Results 271 to 280 of about 50,535 (307)
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Current Opinion in Neurobiology, 2004
Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and compensatory fibre growth in the injured adult mammalian CNS. Recent studies have shown that in vivo applications of Nogo neutralizing antibodies, peptides blocking the Nogo ...
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Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and compensatory fibre growth in the injured adult mammalian CNS. Recent studies have shown that in vivo applications of Nogo neutralizing antibodies, peptides blocking the Nogo ...
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Retrograde signaling in axonal regeneration
Experimental Neurology, 2010Neuronal regeneration in the peripheral nervous system requires mobilization of intrinsic neurite outgrowth mechanisms. This process depends on retrograde signaling between lesion site and soma to provide accurate and timely information on the nature and extent of axonal damage, and to elicit an appropriate cell body response.
Ida, Rishal, Mike, Fainzilber
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Unblocking axonal regeneration
Science-Business eXchange, 2009Harvard and Case Western scientists have identified a neuronal receptor responsible for impeding axonal regeneration following CNS injury. Next, the researchers plan to create antagonists of the receptor to block its antiregenerative effects.
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Treatment synergy in axon regeneration
Nature Neuroscience, 2016Injured mouse retinal ganglion cells, upon a combination of treatments, can regrow their axons along the entire optic pathway and re-establish connections with their correct brain targets. This can partially restore function.
Jacek, Krol, Botond, Roska
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Building bridges to regenerate axons
Science, 2016A secreted factor stimulates glia to mend spinal cord ...
Philip R, Williams, Zhigang, He
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Topological aspects of axonal regeneration
Medical Hypotheses, 2003The fibers making up any sensory system in the spinal cord come from the same cells as do the fibers in peripheral nerves yet severed nerve fibers in the adult spinal cord do not regenerate but damaged peripheral nerves - those in the extremities - do heal themselves.
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Some hypotheses concerning axon regeneration
Restorative Neurology and Neuroscience, 1990We review evidence related to several hypotheses concerning the mechanism of axon regeneration and present new data addressing one hypothesis. That one hypothesis concerns the signal that initiates changes in the cell bodies of neurons after axon damage. We identify a molecule that has a number of the properties expected of such a signal.
D L, Wilson, G W, Perry
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Rho Signaling and Axon Regeneration
2012Several major advances in our understanding of axon regeneration and functional repair in the central nervous system (CNS) together with new insights about molecular signaling pathways have led to development of viable drug candidates to treat spinal cord injury. In this review, we focus on Rho, an intracellular small GTPase that is part of a family of
L, McKerracher +2 more
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The injured axon: intrinsic mechanisms driving axonal regeneration
Trends in NeurosciencesInjury to the central nervous system (CNS) often results in permanent neurological impairments because axons fail to regenerate and re-establish lost synaptic contacts. By contrast, peripheral neurons can activate a pro-regenerative program and regenerate following a nerve lesion.
Tomé, Diogo, Almeida, Ramiro D.
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