Disruption of axonal transport in neurodegeneration [PDF]
The Journal of Clinical Investigation, 2023 Neurons are markedly compartmentalized, which makes them reliant on axonal transport to maintain their health. Axonal transport is important for anterograde delivery of newly synthesized macromolecules and organelles from the cell body to the synapse and
Sarah H. Berth, Thomas E. Lloyd
doaj +4 more sources
Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse. [PDF]
PLoS ONE, 2012 Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport.
Chi Wang Ip +10 more
doaj +12 more sources
The genetics of axonal transport and axonal transport disorders. [PDF]
PLoS Genetics, 2006 Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal.
Jason E Duncan, Lawrence S B Goldstein
doaj +5 more sources
A high affinity RIM-binding protein/Aplip1 interaction prevents the formation of ectopic axonal active zones [PDF]
eLife, 2015 Synaptic vesicles (SVs) fuse at active zones (AZs) covered by a protein scaffold, at Drosophila synapses comprised of ELKS family member Bruchpilot (BRP) and RIM-binding protein (RBP).
Matthias Siebert +19 more
doaj +4 more sources
Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research? [PDF]
Neurobiology of Disease, 2017 Intracellular trafficking of cargoes is an essential process to maintain the structure and function of all mammalian cell types, but especially of neurons because of their extreme axon/dendrite polarisation.
Kurt J. De Vos, Majid Hafezparast
doaj +3 more sources
Common mechanisms underlying axonal transport deficits in neurodegenerative diseases: a mini review [PDF]
Frontiers in Molecular Neuroscience, 2023 Many neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the accumulation of pathogenic proteins and abnormal localization of organelles. These pathological features may be
Xiaoman Yang +4 more
doaj +2 more sources
Disruption of axonal transport in Parkinson’s disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling [PDF]
npj Parkinson's DiseaseThe accumulation of α-synuclein within Lewy bodies is a critical factor in the pathogenesis of Parkinson’s disease, with potential implications for axonal transport deficits.
Xiaoman Yang +8 more
doaj +2 more sources
NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport [PDF]
Molecular NeurodegenerationBackground Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide mononucleotide ...
Sen Yang +11 more
doaj +2 more sources
Research progress on the relationship between axonal transport dysfunction in neuronal cells and Alzheimer’s disease [PDF]
Xin yixue, 2022 Alzheimer’s disease is known as one of the “top ten killers in the world”. Due to lack of effective therapy at present， early pathological changes have captivated widespread attention.
Yu Minghui, Xue Ao, Xu Hongdan, Wang Yan, Lin Xue, Yang Bo, Sun Huifeng, Zhang Ning
doaj +1 more source
HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neurons. [PDF]
PLoS ONE, 2012 Even though the disruption of axonal transport is an important pathophysiological factor in neurodegenerative diseases including Alzheimer's disease (AD), the relationship between disruption of axonal transport and pathogenesis of AD is poorly understood.
Chaeyoung Kim +6 more
doaj +1 more source