Results 91 to 100 of about 271,555 (310)

ATF3 upregulation in glia during Wallerian degeneration: differential expression in peripheral nerves and CNS white matter [PDF]

, 2004
Background: Many changes in gene expression occur in distal stumps of injured nerves but the transcriptional control of these events is poorly understood.
Coffin, RS, Hossain-Ibrahim Kismet, Mason, MRJ, Lieberman AR, Lieberman, AR, Mason Matthew RJ, Hossain-Ibrahim, K, David Hunt, Winterbottom, J, Anderson, PN, Hunt David, AR Lieberman, Kismet Hossain-Ibrahim, Anderson PN, Coffin Robert S, Hunt, D, PN Anderson, Matthew RJ Mason, Robert S Coffin, Winterbottom Julia, Julia Winterbottom   +20 more
core   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Fabio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Identification of genes differentially expressed in rat brain during postnatal development [PDF]

, 2003
During neuronal development CNS neurons extend axons over long distances. This high growth potential is lost during postnatal development resulting in very poor axonal outgrowth and regeneration in the adult CNS. This pronounced decline of axon growth
Hofsäss, Ulrike
core   +1 more source

Collapsin response mediator protein-2 plays a major protective role in acute axonal degeneration

Neural Regeneration Research, 2017
Axonal degeneration is a key pathological feature in many neurological diseases. It often leads to persistent deficits due to the inability of axons to regenerate in the central nervous system.
Jian-Nan Zhang, Jan C Koch
doaj   +1 more source

White Matter and Perivascular Imaging Changes in Alzheimer's Disease and Cerebral Amyloid Angiopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Peak‐width of skeletonized mean diffusivity (PSMD) and diffusion tensor imaging–analysis along the perivascular space (DTI‐ALPS), reflecting white matter integrity and glymphatic function, are altered in Alzheimer's disease (AD).
Debina Laishram, Guangwei Du, Sangam Kanekar, Nandakumar Nagaraja   +3 more
wiley   +1 more source

Treatment response in relation to inflammatory and axonal surrogate marker in multiple sclerosis [PDF]

, 2004
BACKGROUND: This study aimed to investigate if treatment response could retrospectively be related to inflammatory or axonal pathology as measured by plasma surrogate markers.
Petzold, A., Thompson, E.J., Brassat, D., Keir, G., Clanet, M., Rejdak, K., Giovannoni, G., Mas, P.   +7 more
core  

Chronic Inflammatory or Chronic Inflammatory Demyelinating Polyradiculoneuropathy?

Frontiers in Neurology, 2022
Jean-Michel Vallat, Nathalie Deschamps, Philippe Corcia, Laurent Magy, Stéphane Mathis   +4 more
doaj   +1 more source

Neurological, Neurodevelopmental and Treatment Outcomes in Patients With Pyruvate Dehydrogenase Complex Deficiency

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of this study was to characterize intellectual and motor function, neurological features including epilepsy, treatment response, and adaptive behavior in patients with pyruvate dehydrogenase complex deficiency (PDCD) in Sweden.
Antri Savvidou, Colin Reilly, Kalliopi Sofou, Sofia Ygberg, Erik A. Eklund, Karin Naess, Niklas Darin   +6 more
wiley   +1 more source

Axonal projections of Renshaw cells in the thoracic spinal cord [PDF]

, 2013
Renshaw cells are widely distributed in all segments of the spinal cord, but detailed morphological studies of these cells and their axonal branching patterns have only been made for lumbosacral segments.
Ford, TW, Saywell, SA, Kirkwood, PA
core  

White matter damage and cognitive impairment after traumatic brain injury [PDF]

, 2010
White matter disruption is an important determinant of cognitive impairment after brain injury, but conventional neuroimaging underestimates its extent.
Powell, Jane Hilary, Leech, R, K. M. Kinnunen, Counsell, Serena Jane; id_orcid, Bonnelle, V., Bonnelle, V, Sharp, D. J., Kinnunen, K. M., Hawkins, Peter Charlie; id_orcid, Patel, Maneesh Chandrakant, Patel, MC, M. C. Patel, Sharp, David James, Greenwood, Richard, D. J. Sharp, Hawkins, PC, Leech, R., Patel, M. C., Powell, Jane H., Greenwood, R, J. H. Powell, Counsell, S. J., Sharp, DJ, P. C. Hawkins, Counsell, SJ, Powell, JH, R. Greenwood, Kinnunen, KM, R. Leech, Bonnelle, Valerie, Leech, Robert, V. Bonnelle, Kinnunen, Kirsi Maria, Hawkins, R. C., S. J. Counsell   +34 more
core   +1 more source