Results 71 to 80 of about 448,604 (375)

Large-Scale Mapping of Axonal Arbors Using High-Density Microelectrode Arrays

Frontiers in Cellular Neuroscience, 2019
Understanding the role of axons in neuronal information processing is a fundamental task in neuroscience. Over the last years, sophisticated patch-clamp investigations have provided unexpected and exciting data on axonal phenomena and functioning, but ...
Torsten Bullmann, Torsten Bullmann, Torsten Bullmann, Milos Radivojevic, Stefan T. Huber, Kosmas Deligkaris, Kosmas Deligkaris, Andreas Hierlemann, Urs Frey, Urs Frey, Urs Frey   +10 more
doaj   +1 more source

Potent spinal parenchymal AAV9-mediated gene delivery by subpial injection in adult rats and pigs. [PDF]

, 2016
Effective in vivo use of adeno-associated virus (AAV)-based vectors to achieve gene-specific silencing or upregulation in the central nervous system has been limited by the inability to provide more than limited deep parenchymal expression in adult ...
Ahrens, Eric T, Ciacci, Joseph, Cleveland, Don, Curtis, Erik, Gabel, Brandon, Hruska-Plochan, Marian, Juhas, Stefan, Juhasova, Jana, Kamizato, Kota, Kaspar, Brian K, Lukacova, Nada, Marsala, Martin, Marsala, Silvia, Miyanohara, Atsushi, Navarro, Michael   +14 more
core   +3 more sources

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

Species and Sex Differences in the Morphogenic Response of Primary Rodent Neurons to 3,3′-Dichlorobiphenyl (PCB 11)

Toxics, 2017
PCB 11 is an emerging global pollutant that we recently showed promotes axonal and dendritic growth in primary rat neuronal cell cultures. Here, we address the influence of sex and species on neuronal responses to PCB 11.
Sunjay Sethi, Kimberly P. Keil, Pamela J. Lein   +2 more
doaj   +1 more source

Polychlorinated Biphenyls (PCBs): Risk Factors for Autism Spectrum Disorder?

Toxics, 2020
Autism spectrum disorder (ASD) includes a group of multifactorial neurodevelopmental disorders defined clinically by core deficits in social reciprocity and communication, restrictive interests and repetitive behaviors.
Harmanpreet Kaur Panesar, Conner L. Kennedy, Kimberly P. Keil Stietz, Pamela J. Lein   +3 more
doaj   +1 more source

Atypical Extracellular Action Potentials from Posteromedial Hypothalamus in Anesthetized Humans

Frontiers in Bioscience-Landmark, 2022
Background: We obtained microelectrode recordings from four patients with intractable aggressivity who underwent surgery at posteromedial hypothalamus under general anaesthesia.
Jesús Pastor, Lorena Vega-Zelaya, Elena Martín-Abad   +2 more
doaj   +1 more source

Effects of lipopolysaccharide-induced inflammation on expression of growth-associated genes by corticospinal neurons [PDF]

, 2006
Background: Inflammation around cell bodies of primary sensory neurons and retinal ganglion cells enhances expression of neuronal growth-associated genes and stimulates axonal regeneration.
Anderson, PN, Hossain-Ibrahim, MK, Lieberman, AR, MacNally, JK, Mason, MRJ, Rezajooi, K   +5 more
core   +2 more sources

Why Do Axons Differ in Caliber?

Journal of Neuroscience, 2012
CNS axons differ in diameter (d) by nearly 100-fold (∼0.1–10 μm); therefore, they differ in cross-sectional area (d2) and volume by nearly 10,000-fold.
J. Perge, J. Niven, E. Mugnaini, V. Balasubramanian, P. Sterling   +4 more
semanticscholar   +1 more source

Relapsing–Remitting Multiple Sclerosis Is Associated With a Dysbiotic Oral Microbiome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a chronic autoimmune disorder characterized by inflammation, demyelination, and neurological impairment. While the gut microbiota's role in MS is extensively studied, the association between the oral microbiota and MS remains underexplored, particularly in North American cohorts.
Sukirth M. Ganesan, Meeta Yadav, Sudeep Ghimire, Peter C. Lehman, Apurva J. Patel, Sydney Woods, Heena Olalde, Jemmie Hoang, Mishelle Paullus, Catherine Cherwin, Christine Gill, Tracey Cho, Ashutosh K. Mangalam   +12 more
wiley   +1 more source

Spinal cord injury regulates circular RNA expression in axons

Frontiers in Molecular Neuroscience, 2023
IntroductionNeurons transport mRNA and translational machinery to axons for local translation. After spinal cord injury (SCI), de novo translation is assumed to enable neurorepair. Knowledge of the identity of axonal mRNAs that participate in neurorepair
Mustafa M. Siddiq, Carlos A. Toro, Carlos A. Toro, Nicholas P. Johnson, Jens Hansen, Yuguang Xiong, Wilfredo Mellado, Rosa E. Tolentino, Kaitlin Johnson, Gomathi Jayaraman, Zaara Suhail, Lauren Harlow, Lauren Harlow, Jinye Dai, Jinye Dai, Jinye Dai, Kristin G. Beaumont, Kristin G. Beaumont, Robert Sebra, Robert Sebra, Dianna E. Willis, Dianna E. Willis, Christopher P. Cardozo, Christopher P. Cardozo, Christopher P. Cardozo, Ravi Iyengar   +25 more
doaj   +1 more source