Results 21 to 30 of about 68,755 (290)
Axonal transport plays a crucial role in mediating the axon-protective effects of NmNAT
Neurobiology of Disease, 2014 Deficits in axonal transport are thought to contribute to the pathology of many neurodegenerative diseases. Expressing the slow Wallerian degeneration protein (WldS) or related nicotinamide mononucleotide adenyltransferases (NmNATs) protects axons ...
Cheng Fang, Helena Decker, Gary Banker
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Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer's neurons. [PDF]
PLoS ONE, 2013 Normal axonal mitochondrial transport and function is essential for the maintenance of synaptic function. Abnormal mitochondrial motility and mitochondrial dysfunction within axons are critical for amyloid β (Aβ)-induced synaptic stress and the loss of ...
Lan Guo +6 more
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CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon.
PLoS Genetics, 2021 Neurons are highly specialized cells with polarized cellular processes and subcellular domains. As vital organelles for neuronal functions, mitochondria are distributed by microtubule-based transport systems.
Ying-Chun Chen +3 more
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Neurobiology of Disease, 2017 Many neurodegenerative diseases are characterized by deficiencies in neuronal axonal transport, a process in which cellular cargo is shuttled with the aid of molecular motors from the cell body to axonal termini and back along microtubules (MTs).
Kurt R. Brunden +4 more
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Impaired axonal transport in motor neurons correlates with clinical prion disease. [PDF]
PLoS Pathogens, 2009 Prion diseases are fatal neurodegenerative disorders causing motor dysfunctions, dementia and neuropathological changes such as spongiosis, astroglyosis and neuronal loss. The chain of events leading to the clinical disease and the role of distinct brain
Vladimir Ermolayev +7 more
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Amyloid beta-mediated KIF5A deficiency disrupts anterograde axonal mitochondrial movement
Neurobiology of Disease, 2019 Mitochondria are crucial organelles for neurophysiology and brain mitochondrial defects constitute a characteristic of Alzheimer's disease (AD). Impaired axonal mitochondrial traffic, especially the anterograde axonal mitochondrial transport is a ...
Qi Wang +4 more
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Profiling Axonal mRNA Transport [PDF]
, 2011 The importance of mRNA localization and localized protein synthesis to spatially modulate protein levels in distinct subcellular domains has increasingly been recognized in recent years. Axonal and dendritic processes of neurons represent separate functional domains of the cell that have shown the capacity to autonomously respond to extracellular ...
Dianna E, Willis, Jeffery L, Twiss
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Acta Neuropathologica Communications, 2019 Damage to axonal transport is an early pathogenic event in Alzheimer’s disease. The amyloid precursor protein (APP) is a key axonal transport cargo since disruption to APP transport promotes amyloidogenic processing of APP.
Gábor M. Mórotz +9 more
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Frontiers in Molecular Neuroscience, 2022 Mitochondria are essential organelle required for neuronal homeostasis. Mitochondria supply ATP and buffer calcium at synaptic terminals. However, the complex structural geometry of neurons poses a unique challenge in transporting mitochondria to ...
Anusruti Sabui +6 more
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A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport
Cell Reports, 2019 Summary: Dysregulated axonal trafficking of mitochondria is linked to neurodegenerative disorders. We report a high-content screen for small-molecule regulators of the axonal transport of mitochondria.
Evgeny Shlevkov +15 more
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