Results 21 to 30 of about 3,581 (133)

Exploration of Novel Mono Hydroxamic Acid Derivatives as Inhibitors for Histone Deacetylase Like Protein (HDLP) by Molecular Dynamics Studies

Indonesian Journal of Chemistry, 2022
The acetylation modification process of histone has an essential role in the epigenetic regulation of gene expression. This process is controlled by the balance between histone deacetylases (HDAC) and histone acetyltransferases (HAT).
Gunasingham Parthiban, Ramachandren Dushanan, Samantha Weerasinghe, Dhammike Dissanayake, Rajendram Senthilnithy   +4 more
doaj   +1 more source

Anomeric Amides: Valuable Reagents in Synthetic Organic Chemistry

Angewandte Chemie, Volume 138, Issue 12, 16 March 2026.
Enabling late‐stage transformations and skeletal editing, anomeric amides have recently emerged as powerful synthetic tools. Due to their unique properties, anomeric amides have been employed in reactions ranging from amination to halogenation. This minireview provides an overview of recent progress in using anomeric amides across a variety of ...
Arushi Garg, Jordan Vigier, Hélène Lebel, Tatiana Besset   +3 more
wiley   +2 more sources

A convenient synthesis of CHF₂O-containing pyrrolidines and related compounds — Perspective building blocks for drug discovery

SynOpen
Fluorine-containing organic molecules, including CHF2O-derivatives, are among the most sought-after in medicinal chemistry. In the current work, a mini-library of 21 compounds with a CHF2O-motif incorporated with azetidine, pyrrolidine (proline ...
Kostiantyn Levchenko, Ivan Virstiuk, Daria Menshykova, Nazariy Pokhodylo   +3 more
doaj   +1 more source

Studies on 1-Azabicyclo Compounds. XVI. Synthesis of 1'-Methylindan-2-spiro-2'-piperazine and Related Compounds

Chemical and Pharmaceutical Bulletin, 1973
A new synthesis of the spirodiamines (IIIa-c) from the methiodides (Ia-c) via the spiroaminolactams (VIIa-c) by Stevens rearrangement is described.
HIDEO KATO, EIICHI KOSHINAKA, YOSHIO ARATA, MIYOJI HANAOKA   +3 more
openaire   +2 more sources

Synthesis and characterization of Novel Schiff bases and evaluation of Corrosion inhibitors and biological activity

مجلة علوم ذي قار, 2019
Novel Schiff bases have been prepared from (6R,7R)-3-[( acetyloxy)methyl]-7-[[( Z)-2-(2aminothiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]-oct-2-ene-2carboxylate sodium and 2,4-dihydroxy benzaldehyde ,3-methoxy-4-hydroxy
Ahmed M. Jassim
doaj   +4 more sources

2,4-Bis(2-methylphenyl)-3-azabicyclo[3.3.1]nonan-9-one O-methyloxime

Acta Crystallographica Section E, 2010
The molecule of the title compound, C23H28N2O, exists in a twin-chair conformation, with equatorial orientation of the ortho-tolyl groups on both sides of the secondary amino group. The title oxime compound and its ketone precursor 2,4-bis(2-methylphenyl)
P. Parthiban, V. Ramkumar, Yeon Tae Jeong   +2 more
doaj   +1 more source

Photochemistry of Aromatic N‐Oxides in Water Probed by Time‐Resolved X‐ray Absorption Spectroscopy

Chemistry – A European Journal, EarlyView.
Time‐resolved XAS at the nitrogen and oxygen K‐edges is applied to the photorearrangement of two N‐oxides in water. Pyridine N‐oxide rapidly forms the oxaziridine isomer. Pyridazine N‐oxide undergoes ring opening to the diazo compound, without any evidence of intermediates.
Maximilian Paradiz Domínguez, Robby Büchner, Mattis Fondell, Albert M. Brouwer   +3 more
wiley   +1 more source

Strain‐Release Diversification of 1‐Azabicyclobutanes via Bromide/Nickel Relay Catalyzed 1,3‐Bis‐Carbofunctionalization

Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.
A four‐component synthesis of azetidines with an all‐carbon quaternary center via strain‐release 1,3‐bis‐carbofunctionalization of 1‐azabicyclobutanes (ABB) is described. Each reaction component can be modified to permit a high‐throughput‐like library preparation, producing azetidines with various appendages, including biorelevant molecules.
Yi‐Hua Lee, Che‐Ming Hsu, Shinje Miñoza, Ya‐Fang Shih, Yu‐Chun Ding, Tzu‐Yao Hsu, Song‐Ting Chen, Kuei‐Chen Chang, Wen‐Hsuan Lee, Yuya A. Lin, Hsuan‐Hung Liao   +10 more
wiley   +2 more sources

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, EarlyView.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Modified Synthesis of Four Kinds of Azabicyclo Compounds

Chinese Journal of Applied Chemistry, 2012
Azabicyclo compounds of 1,4-benxodiazine,pyridopyrazine,1H-benzimidazole,3H-imidazopyridine were prepared from o-phenylenediamine or 2,3-diaminopyridine reacted with carbonyl compounds.The effects of reaction medium,pH,time and other factors on the reactions were invesitigated.The results showed that the yield of pyridopyrazine could reach 89.4% when ...
openaire   +1 more source