Human Nav1.6 Channels Generate Larger Resurgent Currents than Human Nav1.1 Channels, but the Navβ4 Peptide Does Not Protect Either Isoform from Use-Dependent Reduction [PDF]
, 2015 Voltage-gated sodium channels are responsible for the initiation and propagation of action potentials (APs). Two brain isoforms, Nav1.1 and Nav1.6, have very distinct cellular and subcellular expression. Specifically, Nav1.1 is predominantly expressed in
Barbosa, Cindy +3 more
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Axon initial segments: structure, function, and disease [PDF]
Annals of the New York Academy of Sciences, 2018 AbstractThe axon initial segment (AIS) is located at the proximal axon and is the site of action potential initiation. This reflects the high density of ion channels found at the AIS. Adaptive changes to the location and length of the AIS can fine‐tune the excitability of neurons and modulate plasticity in response to activity.
Claire Yu‐Mei Huang +1 more
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The axonal cytoskeleton: from organization to function
Frontiers in Molecular Neuroscience, 2015 The axon is the single long fiber that extends from the neuron and transmits electrical signals away from the cell body. The neuronal cytoskeleton, composed of microtubules, actin filaments and neurofilaments, is not only required for axon formation and ...
Josta eKevenaar, Casper eHoogenraad
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Action potential initiation in damaged axon initial segment [PDF]
BMC Neuroscience, 2014 The effects of physical trauma to nerve cells are of great interest in neuroscience and neuromedicine. The ion channels kinetics are affected by the trauma-induced damage to neural membrane structure. The density of affected channels is at its highest in the nodes and the axon initial segment (AIS).
Jacques, Louis +3 more
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Structure and function of axo-axonic inhibition
eLife, 2021 Inhibitory neurons in mammalian cortex exhibit diverse physiological, morphological, molecular, and connectivity signatures. While considerable work has measured the average connectivity of several interneuron classes, there remains a fundamental lack of
Casey M Schneider-Mizell +39 more
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Chronic thoracic hemisection spinal cord injury in adult rats induces a progressive decline in transmission from uninjured fibers to lumbar motoneurons [PDF]
, 2008 Although most spinal cord injuries are anatomically incomplete, only limited functional recovery has been observed in people and rats with partial lesions.
Arko Ghosh +10 more
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The SNARE Protein Syntaxin 3 Confers Specificity for Polarized Axonal Trafficking in Neurons. [PDF]
, 2016 Cell polarity and precise subcellular protein localization are pivotal to neuronal function. The SNARE machinery underlies intracellular membrane fusion events, but its role in neuronal polarity and selective protein targeting remain unclear.
Albertolle, Mary E +7 more
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A Stochastic Compartmental Model for Fast Axonal Transport [PDF]
, 2011 In this paper we develop a probabilistic micro-scale compartmental model and use it to study macro-scale properties of axonal transport, the process by which intracellular cargo is moved in the axons of neurons.
McKinley, Scott A. +2 more
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In vivo assembly of the axon initial segment in motor neurons [PDF]
, 2013 International audienceThe axon initial segment (AIS) is responsible for both the modulation of action potentials and the maintenance of neuronal polarity. Yet, the molecular mechanisms controlling its assembly are incompletely understood.
A Delpy +60 more
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Cell Reports, 2019 Summary: The axon initial segment (AIS) is a compartment that serves as a molecular barrier to achieve axon-dendrite differentiation. Distribution of specific proteins during early neuronal development has been proposed to be critical for AIS ...
Sotaro Ichinose +3 more
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