The genetics of axonal transport and axonal transport disorders. [PDF]
PLoS Genetics, 2006 Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal.
Jason E Duncan, Lawrence S B Goldstein
doaj +4 more sources
Disruption of axonal transport in neurodegeneration [PDF]
The Journal of Clinical Investigation, 2023 Neurons are markedly compartmentalized, which makes them reliant on axonal transport to maintain their health. Axonal transport is important for anterograde delivery of newly synthesized macromolecules and organelles from the cell body to the synapse and
Sarah H. Berth, Thomas E. Lloyd
doaj +2 more sources
Axonal transport during injury on a theoretical axon. [PDF]
Front Cell Neurosci, 2023 Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles. Axonopathies are caused by brain trauma and genetic diseases that perturb or disrupt the axon MT infrastructure and, with it, the dynamic interplay of motor ...
Chandra S +4 more
europepmc +4 more sources
Influence of palmitoylation in axonal transport mechanisms in neurodegenerative diseases [PDF]
Frontiers in Cellular NeuroscienceProgressive functional loss and death of neurons are characteristics of neurodegenerative diseases such as Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD).
Praveen B. S., Priti Talwar
doaj +2 more sources
Common mechanisms underlying axonal transport deficits in neurodegenerative diseases: a mini review [PDF]
Frontiers in Molecular Neuroscience, 2023 Many neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis are characterized by the accumulation of pathogenic proteins and abnormal localization of organelles. These pathological features may be
Xiaoman Yang +4 more
doaj +2 more sources
Disruption of axonal transport in Parkinson’s disease: the role of pathological α-Syn and AMPK/p38 MAPK signaling [PDF]
npj Parkinson's DiseaseThe accumulation of α-synuclein within Lewy bodies is a critical factor in the pathogenesis of Parkinson’s disease, with potential implications for axonal transport deficits.
Xiaoman Yang +8 more
doaj +2 more sources
NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport [PDF]
Molecular NeurodegenerationBackground Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide mononucleotide ...
Sen Yang +11 more
doaj +2 more sources
Impaired axonal transport contributes to neurodegeneration in a Cre-inducible mouse model of myocilin-associated glaucoma [PDF]
JCI InsightElevation of intraocular pressure (IOP) due to trabecular meshwork (TM) dysfunction, leading to neurodegeneration, is the pathological hallmark of primary open-angle glaucoma (POAG).
Balasankara Reddy Kaipa +10 more
doaj +2 more sources
Research progress on the relationship between axonal transport dysfunction in neuronal cells and Alzheimer’s disease [PDF]
Xin yixue, 2022 Alzheimer’s disease is known as one of the “top ten killers in the world”. Due to lack of effective therapy at present， early pathological changes have captivated widespread attention.
Yu Minghui, Xue Ao, Xu Hongdan, Wang Yan, Lin Xue, Yang Bo, Sun Huifeng, Zhang Ning
doaj +1 more source
Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death. [PDF]
Mol MedMartínez P +7 more
europepmc +3 more sources