HDAC6 inhibitor blocks amyloid beta-induced impairment of mitochondrial transport in hippocampal neurons. [PDF]
PLoS ONE, 2012 Even though the disruption of axonal transport is an important pathophysiological factor in neurodegenerative diseases including Alzheimer's disease (AD), the relationship between disruption of axonal transport and pathogenesis of AD is poorly understood.
Chaeyoung Kim +6 more
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Anterograde Axonal Transport in Neuronal Homeostasis and Disease
Frontiers in Molecular Neuroscience, 2020 Neurons are highly polarized cells with an elongated axon that extends far away from the cell body. To maintain their homeostasis, neurons rely extensively on axonal transport of membranous organelles and other molecular complexes.
Laurent Guillaud +3 more
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A high mitochondrial transport rate characterizes CNS neurons with high axonal regeneration capacity. [PDF]
PLoS ONE, 2017 Improving axonal transport in the injured and diseased central nervous system has been proposed as a promising strategy to improve neuronal repair. However, the contribution of each cargo to the repair mechanism is unknown.
Romain Cartoni +4 more
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Oxidative stress inhibits axonal transport: implications for neurodegenerative diseases
Molecular Neurodegeneration, 2012 Background Reactive oxygen species (ROS) released by microglia and other inflammatory cells can cause axonal degeneration. A reduction in axonal transport has also been implicated as a cause of axonal dystrophies and neurodegeneration, but there is a ...
Fang Cheng +2 more
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Computational Analysis of the Effects of Antineoplastic Agents on Axonal Transport
Journal of Pharmacological Sciences, 2010 Axonal transport plays a crucial role in neuronal morphogenesis, survival, and function. Despite its importance, however, the molecular mechanisms of axonal transport remain mostly unknown because a simple and quantitative assay system for axonal ...
Yoshio Goshima +10 more
doaj +1 more source
Ex Vivo Recording of Axonal Transport Dynamics on Postnatal Organotypic Cortical Slices
STAR Protocols, 2020 Summary: Axonal transport is a physiological process adopted by neurons to transport organelles, proteins, and other molecules along their axonal projections.
Silvia Turchetto +2 more
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Retrograde axonal transport of rabies virus is unaffected by interferon treatment but blocked by emetine locally in axons. [PDF]
PLoS Pathogens, 2018 Neuroinvasive viruses, such as alpha herpesviruses (αHV) and rabies virus (RABV), initially infect peripheral tissues, followed by invasion of the innervating axon termini.
Margaret A MacGibeny +4 more
doaj +1 more source
Neurobiology of Disease, 2015 Parkinson's disease (PD) is mainly attributed to degeneration of dopamine neurons in the substantia nigra, but its etiopathogenesis also includes impaired protein clearance and axonal transport dysfunction, among others. The spread of α-synuclein (α-syn)
Jennifer T. Lamberts +2 more
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Rab2 drives axonal transport of dense core vesicles and lysosomal organelles
Cell Reports, 2021 Summary: Fast axonal transport of neuropeptide-containing dense core vesicles (DCVs), endolysosomal organelles, and presynaptic components is critical for maintaining neuronal functionality.
Viktor Karlovich Lund +5 more
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PLoS ONE, 2012 Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport.
Chi Wang Ip +10 more
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