Results 171 to 180 of about 29,685 (270)

Force stimulation promotes nerve regeneration by restoring cellular energy

BMEMat, EarlyView.
Mechanical stimulation can help nerves regenerate in various ways. We developed two devices (a piezo‐motor‐driven stretching device and a SAW‐based actuator) to apply mechanical stimulation to sciatic nerve and DRG neurons. Our study shows that appropriate mechanical force stimulation can promote regeneration by restoring the energy supply to the ...
Zhe Wang, Chen Cai, Hetao Xie, Yupeng Yang, Lei Li, Nik Ahmad Nizam Nik Malek, Wan Hairul Anuar Kamaruddin, Meiwan Chen, Yuanhua Sang, Bing Ji, Zenan Wang   +10 more
wiley   +1 more source

A distinct PP2A subunit regulates local protein phosphorylation at the axon initial segment. [PDF]

Nat Commun
Anderson AP, Kim S, Melton AJ, Ding X, Zhang W, Saltzman AB, Malovannaya A, Rasband MN, Gao Y.   +8 more
europepmc   +1 more source

Overcoming intranasal delivery barriers with ultrastable polyzwitterionic siRNA nanocages for enhanced glioblastoma therapy

BMEMat, EarlyView.
A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie, Jingxing Si, Xiaobei Deng, Jing Tan, Ruijie Zhu, Jizhou Qi, Gaoxia Ma, Bin Wang, Yi Wang, Yunzhou Guo, Yuping Chen, Shiqun Shao, Youqing Shen   +12 more
wiley   +1 more source

Evaluating TRIM46's Role in Axon Initial Segment Formation. [PDF]

J Neurosci
Belmonte S.
europepmc   +1 more source

Amyloid Precursor Protein Can Cause Changes in Neuronal Firing Rates via Axon Initial Segment. [PDF]

J Neurosci, 2023
Acharyya D, Norman V.
europepmc   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

Absence of the axon initial segment in sensory neuron enhances resistance to amyotrophic lateral sclerosis. [PDF]

Brain
Tra NT, Kiryu-Seo S, Kida H, Wakatsuki K, Tashiro Y, Tsutsumi M, Ataka M, Iguchi Y, Nemoto T, Takahashi R, Katsuno M, Kiyama H.   +11 more
europepmc   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Endoplasmic Reticulum Stress Mediates Axon Initial Segment Shortening: Implications for Diabetic Brain Complications. [PDF]

J Mol Neurosci
Shelby JN, Chisholm AM, Akhmedov I, Sheriff N, Griggs RB, Susuki K.   +5 more
europepmc   +1 more source

Donor‐To‐Recipient Mean Axonal Count Ratios of Upper Limb Nerves Used in Nerve Transfer Surgery: A Systematic Review of Histomorphometric Cadaveric Studies

Clinical Anatomy, EarlyView.
ABSTRACT Nerve transfer surgery may be performed to restore sensorimotor function following peripheral nerve trauma or dysfunction. There is biological plausibility and limited correlative evidence that donor‐to‐recipient axon count ratios may impact functional outcomes.
Samuel James Ng, Rosa Morgan‐Young, Alexander Laing, Rebecca Molden, Suzanne Thomson   +4 more
wiley   +1 more source