Results 61 to 70 of about 41,175 (291)

Smart Polymeric 3D Microscaffolds Hosting Spheroids for Neuronal Research via Quantum Metrology

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
Development of a platform consisting of 3D microscaffolds supporting 3D embryoid bodies for neuronal research. The polymeric scaffolds enable directed growth of neurites. This study shows nanodiamond‐based quantum sensors graft onto the polymer material, enabling quantum metrology experiments within the 3D neuronal model and thereby providing a ...
Beatriz N. L. Costa, Ana Marote, Catarina Barbosa, Jonas Campos, António J. Salgado, Jana B. Nieder   +5 more
wiley   +1 more source

Microtubule dynamics in axon guidance [PDF]

Neuroscience Bulletin, 2014
Precise modulation of the cytoskeleton is involved in a variety of cellular processes including cell division, migration, polarity, and adhesion. In developing post-mitotic neurons, extracellular guidance cues not only trigger signaling cascades that act at a distance to indirectly regulate microtubule distribution, and assembly and disassembly in the ...
Trisha Dwyer, Guofa Liu
openaire   +3 more sources

Plexin B3 guides axons to cross the midline in vivo

Frontiers in Cellular Neuroscience
During the development of neural circuits, axons are guided by a variety of molecular cues to navigate through the brain and establish precise connections with correct partners at the right time and place. Many axon guidance cues have been identified and
Zhi-Zhi Liu, Zhi-Zhi Liu, Zhi-Zhi Liu, Zhi-Zhi Liu, Ling-Yan Liu, Ling-Yan Liu, Ling-Yan Liu, Ling-Yan Liu, Lou-Yin Zhu, Lou-Yin Zhu, Jian Zhu, Jian Zhu, Jia-Yu Luo, Jia-Yu Luo, Jia-Yu Luo, Jia-Yu Luo, Ye-Fan Wang, Ye-Fan Wang, Hong A. Xu, Hong A. Xu, Hong A. Xu, Hong A. Xu   +21 more
doaj   +1 more source

Dopaminergic axon guidance: which makes what?

Frontiers in Cellular Neuroscience, 2012
Mesotelencephalic pathways in the adult central nervous system have been studied in great detail because of their implication in major physiological functions as well as in psychiatric, neurological and neurodegenerative diseases.
Laetitia ePrestoz, Mohamed eJaber, Afsaneh eGaillard   +2 more
doaj   +1 more source

Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics

Communications Biology, 2021
Huang et al demonstrate that glioblastoma cells upregulate axon guidance molecule Plexin-B2 to gain invasiveness and that Plexin-B2 promotes glioblastoma cell infiltration along axon fiber tracts in intracranial transplant models by modulating cellular ...
Yong Huang, Rut Tejero, Vivian K. Lee, Concetta Brusco, Theodore Hannah, Taylor B. Bertucci, Chrystian Junqueira Alves, Igor Katsyv, Michael Kluge, Ramsey Foty, Bin Zhang, Caroline C. Friedel, Guohao Dai, Hongyan Zou, Roland H. Friedel   +14 more
doaj   +1 more source

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Molecular mechanisms of axon guidance

Developmental Biology, 2006
In order to form a functional nervous system, neurones extend axons, often over long distances, to reach their targets. This process is controlled by extracellular receptors and their ligands, several families of which have been identified. These proteins may act to either repel or attract growth cones and a given receptor may transduce either type of ...
openaire   +3 more sources

The Alzheimer's β-secretase enzyme BACE1 is required for accurate axon guidance of olfactory sensory neurons and normal glomerulus formation in the olfactory bulb

Molecular Neurodegeneration, 2011
Background The β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1), is a prime therapeutic target for lowering cerebral β-amyloid (Aβ) levels in Alzheimer's disease (AD).
Rajapaksha Tharinda W, Eimer William A, Bozza Thomas C, Vassar Robert   +3 more
doaj   +1 more source

3D‐Printed Scaffolds Promote Enhanced Spinal Organoid Formation for Use in Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
3D‐printed organoid scaffolds with microscale channels are developed to enhance spinal cord injury recovery by guiding region‐specific spinal neural progenitor cells. These scaffolds promote axonal growth, cell maturation, and neuronal network formation.
Guebum Han, Nicolas S. Lavoie, Nandadevi Patil, Olivia G. Korenfeld, Hyunjun Kim, Manuel Esguerra, Daeha Joung, Michael C. McAlpine, Ann M. Parr   +8 more
wiley   +1 more source

Drosophila Tet Is Expressed in Midline Glia and Is Required for Proper Axonal Development

Frontiers in Cellular Neuroscience, 2019
Ten-Eleven Translocation (TET) proteins are important epigenetic regulators that play a key role in development and are frequently deregulated in cancer.
Joy N. Ismail, Joy N. Ismail, Shireen Badini, Shireen Badini, Felice Frey, Felice Frey, Wassim Abou-Kheir, Margret Shirinian, Margret Shirinian   +8 more
doaj   +1 more source