Immunoproximity biotinylation reveals the axon initial segment proteome [PDF]
Nature Communications, 2023 The axon initial segment (AIS) is a specialized neuronal compartment required for action potential generation and neuronal polarity. However, understanding the mechanisms regulating AIS structure and function has been hindered by an incomplete knowledge ...
Wei Zhang +9 more
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Axon initial segment geometry in relation to motoneuron excitability. [PDF]
PLoS ONE, 2021 The axon initial segment (AIS) responsible for action potential initiation is a dynamic structure that varies and changes together with neuronal excitability.
Travis M Rotterman +5 more
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Investigation on constitutive IKK activity in the axon initial segment [PDF]
BMC Neuroscience, 2007 Poster presentation: The transcription factor NF-kappaB plays a central role in the development and maintenance of the central nervous system and its constitutive activation in neurons has been repeatedly reported.
König Hans-Georg +4 more
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Pyramidal cell axon initial segment in Alzheimer´s disease [PDF]
Scientific Reports, 2022 The axon initial segment (AIS) is a region of the neuron that is critical for action potential generation as well as for the regulation of neural activity.
Alejandro Antón-Fernández +3 more
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Contribution of Axon Initial Segment Structure and Channels to Brain Pathology [PDF]
Cells, 2023 Brain channelopathies are a group of neurological disorders that result from genetic mutations affecting ion channels in the brain. Ion channels are specialized proteins that play a crucial role in the electrical activity of nerve cells by controlling ...
Juan José Garrido
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Alterations in the axon initial segment plasticity is involved in early pathogenesis in Alzheimer's disease [PDF]
MedCommAlzheimer's disease (AD) is the most prevalent neurodegenerative disorder, characterized by the early presence of amyloid‐β (Aβ) and hyperphosphorylated tau.
Yu Li +11 more
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Ankyrin-G and Its Binding Partners in Neurons: Orchestrating the Molecular Structure of the Axon Initial Segment [PDF]
BiomoleculesThe axon initial segment (AIS) is a specialized subcellular domain that plays an essential role in action potential initiation and the diffusion barrier.
Xiaowei Zhu +4 more
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Actin polymerization and longitudinal actin fibers in axon initial segment plasticity [PDF]
Frontiers in Molecular NeuroscienceThe location of the axon initial segment (AIS) at the junction between the soma and axon of neurons makes it instrumental in maintaining neural polarity and as the site for action potential generation. The AIS is also capable of large-scale relocation in
David Micinski +3 more
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Impaired function of HDAC6 slows down axonal growth and interferes with axon initial segment development. [PDF]
PLoS ONE, 2010 The development of morphological neuronal polarity starts by the formation and elongation of an axon. At the same time the axon initial segment (AIS) is generated and creates a diffusion barrier which differentiate axon and somatodendritic compartment ...
Mónica Tapia +2 more
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Plasticity at the axon initial segment
Communicative & Integrative Biology, 2010 Experience dependent alterations in neural activity are mediated by diverse forms of plasticity, which are conventionally thought to occur at either synaptic terminals and/or postsynaptic membrane, such as dendrites and cell soma.
Hiroshi Kuba
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