Results 301 to 310 of about 938,041 (332)

Intrinsic heterogeneity in axon regeneration

Biochemical Society Transactions, 2022
The nervous system is composed of a variety of neurons and glial cells with different morphology and functions. In the mammalian peripheral nervous system (PNS) or the lower vertebrate central nervous system (CNS), most neurons can regenerate extensively after axotomy, while the neurons in the mammalian CNS possess only limited regenerative ability ...
Xiu-Qing Fu, Wen-Rong Zhan, Wei-Ya Tian, Dong-Dong Cao, Zhen-Ge Luo   +4 more
openaire   +2 more sources

Inflammation and axonal regeneration

Journal of Neurology, 1994
Inflammatory cells and their products contribute to neuronal survival and axonal regeneration after injury. Following sciatic nerve transection in rats, macrophages accumulate in the corresponding dorsal root ganglion, potentially supplying neurotrophic support to nerve cell bodies, and enhancing axonal regeneration.
P M, Richardson, X, Lu
openaire   +2 more sources

Inflammation and axon regeneration

Current Opinion in Neurology, 2011
The inflammatory response that accompanies neural injury involves multiple cell types and effector molecules with both positive and negative effects. Inflammation is essential for normal regeneration in the peripheral nervous system, and here we review evidence that augmenting inflammation can enhance regeneration in areas of the central nervous system
Larry I, Benowitz, Phillip G, Popovich
openaire   +2 more sources

Axon regeneration inhibitors

Neurological Research, 2008
To increase awareness of the advancements in nerve regeneration.Review of the literature regarding inhibitors of nerve outgrowth and presentation of potential agents that reverse the inhibition, thereby promoting nerve regeneration.The injured adult central nervous system (CNS) inhibits axon outgrowth, thereby limiting recovery from traumatic injury ...
Lynda J-S, Yang, Ronald L, Schnaar
openaire   +2 more sources

Axon Regeneration in the Mammalian Optic Nerve.

Annual Review of Vision Science, 2020
The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual functional defects observed after traumatic injury, in degenerative diseases such as glaucoma, or in compressive optic neuropathies such as from optic glioma.
P. Williams, L. Benowitz, J. Goldberg, Zhigang He   +3 more
semanticscholar   +1 more source

Genes in Axonal Regeneration

Molecular Neurobiology
This review explores the molecular and genetic underpinnings of axonal regeneration and functional recovery post-nerve injury, emphasizing its significance in reversing neurological deficits. It presents a systematic exploration of the roles of various genes in axonal regrowth across peripheral and central nerve injuries. Initially, it highlights genes
Wenshuang Wu, Jing Zhang, Yu Chen, Qianqian Chen, Qianyan Liu, Fuchao Zhang, Shiying Li, Xinghui Wang   +7 more
openaire   +2 more sources

Nogo and axon regeneration

Current Opinion in Neurobiology, 2004
Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and compensatory fibre growth in the injured adult mammalian CNS. Recent studies have shown that in vivo applications of Nogo neutralizing antibodies, peptides blocking the Nogo ...
openaire   +2 more sources

Retrograde signaling in axonal regeneration

Experimental Neurology, 2010
Neuronal regeneration in the peripheral nervous system requires mobilization of intrinsic neurite outgrowth mechanisms. This process depends on retrograde signaling between lesion site and soma to provide accurate and timely information on the nature and extent of axonal damage, and to elicit an appropriate cell body response.
Ida, Rishal, Mike, Fainzilber
openaire   +2 more sources

Regeneration of axons in tributary nerves

Brain Research, 1984
The present study tests 2 hypotheses: (1) that the numbers of axons that regenerate into a tributary nerve are in part dependent on the type of lesion used to transect the axons in the parent nerve; and (2) that the numbers of axons that regenerate will be different in different tributary nerves.
C B, Jenq, R E, Coggeshall
openaire   +2 more sources

Axon Regeneration in the Central Nervous System: Facing the Challenges from the Inside.

Annual Review of Cell and Developmental Biology, 2018
After an injury in the adult mammalian central nervous system (CNS), lesioned axons fail to regenerate. This failure to regenerate contrasts with axons' remarkable potential to grow during embryonic development and after an injury in the peripheral ...
Michele Curcio, F. Bradke
semanticscholar   +1 more source