point source continuously producing a factor into an infinite three‐dimensional volume is considered as a model for both the in vivo ...
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AbstractAxon guidance by target‐derived diffusible factors plays an important role in the development of the nervous system. This paper considers the constraints imposed on this process by the mathematics of diffusion. A point source continuously producing a factor into an infinite three‐dimensional volume is considered as a model for both the in vivo ...
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Molecular Mechanisms of Axon Guidance
Science, 2002Axons are guided along specific pathways by attractive and repulsive cues in the extracellular environment. Genetic and biochemical studies have led to the identification of highly conserved families of guidance molecules, including netrins, Slits, semaphorins, and ephrins.
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Guidance of retinal axons in mammals
Seminars in Cell & Developmental Biology, 2019In order to navigate through the surrounding environment many mammals, including humans, primarily rely on vision. The eye, composed of the choroid, sclera, retinal pigmented epithelium, cornea, lens, iris and retina, is the structure that receives the light and converts it into electrical impulses.
Herrera, Eloisa +2 more
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The Molecular Biology of Axon Guidance
Science, 1996Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mechanisms: contact attraction, chemoattraction, contact repulsion, and chemorepulsion. Evidence is
M, Tessier-Lavigne, C S, Goodman
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Axon guidance: the cytoplasmic tail
Current Opinion in Cell Biology, 2002Recent advances in the study of axon guidance have begun to clarify the intricate signalling mechanisms utilised by receptors that mediate path-finding. Many of these axon guidance receptors, including Plexin B, EphA, ephrin B and Robo, regulate the Rho family of GTPases, to effect changes in motility. Recent studies demonstrate a critical role for the
Bharatkumar N, Patel +1 more
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Repellent cues in axon guidance
Current Opinion in Neurobiology, 1992There is increasing evidence that axons are guided by repulsion in several regions of the developing nervous system, although this has yet to be confirmed directly in vivo. As more candidate repulsion molecules are identified, it is becoming clear that collapse of the growth cone in vitro may be mediated by more than one intracellular mechanism.
R J, Keynes, G M, Cook
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A framework for simulating axon guidance
Neurocomputing, 2005We present an open-L-systems-based framework for modeling, simulating and visualizing axon guidance. It enables efficient integrative simulation of the two concurrent processes involved in axon guidance-the process of the extracellular environment and that of the growing neuron having its axon guided towards the target area by different mechanisms-and ...
Gangmin Ning
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