Results 11 to 20 of about 57,333 (280)
P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development [PDF]
Frontiers in Cellular Neuroscience, 2019 Morphological and functional polarization of neurons depends on the generation and maintenance of the axon initial segment (AIS). This axonal domain maintains axonal properties but is also the place where the action potential (AP) is generated. All these
Wei Zhang +5 more
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Inhibitory Synapse Formation at the Axon Initial Segment [PDF]
Frontiers in Molecular Neuroscience, 2019 The axon initial segment (AIS) is the site of action potential (AP) initiation in most neurons and is thus a critical site in the regulation of neuronal excitability.
Anna J. Nathanson +4 more
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Channelrhodopsin-2 localised to the axon initial segment.
PLoS ONE, 2010 The light-gated cation channel Channelrhodopsin-2 (ChR2) is a powerful and versatile tool for controlling neuronal activity. Currently available versions of ChR2 either distribute uniformly throughout the plasma membrane or are localised specifically to ...
Matthew S Grubb, Juan Burrone
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Structural and functional plasticity at the axon initial segment [PDF]
Frontiers in Cellular Neuroscience, 2016 The axon initial segment (AIS) is positioned between the axonal and somato-dendritic compartments and plays a pivotal role in triggering action potentials and determining neuronal output.
Rei Yamada, Hiroshi Kuba
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Theoretical relation between axon initial segment geometry and excitability
eLife, 2020 In most vertebrate neurons, action potentials are triggered at the distal end of the axon initial segment (AIS). Both position and length of the AIS vary across and within neuron types, with activity, development and pathology.
Sarah Goethals, Romain Brette
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Oxidative Stress Induces Disruption of the Axon Initial Segment [PDF]
ASN Neuro, 2017 The axon initial segment (AIS), the domain responsible for action potential initiation and maintenance of neuronal polarity, is targeted for disruption in a variety of central nervous system pathological insults.
Kareem C. Clark +2 more
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Sodium channel endocytosis drives axon initial segment plasticity. [PDF]
Sci Adv, 2023 Activity-dependent plasticity of the axon initial segment (AIS) endows neurons with the ability to adapt action potential output to changes in network activity. Action potential initiation at the AIS highly depends on the clustering of voltage-gated sodium channels, but the molecular mechanisms regulating their plasticity remain ...
Fréal A +7 more
europepmc +8 more sources
Extracellular Tau Oligomers Damage the Axon Initial Segment. [PDF]
J Alzheimers Dis, 2023 Background: In Alzheimer’s disease (AD) brain, neuronal polarity and synaptic connectivity are compromised. A key structure for regulating polarity and functions of neurons is the axon initial segment (AIS), which segregates somatodendritic from axonal proteins and initiates action potentials.
Best MN +13 more
europepmc +3 more sources
Axon Initial Segment–Associated Microglia [PDF]
The Journal of Neuroscience, 2015 Microglia are the brain's resident immune cells and function as the main defense against pathogens or injury. However, in the absence of disease, microglia have other functions in the normal brain. For example, previous studies showed that microglia contribute to circuit refinement and synaptic plasticity in the developing and adult brain, respectively.
Kelli, Baalman +6 more
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Neurons with Multiple Axons Have Functional Axon Initial Segments [PDF]
Neuroscience Bulletin, 2017 Neurons grow multiple axons after treatment with glycogen synthase kinase-3 (GSK-3) inhibitors. However, whether they are electrically active is not known. Here, we examined the role of multiple axons as electrophysiological components during neuronal firing. Combining pharmacological, immunofluorescence, and electrophysiological methods, we found that
Yu, Guo +5 more
openaire +2 more sources