Disruption of axonal transport in neurodegeneration [PDF]
The Journal of Clinical Investigation, 2023 Neurons are markedly compartmentalized, which makes them reliant on axonal transport to maintain their health. Axonal transport is important for anterograde delivery of newly synthesized macromolecules and organelles from the cell body to the synapse and
Sarah H. Berth, Thomas E. Lloyd
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Anterograde Axonal Transport in Neuronal Homeostasis and Disease
Frontiers in Molecular Neuroscience, 2020 Neurons are highly polarized cells with an elongated axon that extends far away from the cell body. To maintain their homeostasis, neurons rely extensively on axonal transport of membranous organelles and other molecular complexes.
Laurent Guillaud +3 more
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The genetics of axonal transport and axonal transport disorders. [PDF]
PLoS Genetics, 2006 Neurons are specialized cells with a complex architecture that includes elaborate dendritic branches and a long, narrow axon that extends from the cell body to the synaptic terminal.
Jason E Duncan, Lawrence S B Goldstein
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Disease-associated mutations hyperactivate KIF1A motility and anterograde axonal transport of synaptic vesicle precursors [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance Anterograde axonal transport supplies organelles and protein complexes throughout axonal processes to support neuronal morphology and function.
Kyoko Chiba +8 more
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The Role of Axonal Transport in Glaucoma. [PDF]
Int J Mol Sci, 2022 Glaucoma is a neurodegenerative disease that affects the retinal ganglion cells (RGCs) and leads to progressive vision loss. The first pathological signs can be seen at the optic nerve head (ONH), the structure where RGC axons leave the retina to compose
Dias MS +4 more
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Oligodendrocytes support axonal transport and maintenance via exosome secretion.
PLoS Biology, 2020 Neurons extend long axons that require maintenance and are susceptible to degeneration. Long-term integrity of axons depends on intrinsic mechanisms including axonal transport and extrinsic support from adjacent glial cells.
Carsten Frühbeis +10 more
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Genetic evidence for a functional association between Parkinson’s disease proteins leucine-rich repeat kinase 2 and α-synuclein during axonal transport [PDF]
Frontiers in Molecular NeuroscienceMutations in α-synuclein (α-syn) and LRRK2 cause familial Parkinson’s disease (fPD), yet how these proteins functionally interact remain ambiguous.
Piyali Chakraborty +5 more
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bioRxiv, 2021 The dependence of neurons on microtubule-based motors for the movement of lysosomes over long distances raises questions about adaptations that allow neurons to meet these demands.
Swetha Gowrishankar +5 more
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Axonal transport during injury on a theoretical axon. [PDF]
Front Cell Neurosci, 2023 Neurodevelopment, plasticity, and cognition are integral with functional directional transport in neuronal axons that occurs along a unique network of discontinuous polar microtubule (MT) bundles. Axonopathies are caused by brain trauma and genetic diseases that perturb or disrupt the axon MT infrastructure and, with it, the dynamic interplay of motor ...
Chandra S +4 more
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Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons. [PDF]
PLoS Pathogens, 2018 Neuroinvasive viruses, such as alpha herpesviruses (αHV) and rabies virus (RABV), initially infect peripheral tissues, followed by invasion of the innervating axon termini.
Margaret A MacGibeny +4 more
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