Results 271 to 280 of about 41,593 (291)

Axonal growth and guidance [PDF]

Trends in Neurosciences, 1983
Abstract The motile behavior of growing nerve tips expands the front margins of the neurite and generates mechanical forces that pull neurite components forwards. These activities promote the assembly and organization of cell components into the growing nerve fiber.
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Axonal Guidance: Making Connections

2016
The vertebrate brain contains millions of neuronal and glial cells arranged in a highly organized manner forming functional neural circuits. To form these circuits during brain development, neurons extend an axon from the cell body to make connections with neurons in target brain areas, which can be a considerable distance away from the neuronal cell ...
Kozulin, Peter, Richards, Linda
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Calcium signaling in axon guidance

Trends in Neurosciences, 2014
Guidance of axons to their targets in the developing nervous system requires a myriad of downstream signaling molecules to coordinate growth cone movement. One of the most important of these is calcium, and over the past few years many new insights have been gained into the role of calcium in axon guidance.
Sutherland, Daniel J., Pujic, Zac, Goodhill, Geoffrey J.   +2 more
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Dynamic regulation of axon guidance [PDF]

Nature Neuroscience, 2001
To reach their proper targets, axons rely upon the actions of highly conserved families of attractive and repulsive guidance molecules, including the netrins, Slits, semaphorins and ephrins. These guidance systems are used to generate an astonishingly varied set of neuronal circuits.
Timothy W. Yu, Cornelia I. Bargmann
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Axon guidance: the cytoplasmic tail

Current Opinion in Cell Biology, 2002
Recent advances in the study of axon guidance have begun to clarify the intricate signalling mechanisms utilised by receptors that mediate path-finding. Many of these axon guidance receptors, including Plexin B, EphA, ephrin B and Robo, regulate the Rho family of GTPases, to effect changes in motility. Recent studies demonstrate a critical role for the
Bharatkumar N. Patel, David Van Vactor
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The Molecular Biology of Axon Guidance

Science, 1996
Neuronal growth cones navigate over long distances along specific pathways to find their correct targets. The mechanisms and molecules that direct this pathfinding are the topics of this review. Growth cones appear to be guided by at least four different mechanisms: contact attraction, chemoattraction, contact repulsion, and chemorepulsion. Evidence is
Corey S. Goodman, Marc Tessier-Lavigne
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Repellent cues in axon guidance

Current Opinion in Neurobiology, 1992
There is increasing evidence that axons are guided by repulsion in several regions of the developing nervous system, although this has yet to be confirmed directly in vivo. As more candidate repulsion molecules are identified, it is becoming clear that collapse of the growth cone in vitro may be mediated by more than one intracellular mechanism.
Geoffrey M.W. Cook, Roger J. Keynes
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Molecular Mechanisms of Axon Guidance

Science, 2002
Axons are guided along specific pathways by attractive and repulsive cues in the extracellular environment. Genetic and biochemical studies have led to the identification of highly conserved families of guidance molecules, including netrins, Slits, semaphorins, and ephrins.
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Wnt signaling in axon guidance

Trends in Neurosciences, 2004
Recent studies have identified Wnt proteins as conserved axon guidance molecules in vertebrates and invertebrates. Wnt proteins are a large family of diffusible factors that play several important roles, both in embryonic development and in adult function.
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Celsr3 and Fzd3 in axon guidance

The International Journal of Biochemistry & Cell Biology, 2015
The assembly of functional neuronal circuits depends on the correct wiring of axons and dendrites. To reach their targets, axons are guided by a variety of extracellular guidance cues, including Netrins, Ephrins, Semaphorins and Slits. Corresponding receptors in the growth cone, the dynamic structure at the tip of the growing axon, sense and integrate ...
Fadel Tissir, André M. Goffinet, Guoliang Chai   +2 more
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