Results 81 to 90 of about 899,641 (334)
Whole Genome Sequencing of Newly Established Pancreatic Cancer Lines Identifies Novel Somatic Mutation (c.2587G>A) in Axon Guidance Receptor Plexin A1 as Enhancer of Proliferation and Invasion. [PDF]
PLoS ONE, 2016 The genetic profile of human pancreatic cancers harbors considerable heterogeneity, which suggests a possible explanation for the pronounced inefficacy of single therapies in this disease.
Rebecca Sorber +12 more
doaj +1 more source
The WAGR syndrome gene PRRG4 is a functional homologue of the commissureless axon guidance gene
PLoS Genetics, 2017 WAGR syndrome is characterized by Wilm’s tumor, aniridia, genitourinary abnormalities and intellectual disabilities. WAGR is caused by a chromosomal deletion that includes the PAX6, WT1 and PRRG4 genes.
Elizabeth D Justice +2 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin +15 more
wiley +1 more source
Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor. [PDF]
PLoS ONE, 2014 The growth and guidance of many axons in the developing nervous system require Netrin-mediated activation of Deleted in Colorectal Cancer (DCC) and other still unknown signaling cues.
Patrick C G Haddick +8 more
doaj +1 more source
Axon Guidance: Gained in Translation [PDF]
Neuron, 2018 In this issue of Neuron, Cagnetta et al. (2018) describe a novel method to identify, in an unbiased manner, newly synthesized axonal proteins in response to axon guidance cues. They find that axons stimulated by different guidance cues (Netrin-1, BDNF, and Sema3A) show distinct and common signatures.
Frédéric Charron, Frédéric Charron
openaire +2 more sources
Advanced Materials, EarlyView.A novel one‐shot integration electropolymerization (OSIEP) method is developed as a breakthrough on the intricate photolithographic steps, enabling to compress all processes from synthesis to channel integration in one‐shot manufacturing. The specially designed dual bipolar electrodes provide the targeted depositions of poly(3,4‐ethylenedioxythiophene)
Jiyun Lee +9 more
wiley +1 more source
eLife, 2016 RNA-binding proteins (RBPs) control multiple aspects of post-transcriptional gene regulation and function during various biological processes in the nervous system.
Janelle C Leggere +5 more
semanticscholar +1 more source
Molecular mechanisms of axon guidance
Developmental Biology, 2006 In order to form a functional nervous system, neurones extend axons, often over long distances, to reach their targets. This process is controlled by extracellular receptors and their ligands, several families of which have been identified. These proteins may act to either repel or attract growth cones and a given receptor may transduce either type of ...
openaire +3 more sources
Microtubule dynamics in axon guidance [PDF]
Neuroscience Bulletin, 2014 Precise modulation of the cytoskeleton is involved in a variety of cellular processes including cell division, migration, polarity, and adhesion. In developing post-mitotic neurons, extracellular guidance cues not only trigger signaling cascades that act at a distance to indirectly regulate microtubule distribution, and assembly and disassembly in the ...
Trisha Dwyer, Guofa Liu
openaire +3 more sources
Flexible 3D Kirigami Probes for In Vitro and In Vivo Neural Applications
Advanced Materials, EarlyView.A customizable and scalable approach to fabricate flexible 3D kirigami microelectrode arrays (MEAs) featuring up to 128 shanks, including surface and penetrating electrodes designed to interact with the 3D space of neural tissue, is presented. The 3D kirigami MEAs are successfully deployed in several neural applications, both in vitro and in vivo, and ...
Marie Jung +10 more
wiley +1 more source