Results 71 to 80 of about 1,099,148 (284)

Modeling Progressive Brain Volume Losses in Chronic Moderate Severe Traumatic Brain Injury: Extensive, but Attenuating

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Progressive brain atrophy has now been widely observed in the chronic stages of moderate–severe traumatic brain injury (msTBI), but there is only coarse information regarding its prevalence and magnitude, and whether rate of atrophy accelerates or attenuates across time. We examined these questions in a Canadian inception cohort from
Robin E. A. Green, Brenda Colella, Alana Changoor, David J. Mikulis, Adrienne Li, Kadeen Johns, Georges A. Monette   +6 more
wiley   +1 more source

RNA sequence reveals mouse retinal transcriptome changes early after axonal injury.

PLoS ONE, 2014
Glaucoma is an ocular disease characterized by progressive retinal ganglion cell (RGC) death caused by axonal injury. However, the underlying mechanisms involved in RGC death remain unclear.
Masayuki Yasuda, Yuji Tanaka, Morin Ryu, Satoru Tsuda, Toru Nakazawa   +4 more
doaj   +1 more source

Diffusion Basis Spectrum Imaging of Tissue Microstructure and Early Treatment in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Conventional MRI cannot resolve the coexisting pathological processes within multiple sclerosis tissue. Diffusion Basis Spectrum Imaging decomposes the diffusion signal into fiber, cell, and hindered ratios indexing axonal integrity, cellularity, and extracellular space, respectively.
Apisit Kaewsanit, Aime Luna, Bradley Judge, Nicole Shelley, Karl Friedrichsen, Jayashree Rajamanickam, Zhude Tu, Yong Wang, Tammie L. S. Benzinger, Qing Wang, Matthew R. Brier   +10 more
wiley   +1 more source

Micromechanics of diffuse axonal injury: influence of axonal orientation and anisotropy [PDF]

Biomechanics and Modeling in Mechanobiology, 2010
Multiple length scales are involved in the development of traumatic brain injury, where the global mechanics of the head level are responsible for local physiological impairment of brain cells. In this study, a relation between the mechanical state at the tissue level and the cellular level is established.
Cloots, R.J.H., Dommelen, van, J.A.W., Nyberg, T., Kleiven, S., Geers, M.G.D.   +4 more
openaire   +2 more sources

The role of growth associated transcription factors c-Jun and ATMIN in neuronal regeneration and repair [PDF]

, 2010
Subsequent to neuronal injury, increased levels of protein synthesis accompany associated rises in transcription factor expression. Two transcription factors involved in the cellular stress response are c-Jun and ATMIN. Neuron-specific deletion of c-Jun
Ruff, C.A.D.B.
core  

Single collateral reconstructions reveal distinct phases of corticospinal remodeling after spinal cord injury. [PDF]

, 2012
Injuries to the spinal cord often result in severe functional deficits that, in case of incomplete injuries, can be partially compensated by axonal remodeling.
Bareyre Florence M., Martin Kerschensteiner, Lang Claudia, Guo, Xiaoli, Xiaoli Guo, Guo Xiaoli, Florence M Bareyre, Lang, Claudia, Bareyre, Florence M., Claudia Lang, Kerschensteiner Martin, Kerschensteiner, Martin   +11 more
core   +2 more sources

Detecting axonal injury in individual patients after traumatic brain injury. [PDF]

, 2020
Poor outcomes after traumatic brain injury (TBI) are common yet remain difficult to predict. Diffuse axonal injury is important for outcomes, but its assessment remains limited in the clinical setting.
Graham, Neil SN, Sharp, David J, Zimmerman, Karl, Balaet, Maria, Jolly, Amy E, Sandrone, Stefano, Friedland, Daniel, Azor, Adriana, Amy E Jolly, Daniel Friedland, Stefano Sandrone, Maria Bălăeţ, Karl Zimmerman, David J Sharp, Adriana Azor, Neil S N Graham   +15 more
core   +1 more source

Investigation of Complement Activation and Cytokine Signatures in AQP4+ NMOSD, MOGAD, and MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Aquaporin‐4‐IgG seropositive neuromyelitis optica spectrum disorder (AQP4+ NMOSD), myelin oligodendrocyte glycoprotein antibody‐associated disease (MOGAD), and multiple sclerosis (MS) are pathophysiologically distinct neuroinflammatory disorders. Complement activation is a major mechanism of injury in AQP4+ NMOSD, whereas its role in
Angeliki G. Filippatou, Susana Dominguez‐Penuela, David Acero‐Garces, Georgios Gakis, Matthew D. Smith, Yasmin Resto, Maria Reyes‐Mantilla, Haiwen Chen, Isabella Hernandez, Yana Said, Andrea Salazar‐Camelo, Christina Huynh, Alessia Tassoni, Ted Yednock, Rick Artis, Yaisa Andrews‐Zwilling, Scott D. Newsome, Shiv Saidha, Pavan Bhargava, Ellen M. Mowry, Kathryn C. Fitzgerald, Peter A. Calabresi, Carlos A. Pardo, Elias S. Sotirchos   +23 more
wiley   +1 more source

Development of a paediatric model of diffuse traumatic brain injury in ferrets

Scientific Reports
Traumatic brain injury (TBI) is a leading cause of death and disability in children, especially those under five, with younger children more vulnerable to persistent cognitive and neuropsychological effects due to disrupted brain development.
Justin L. Krieg, Carl Hooper, Hasini Kapuwelle, Rebecca P. George, Rebecca J. Hood, William T. O’Brien, Stuart J. McDonald, Anna V. Leonard, Renée J. Turner, Frances Corrigan   +9 more
doaj   +1 more source

Juvenile Huntington Disease With Cerebellar‐Predominant Atrophy Identified by Genome Sequencing

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Juvenile Huntington disease accounts for a small fraction of Huntington disease cases and is driven by the largest trinucleotide repeat expansions. We describe a 6‐year‐old boy with progressive global regression, generalized dystonia, and epilepsy, in whom serial imaging showed striking cerebellar‐predominant atrophy with an initially normal ...
Enrique Gonzalez Saez‐Diez, Amy Tam, Siofra Carty, Monica Ferrer Socorro, Kathryn Yang, Darius Ebrahimi‐Fakhari   +5 more
wiley   +1 more source