Results 71 to 80 of about 271,555 (310)

Layer 5 myelination gates corticothalamic coincidence detection

Nature Communications
Myelin is essential for the rapid conduction of action potentials (APs) but its role in long-range processing of disparate inputs remains unclear. Here, using a cell-type-specific approach we recorded optogenetically evoked pyramidal neuron responses via
Nora Jamann, Jorrit S. Montijn, Naomi Petersen, Roeland Lokhorst, Daan van den Burg, Maayke Balemans, Stan L. W. Driessens, J. Alexander Heimel, Maarten H. P. Kole   +8 more
doaj   +1 more source

Electrodiagnostic evaluation in diabetes mellitus: A study based on case series in 72 diabetic patients

Journal of Family Medicine and Primary Care
Diabetic peripheral neuropathy (DPN) is one of the most common complications of diabetes; so, a nerve conduction study (NCS) is conducted to detect the type of neuropathy that is present. To discuss the NCS findings in diabetic patients. An observational
Suchitra Dube, Sandip M. Hulke, Avinash E. Thakare, Sagar Khadanga, Santosh L. Wakode, Rajay N. Bharshankar, Abhijit Pakhare   +6 more
doaj   +1 more source

Characterizing brain structures and remodeling after TBI based on information content, diffusion entropy. [PDF]

PLoS ONE, 2013
To overcome the limitations of conventional diffusion tensor magnetic resonance imaging resulting from the assumption of a Gaussian diffusion model for characterizing voxels containing multiple axonal orientations, Shannon's entropy was employed to ...
Niloufar Fozouni, Michael Chopp, Siamak P Nejad-Davarani, Zheng Gang Zhang, Norman L Lehman, Steven Gu, Yuji Ueno, Mei Lu, Guangliang Ding, Lian Li, Jiani Hu, Hassan Bagher-Ebadian, David Hearshen, Quan Jiang   +13 more
doaj   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

The Genetics of Axonal Transport and Axonal Transport Disorders

PLoS Genetics, 2006
Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal. The organized transport of essential biological materials throughout the neuron is required to support its growth, function, and viability.
Jason E Duncan, Lawrence S B Goldstein
openaire   +4 more sources

Computational Analysis of the Effects of Antineoplastic Agents on Axonal Transport

Journal of Pharmacological Sciences, 2010
Axonal transport plays a crucial role in neuronal morphogenesis, survival, and function. Despite its importance, however, the molecular mechanisms of axonal transport remain mostly unknown because a simple and quantitative assay system for axonal ...
Yoshio Goshima, Hiroshi Usui, Takahito Shiozawa, Tomonobu Hida, Satoshi Kuraoka, Sayumi Takeshita, Naoya Yamashita, Yasushi Ichikawa, Yoshinori Kamiya, Takahisa Gotoh, Toshiyuki Gotoh   +10 more
doaj   +1 more source

T1 Over Squared Proton Density Ratio to Characterize Multiple Sclerosis Lesions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Differentiating remyelinated from demyelinated lesions in MS remains challenging without histological confirmation. This study introduces the T1‐to‐PD2 ratio (TPR) imaging approach and evaluates its ability to characterize MS lesions alongside other quantitative MRI (qMRI) metrics. Methods Thirty individuals with MS (mean age: 47.5 ± 
Sarah J. Wright, Scotty G. McKay, Jean Ramos Bou, Fen Bao, Vivian B. Truong, Chenyang Li, Li Jiang, Anza B. Memon, E. Mark Haacke, Yulin Ge, Yongsheng Chen   +10 more
wiley   +1 more source

Role of Nerve Ultrasound in the Assessment of Peripheral Neuropathy

Medical Journal of Babylon
Background: Peripheral neuropathy (PN) is a group of disorders that affects peripheral nerves with variable pathologic and etiologic mechanisms. Objective: The aims of this research are to find the role of assessing nerve cross-sectional area (CSA) and ...
Bashaer H. Obayes, Zahraa A. Al-Mudhafar, Zahid Mohammad Kadhim, Qebas H. Alsultani   +3 more
doaj   +1 more source

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

The new Global Multiple Sclerosis Severity Score (MSSS) correlates with axonal but not glial biomarkers [PDF]

, 2006
This study investigated whether the new Global Multiple Sclerosis Severity Scale (MSSS) correlated with cerebrospinal fluid biomarkers for axonal and glial pathology.
Polman, C.H., Uitdehaag, B.M.J., Eikelenboom, M.J., Petzold, A., Thompson, E.J., Keir, G., Giovannoni, G.   +6 more
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