Results 101 to 110 of about 271,555 (310)

Suppressing phagocyte activation by overexpressing the phosphatidylserine lipase ABHD12 preserves sarmopathic nerves

iScience
Summary: Programmed axon degeneration (AxD) is a hallmark of many neurodegenerative diseases. In healthy axons, NMNAT2 inhibits SARM1, the key executioner of AxD, to keep it from depleting NAD+ and triggering axon destruction.
Caitlin B. Dingwall, Yo Sasaki, Amy Strickland, Tong Wu, Daniel W. Summers, A. Joseph Bloom, Aaron DiAntonio, Jeffrey Milbrandt   +7 more
doaj   +1 more source

Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement

Neurobiology of Disease, 2019
Mitochondria are crucial organelles for neurophysiology and brain mitochondrial defects constitute a characteristic of Alzheimer's disease (AD). Impaired axonal mitochondrial traffic, especially the anterograde axonal mitochondrial transport is a ...
Qi Wang, Jing Tian, Hao Chen, Heng Du, Lan Guo   +4 more
doaj   +1 more source

The Lupus Damage Index Revision Program: Results From the Item Generation and Reduction Phases

Arthritis Care &Research, EarlyView.
Objective A data‐driven and expert/patient consensus‐based project to develop a revised Systemic Lupus International Collaborating Clinics (SLICC)/American College of Rheumatology (ACR) Damage Index (SDI) is under way supported by SLICC, ACR, and the Lupus Foundation of America. Our objective is to report the item generation and reduction phase results
Burak Kundakci, Megan R. W. Barber, Ann E. Clarke, Sindhu R. Johnson, Anselm Mak, Hermine I. Brunner, Murat Inanc, Rosalind Ramsey‐Goldman, Guillermo Ruiz‐Irastorza, Ellen M. Ginzler, John G. Hanly, Alexandra Legge, Cynthia Aranow, Laurent Arnaud, Nathalie Costedoat‐Chalumeau, Dafna D. Gladman, Søren Jacobsen, Michelle Petri, Clovis A. Silva, Évelyne Vinet, Alexandre E. Voskuyl, SDI Revision Literature Review Groups, SDI Revision Delphi Panel, SDI Revision Item Reduction Committee, SDI Revision Clinical Domain Groups, Ian N. Bruce   +25 more
wiley   +1 more source

DLK-dependent signaling is important for somal but not axonal degeneration of retinal ganglion cells following axonal injury

Neurobiology of Disease, 2014
Injury to retinal ganglion cell (RGC) axons triggers rapid activation of Jun N-terminal kinase (JNK) signaling, a major prodeath pathway in injured RGCs.
Kimberly A. Fernandes, Jeffrey M. Harder, Simon W. John, Peter Shrager, Richard T. Libby   +4 more
doaj   +1 more source

Disruption of axonal transport in neurodegeneration

The Journal of Clinical Investigation, 2023
Neurons are markedly compartmentalized, which makes them reliant on axonal transport to maintain their health. Axonal transport is important for anterograde delivery of newly synthesized macromolecules and organelles from the cell body to the synapse and
Sarah H. Berth, Thomas E. Lloyd
doaj   +1 more source

Thermoresponsive Soft and Self‐Anchoring Cuff Electrode for Chronic Peripheral Interfaces

Advanced Functional Materials, EarlyView.
A novel thermoresponsive, soft and self‐anchoring (TSSA) cuff electrode utilizing shape memory polymers achieves autonomous, sutureless peripheral nerve fixation. Driven by thermally induced pre‐strain and tissue adhesion, the device self‐closes and softens at body temperature, successfully minimizing mechanical mismatch. This adaptive platform ensures
Seungjun Lee, Byungwook Park, Jonghee Eun, Sohee Kim, Namsun Chou   +4 more
wiley   +1 more source

The pathophysiology of axonal transport in alzheimer’s disease

, 2014
Neurons communicate in the nervous system by carrying out information along the length of their axons to finally transmit it at the synapse. Proper function of axons and axon terminals relies on the transport of proteins, organelles, vesicles, and other ...
Opazo, Carlos M., Muñoz López, Francisco José, 1964-, Vicario Orri, Elena, 1989-, Elena Vicario-Orri, Francisco J. Muñoz, Carlos M. Opazo   +5 more
core   +1 more source

Single collateral reconstructions reveal distinct phases of corticospinal remodeling after spinal cord injury. [PDF]

, 2012
Injuries to the spinal cord often result in severe functional deficits that, in case of incomplete injuries, can be partially compensated by axonal remodeling.
Bareyre Florence M., Martin Kerschensteiner, Lang Claudia, Guo, Xiaoli, Xiaoli Guo, Guo Xiaoli, Florence M Bareyre, Lang, Claudia, Bareyre, Florence M., Claudia Lang, Kerschensteiner Martin, Kerschensteiner, Martin   +11 more
core   +2 more sources

Emerging Post‐CMOS Hardware Neurons for Brain‐Inspired Computing: Devices, Circuits, and System Integration

Advanced Functional Materials, EarlyView.
The physical realization of artificial neurons is a critical challenge for energy‐efficient neuromorphic computing. This review presents a comprehensive analysis of the evolution of artificial neuron implementations from conventional CMOS to emerging post‐CMOS technologies.
Kannan Udaya Mohanan, Hocheon Yoo, Benoît H. Lessard, Ioannis Kymissis, Chang‐Hyun Kim   +4 more
wiley   +1 more source

A translational MRI approach to validate acute axonal damage detection as an early event in multiple sclerosis

eLife
Axonal degeneration is a central pathological feature of multiple sclerosis and is closely associated with irreversible clinical disability. Current noninvasive methods to detect axonal damage in vivo are limited in their specificity and clinical ...
Antonio Cerdán Cerdá, Nicola Toschi, Constantina A Treaba, Valeria Barletta, Elena Herranz, Ambica Mehndiratta, Jose A Gomez-Sanchez, Caterina Mainero, Silvia De Santis   +8 more
doaj   +1 more source