Results 11 to 20 of about 3,581 (133)

Photochemical Deracemization of Chromanes and its Application to the Synthesis of Enantiopure Bioactive Compounds. [PDF]

Angew Chem Int Ed Engl
Various substituted chromane‐2‐carboxamides were successfully deracemized by employing a chiral benzophenone (BP, 10 mol%) as photocatalyst and an achiral thiol as additive (20 mol%). The method was applied to the concise enantioselective synthesis of five active pharmaceutical ingredients.
Ghosh B, Iglhaut M, Babushkina D, Pauls M, Bannwarth C, Bach T.   +5 more
europepmc   +3 more sources

Antiprotozoal Activity of Azabicyclo-Nonanes Linked to Tetrazole or Sulfonamide Cores

Molecules, 2022
N-(Aminoalkyl)azabicyclo[3.2.2]nonanes possess antiplasmodial and antitrypanosomal activity. A series with terminal tetrazole or sulfonamido partial structure was prepared. The structures of all new compounds were confirmed by NMR and IR spectroscopy and
Johanna Dolensky, Clemens Hinteregger, Andreas Leitner, Werner Seebacher, Robert Saf, Ferdinand Belaj, Pascal Mäser, Marcel Kaiser, Robert Weis   +8 more
doaj   +1 more source

Efficient and regioselective synthesis of dihydroxy-substituted 2-aminocyclooctane-1-carboxylic acid and its bicyclic derivatives

Beilstein Journal of Organic Chemistry, 2022
The first synthesis of 2-amino-3,4-dihydroxycyclooctane-1-carboxylic acid, methyl 6-hydroxy-9-oxo-8-oxabicyclo[5.2.1]decan-10-yl)carbamate, and 10-amino-6-hydroxy-8-oxabicyclo[5.2.1]decan-9-one starting from cis-9-azabicyclo[6.2.0]dec-6-en-10-one is ...
İlknur Polat, Selçuk Eşsiz, Uğur Bozkaya, Emine Salamci   +3 more
doaj   +1 more source

Reaction of quinaldine with 4,6-di(tert-butyl)-3-nitro-1,2-benzoquinone. Dependence of the outcome on the reaction conditions and a deeper insight into the mechanism

Heliyon, 2023
Condensation of quinaldine with 4,6-di (tert-butyl)-3-nitro-1,2-benzoquinone results in the formation of 5,7-di (tert-butyl)-2-(quinoline-2-yl)-1,3-tropolone, 5,7-di (tert-butyl)-4-nitro-2-(quinoline-2-yl)-1,3-tropolone, 3,3-dimethyl-2-(5-hydroxy-4-nitro-
Tatyana A. Krasnikova, Yurii A. Sayapin, Inna O. Tupaeva, Eugeny A. Gusakov, Ilya V. Ozhogin, Anton V. Lisovin, Mikhail V. Nikogosov, Oleg P. Demidov, Duong Nghia Bang, Tran Dai Lam, Nguyen Thi Thu Trang, Alexander D. Dubonosov, Vladimir I. Minkin   +12 more
doaj   +1 more source

Biological Evaluation and Theoretical Study of Bi-dentate Ligand for Amoxicillin Derivative with Some Metal Ions

مجلة بغداد للعلوم, 2021
In this paper, the complexes of Shiff base of Methyl -6-[2-(diphenylmethylene)amino)-2-(4-hydroxyphenyl)acetamido]-2,2-dimethyl-5-oxo-1-thia-4-azabicyclo[3.2.0]heptane-3-carboxylate (L) with Cobalt(II), Nickel(II), Cupper(II) and Zinc(II) have been ...
Sahar S. Hassan, Nidhal M. Hassan, Shaymaa Rajab Baqer, Asmaa M. saleh   +3 more
doaj   +1 more source

Study of Cytotoxicity of Spiro-Fused [3-Azabicyclo[3.1.0]hexane]oxindoles against Tumor Cell Lines

Medical Sciences Forum, 2022
Oncological diseases are one of the most common public health problems and the second leading cause of death after cardiovascular disease. Natural products or synthetic compounds derived from natural products continue to be excellent sources for new drug
Anton A. Kornev, Stanislav V. Shmakov, Alexey S. Klyuchnikov, Alexey V. Artemov, Alexander V. Stepakov, Vitali M. Boitsov   +5 more
doaj   +1 more source

Highly selective synthesis of functionalized morphan derivatives through a multi-component cascade reaction of 3-formylchromones, 2-naphthols, and enaminones

Green Synthesis and Catalysis, 2023
A novel protocol for the preparation of highly functionalized 2-azabicyclo[3.3.1]nonane (morphan) derivatives via a multicomponent cascade reaction, involving 3-formylchromones, 2-naphthols, and enaminones in the ionic liquid [BMIM]PF6 as the solvent and
Xinling Cao, Yinggang Duan, Kaihong Lv, Zihan Lu, Yihua Chen, Shengjiao Yan   +5 more
doaj   +1 more source

Synthesis, Theoretical Study, and Biological Evaluation of Some Metal Ions with Ligand "Methyl -6-[2-(4-Hydroxyphenyl) -2-((1-Phenylethylidene) Amino) Acetamido] -2,2-Dimethyl-5—Oxo-1-Thia-4-Azabicyclo [3.2.0] Heptane-3-Carboxyylate

مجلة بغداد للعلوم, 2023
Schiff base (methyl 6-(2- (4-hydroxyphenyl) -2- (1-phenyl ethyl ideneamino) acetamido) -3, 3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0] heptane-2-carboxylate)Co(II), Ni(II), Cu (II), Zn (II), and Hg(II)] ions were employed to make certain complexes ...
Sahar S. Hassan, Nafeesa J. Kadhim , Zahraa. A. Jaber   +2 more
doaj   +1 more source

Unexpected Resistance to Base-Catalyzed Hydrolysis of Nitrogen Pyramidal Amides Based on the 7-Azabicyclic[2.2.1]heptane Scaffold

Molecules, 2018
Non-planar amides are usually transitional structures, that are involved in amide bond rotation and inversion of the nitrogen atom, but some ground-minimum non-planar amides have been reported.
Diego Antonio Ocampo Gutiérrez de Velasco, Aoze Su, Luhan Zhai, Satowa Kinoshita, Yuko Otani, Tomohiko Ohwada   +5 more
doaj   +1 more source

Discovery of a Potent Highly Biased MOR Partial Agonist among Diastereomeric C9-Hydroxyalkyl-5-phenylmorphans

Molecules, 2023
All possible diastereomeric C9-hydroxymethyl-, hydroxyethyl-, and hydroxypropyl-substituted 5-phenylmorphans were synthesized to explore the three-dimensional space around the C9 substituent in our search for potent MOR partial agonists.
Joshua A. Lutz, Agnieszka Sulima, Eugene S. Gutman, Eric W. Bow, Dan Luo, Sophia Kaska, Thomas E. Prisinzano, Carol A. Paronis, Jack Bergman, Gregory H. Imler, Andrew T. Kerr, Arthur E. Jacobson, Kenner C. Rice   +12 more
doaj   +1 more source