Results 81 to 90 of about 104,244 (349)

A requirement for filopodia extension toward Slit during Robo-mediated axon repulsion [PDF]

, 2016
Axons navigate long distances through complex 3D environments to interconnect the nervous system during development. Although the precise spatiotemporal effects of most axon guidance cues remain poorly characterized, a prevailing model posits that ...
Aaron S. Meyer, Adam V. Kwiatkowski, Akin, Bashaw, Bear, Bear, Bear, Bentley, Bray, Bray, Brose, Byun, Carlier, Cheeseman, Chen, Chien, Chédotal, Colak, Cox, Dent, Dent, Fan, Fan, Frank B. Gertler, Fricke, Gallo, Gomez, Hansen, Hansen, Hao, Hata, Hu, Hua, Hung, Hung, J. Edward van Veen, Kapfhammer, Keleman, Kidd, Kidd, Kwiatkowski, Lebrand, Long, Lowery, Lundström, Luo, Ma, Marina Vidaki, Marsick, Mattila, Mejillano, Menon, Nguyen Ba-Charvet, Niclou, Niebuhr, Peterson, Piper, Pujic, Qi, Raper, Raper, Robles, Ros, Russell E. McConnell, Shekarabi, Stein, Tang, Terman, Tosney, Vitriol, Waxman, Winkelman, Wong, Yu, Yue, Zelina   +75 more
core   +1 more source

Human disorders of axon guidance [PDF]

Current Opinion in Neurobiology, 2012
Axon pathfinding is essential for the establishment of proper neuronal connections during development. Advances in neuroimaging and genomic technologies, coupled with animal modeling, are leading to the identification of an increasing number of human disorders that result from aberrant axonal wiring.
Alicia A, Nugent, Adrianne L, Kolpak, Elizabeth C, Engle   +2 more
openaire   +2 more sources

Functional Hydrogel for Modulating Lipid Droplets and Neuroinflammation in Head Injury

Advanced Functional Materials, EarlyView.
After TBI, elevated cholesterol levels in activated microglia lead to the accumulation of cholesterol esters in lipid droplets, exacerbating neuroinflammation. A β‐cyclodextrin‐conjugated GelMA (βCD‐GelMA) hydrogel is developed to promotes cholesterol efflux and reduces LDL influx, thereby alleviating intracellular cholesterol and lipid droplet buildup.
Feixiang Chen, Yvonne Shen, Yutong Shao, Tenghuan Ge, Haowen Qiao, Shangzhou Xia, Yafei Qu, Yuanpu Chiu, Ying Qin, Zhen Zhao   +9 more
wiley   +1 more source

Loss-of-function analysis of EphA receptors in retinotectal mapping [PDF]

, 2004
Peer reviewedPublisher ...
DeChiara, Thomas M., Feldheim, David A., Flanagan, John G., Gale, Nicholas W., Nakamoto, Masaru, Osterfield, Miriam, Rohatgi, Rajat, Yancopoulos, George D.   +7 more
core   +1 more source

Bicontinuous Microarchitected Scaffolds Provide Topographic Cues That Govern Neuronal Behavior and Maturation

Advanced Functional Materials, EarlyView.
A scalable biomimetic platform transforms bioinert poly(ethylene glycol) diacrylate into neuroinstructive matrices via integrating solvent transfer‐induced phase separation, microfluidics, and 3D bioprinting. Bicontinuous, hyperbolically curved microporous networks embedded within a fibrous construct elicit rapid adhesion, robust proliferation, and ...
Prince D. Okoro, Kevin Dalsania, Shiril B. Iragavarapu, Benjamin Dela Cruz, Aihik Banerjee, Merve Basaranbilek, Martin F. Haase, Bahman Anvari, Iman Noshadi   +8 more
wiley   +1 more source

The Arp2/3 complex, UNC-115/abLIM, and UNC-34/Enabled regulate axon guidance and growth cone filopodia formation in Caenorhabditis elegans

Neural Development, 2009
Background While many molecules involved in axon guidance have been identified, the cellular and molecular mechanisms by which these molecules regulate growth cone morphology during axon outgrowth remain to be elucidated.
Lundquist Erik A, Dyer Jamie O, Norris Adam D   +2 more
doaj   +1 more source

Defining the ligand specificity of the deleted in colorectal cancer (DCC) receptor. [PDF]

PLoS ONE, 2014
The growth and guidance of many axons in the developing nervous system require Netrin-mediated activation of Deleted in Colorectal Cancer (DCC) and other still unknown signaling cues.
Patrick C G Haddick, Irene Tom, Elizabeth Luis, Gabriel Quiñones, Bernd J Wranik, Sree R Ramani, Jean-Philippe Stephan, Marc Tessier-Lavigne, Lino C Gonzalez   +8 more
doaj   +1 more source

Labyrinthine Turing Pattern Formation in the Cerebral Cortex [PDF]

, 2002
I propose that the labyrinthine patterns of the cortices of mammalian brains may be formed by a Turing instability of interacting axonal guidance species acting together with the mechanical strain imposed by the interconnecting axons.Comment: See home ...
BAIER, BARD, CARTWRIGHT, CASTETS, DICKSTEIN, DOBYNS, ERNST, FITZHUGH, FITZHUGH, GOLDSTEIN, GOODHILL, GOODWIN, GRIFFIN, HENTSCHEL, JUDD, JULYAN H.E. CARTWRIGHT, KAUFFMAN, KOCH, KONDO, MEINHARDT, MURATOV, MURRAY, MURRAY, NAGUMO, ODELL, OSTER, OUYANG, RAGHAVAN, RAKIC, RAMÓN Y CAJAL, RICHMAN, SCANNELL, SEUL, TESSIER-LAVIGNE, TODD, TURING, VAN DER POL, VAN ESSEN, WATZL, WITELSON, ZHENG, ZILLES   +41 more
core   +3 more sources

Guidance of retinal axons in mammals

Seminars in Cell & Developmental Biology, 2019
In order to navigate through the surrounding environment many mammals, including humans, primarily rely on vision. The eye, composed of the choroid, sclera, retinal pigmented epithelium, cornea, lens, iris and retina, is the structure that receives the light and converts it into electrical impulses.
Herrera E, Erskine L, Morenilla-Palao C
openaire   +4 more sources

The Synergy of Artificial Intelligence and 3D Bioprinting: Unlocking New Frontiers in Precision and Tissue Fabrication

Advanced Functional Materials, EarlyView.
Advances in integrating artificial intelligence into 3D bioprinting are systematically reviewed here. Machine learning, computer vision, robotics, natural language processing, and expert systems are examined for their roles in optimizing bioprinting parameters, real‐time monitoring, quality control, and predictive maintenance.
Joao Vitor Silva Robazzi, Irem Deniz Derman, Deepak Gupta, Logan Haugh, Yogendra Pratap Singh, Vaibhav Pal, Yasar Ozer Yilmaz, Suihong Liu, Andre Luis Dias, Rogerio Andrade Flauzino, Ibrahim Tarik Ozbolat   +10 more
wiley   +1 more source