Quercetin Alleviates Diabetic Peripheral Neuropathy by Regulating Axon Guidance Factors and Inhibiting the Rho/ROCK Pathway in vivo and in vitro. [PDF]
Song W +8 more
europepmc +1 more source
Autonomous Polymer Frameworks for Sustainable Tissue‐Interfaced Plastic Bioelectronics
This review focuses on plastic bioelectronic systems integrated with autonomous polymer frameworks (auto‐POFs) and summarizes recent progress in this field. It provides an in‐depth analysis of the design strategies and operational mechanisms of auto‐POFs, highlighting their pivotal role in enhancing the sustainability and interfacial adaptability of ...
Elvis K. Boahen +8 more
wiley +1 more source
Tet controls axon guidance in early brain development through glutamatergic signaling. [PDF]
Tran H +4 more
europepmc +1 more source
RNAi Regulator C3PO Promotes Arbovirus Infection in Insect Vectors
RNA interference (RNAi) is vital for eukaryotes to defend against virus infection. The C3PO complex takes part in RNAi but its role in regulating viral infection remains unclear. This work finds that insect C3PO facilitates arbovirus replication by degrading precursors of miRNAs, especially miR‐971‐3p.
Yan Xiao +7 more
wiley +1 more source
UNC5C: Novel Gene Associated with Psychiatric Disorders Impacts Dysregulation of Axon Guidance Pathways. [PDF]
Treccarichi S +10 more
europepmc +1 more source
Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng +10 more
wiley +1 more source
A human DCC variant causing mirror movement disorder reveals that the WAVE regulatory complex mediates axon guidance by netrin-1-DCC. [PDF]
Chaudhari K +14 more
europepmc +1 more source
Repurposing of Chemokine Antagonists for Combined Phase‐Resolved Spinal Cord Injury Treatment
Spinal cord injury (SCI) in mammals is accompanied by a massive cytokine storm in cerebrospinal fluid, mainly driven by CXCL1, IL‐6, and CCL2‐5. Sub‐acute phase is mostly associated with IL‐2, IL‐7, CCL22, and CX3CL1, whereas TNFα and IL17α permanently persists in CNS even weeks following SCI.
Alexey A. Belogurov Jr. +20 more
wiley +1 more source

