Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects [PDF]
, 2009 Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17
Falzone, Tomas Luis +6 more
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Defective axonal transport in motor neuron disease [PDF]
, 2007 Several recent studies have highlighted the role of axonal transport in the pathogenesis of motor neuron diseases. Mutations in genes that control microtubule regulation and dynamics have been shown to cause motor neuron degeneration in mice and in a ...
Baas +77 more
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Cyclophilin D deficiency rescues axonal mitochondrial transport in Alzheimer's neurons. [PDF]
PLoS ONE, 2013 Normal axonal mitochondrial transport and function is essential for the maintenance of synaptic function. Abnormal mitochondrial motility and mitochondrial dysfunction within axons are critical for amyloid β (Aβ)-induced synaptic stress and the loss of ...
Lan Guo +6 more
doaj +1 more source
The time course of ongoing activity during neuritis and following axonal transport disruption [PDF]
, 2018 Local nerve inflammation (neuritis) leads to ongoing activity and axonal mechanical sensitivity (AMS) along intact nociceptor axons, and disrupts axonal transport. This phenomenon forms the most feasible cause of radiating pain, such as sciatica.
Bove, Geoffrey M +3 more
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Regulation of Axonal Transport by Protein Kinases [PDF]
, 2015 The intracellular transport of organelles, proteins, lipids, and RNA along the axon is essential for neuronal function and survival. This process, called axonal transport, is mediated by two classes of ATP-dependent motors, kinesins, and cytoplasmic ...
Gibbs, KL, Greensmith, L, Schiavo, G
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A role for kinesin heavy chain in controlling vesicle transport into dendrites in Drosophila. [PDF]
, 2011 The unique architecture of neurons requires the establishment and maintenance of polarity, which relies in part on microtubule-based transport to deliver essential cargo into dendrites.
Goldstein, Lawrence SB +3 more
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One at a time, live tracking of NGF axonal transport using quantum dots [PDF]
, 2007 Retrograde axonal transport of nerve growth factor (NGF) signals is critical for the survival, differentiation, and maintenance of peripheral sympathetic and sensory neurons and basal forebrain cholinergic neurons.
A. Ramirez +45 more
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Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels [PDF]
, 2017 Defective axonal transport is an early neuropathological feature of amyotrophic lateral sclerosis (ALS). We have previously shown that ALS-associated mutations in Cu/Zn superoxide dismutase 1 (SOD1) impair axonal transport of mitochondria in motor ...
Bauer, C.S. +4 more
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CRMP/UNC-33 organizes microtubule bundles for KIF5-mediated mitochondrial distribution to axon.
PLoS Genetics, 2021 Neurons are highly specialized cells with polarized cellular processes and subcellular domains. As vital organelles for neuronal functions, mitochondria are distributed by microtubule-based transport systems.
Ying-Chun Chen +3 more
doaj +1 more source
A Stochastic Compartmental Model for Fast Axonal Transport [PDF]
, 2011 In this paper we develop a probabilistic micro-scale compartmental model and use it to study macro-scale properties of axonal transport, the process by which intracellular cargo is moved in the axons of neurons.
McKinley, Scott A. +2 more
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