Results 261 to 270 of about 436,100 (389)

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

open access: yesAdvanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu   +17 more
wiley   +1 more source

The pH Dependency of Relative Ion Permeabilities in the Crayfish Giant Axon

open access: bronze, 1969
Alfred Strickholm   +2 more
openalex   +1 more source

Weak and Tunable Adhesion–Clutch Drives Rapid Cell Migration and Glioblastoma Invasion

open access: yesAdvanced Science, EarlyView.
This study proposes that adhesion–clutch can mediate both cell motility and immobilization depending on the force amplitude. Weak adhesion–clutch is well‐suited for cell migration, without forming strong adhesions that impede cell motility. It propels rapid dendritic cell migration controlled by extracellular chemicals, as well as pathologically ...
Kentarou Baba   +15 more
wiley   +1 more source

Brain‐Inspired Polymer Dendrite Networks for Morphology‐Dependent Computing Hardware

open access: yesAdvanced Science, EarlyView.
Although process variability is often perceived as a drawback in electronics, this work harnesses the stochastic nature of electropolymerization as a powerful ally for computation. The resulting conductive polymer dendrites exhibit unique structure‐property relationships and support in memory computing, paving the way for the development of a new class
Corentin Scholaert   +3 more
wiley   +1 more source

Schwann cells modified to secrete MANF is a potential cellular therapy for peripheral nerve regeneration. [PDF]

open access: yesCell Regen
Sivakumar B   +6 more
europepmc   +1 more source

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