A Stochastic Compartmental Model for Fast Axonal Transport [PDF]
, 2011 In this paper we develop a probabilistic micro-scale compartmental model and use it to study macro-scale properties of axonal transport, the process by which intracellular cargo is moved in the axons of neurons.
McKinley, Scott A. +2 more
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Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]
, 2010 Peer reviewedPublisher ...
Barabas, Klaudia +9 more
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Activity-Dependent Plasticity of Axo-axonic Synapses at the Axon Initial Segment [PDF]
Neuron, 2020 The activity-dependent rules that govern the wiring of GABAergic interneurons are not well understood. Chandelier cells (ChCs) are a type of GABAergic interneuron that control pyramidal cell output through axo-axonic synapses that target the axon initial segment.
Pan-Vazquez, Alejandro +4 more
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Voltage dependence of Hodgkin-Huxley rate functions for a multi-stage K channel voltage sensor within a membrane [PDF]
, 2014 The activation of a $K^+$ channel sensor in two sequential stages during a voltage clamp may be described as the translocation of a Brownian particle in an energy landscape with two large barriers between states.
Vaccaro, Samuel R.
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Cell Reports, 2020 Summary: Genetic variations in TMEM106B, coding for a lysosomal membrane protein, affect frontotemporal lobar degeneration (FTLD) in GRN- (coding for progranulin) and C9orf72-expansion carriers and might play a role in aging.
Patrick Lüningschrör +17 more
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Neural excitability increases with axonal resistance between soma and axon initial segment [PDF]
Proceedings of the National Academy of Sciences, 2020 Significance Action potentials initiate in the axon initial segment (AIS), close to the soma. Previous experimental findings suggested that a distal shift in AIS position reduces excitability, but theoretical work predicts the opposite. A distal shift in AIS position corresponds to an elevation of axial resistance
Aurélie Fékété +3 more
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Alzheimer’s Research & Therapy, 2017 Background Serotonin receptor 5-HT6 is involved in cognition and Alzheimer’s disease (AD) development. However, the mechanism of 5-HT6 in AD pathology is not clear.
Lili Hu, Bingjie Wang, Yan Zhang
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Fast sodium channel gating supports localized and efficient axonal action potential initiation [PDF]
, 2010 Action potentials (APs) are initiated in the proximal axon of most neurons. In myelinated axons, a 50-times higher sodium channel density in the initial segment compared to the soma may account for this phenomenon.
Bischofberger, Josef +1 more
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The Axon Initial Segment: An Updated Viewpoint [PDF]
The Journal of Neuroscience, 2018 At the base of axons sits a unique compartment called the axon initial segment (AIS). The AIS generates and shapes the action potential before it is propagated along the axon. Neuronal excitability thus depends crucially on the AIS composition and position, and these adapt to developmental and physiological conditions.
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Axon initial segments: diverse and dynamic neuronal compartments [PDF]
Current Opinion in Neurobiology, 2014 The axon initial segment (AIS) is a structurally and molecularly unique neuronal compartment of the proximal axon that functions as both a physiological and physical bridge between the somatodendritic and axonal domains. The AIS has two main functions: to initiate action potentials and to maintain neuronal polarity.
Takeshi, Yoshimura, Matthew N, Rasband
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