Results 71 to 80 of about 976 (197)

Synthesis of the Azaphilones Using Copper‐Mediated Enantioselective Oxidative Dearomatization. [PDF]

ChemInform, 2005
An approach to the asymmetric synthesis of the azaphilone natural products is reported involving copper-mediated enantioselective oxidative dearomatization of o-alkynylbenzaldehydes. The approach was successfully applied to the synthesis of (-)-S-15183a and several unnatural azaphilones.
Jianglong, Zhu, Nicholas P, Grigoriadis, Jonathan P, Lee, John A, Porco   +3 more
openaire   +2 more sources

Undescribed Metabolites from an Actinobacteria Acrocarpospora punica and Their Anti-Inflammatory Activity

Molecules, 2022
In an effort to explore bioactive anti-inflammatory compounds from natural Actinobacteria resources from all over Taiwan and various ecological environments, an active strain of Acrocarpospora punica was collected at Taitung County in Taiwan, prepared ...
Ming-Der Wu, Ming-Jen Cheng
doaj   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, Volume 293, Issue 8, Page 2314-2340, April 2026.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro. [PDF]

PLoS ONE, 2017
The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3'-untranslated region (UTR) of target mRNAs. The HuR-ARE interactions stabilize many oncogenic mRNAs that play important roles in tumorigenesis. Thus, small molecules that
Kawaljit Kaur, Xiaoqing Wu, James K Fields, David K Johnson, Lan Lan, Miranda Pratt, Amber D Somoza, Clay C C Wang, John Karanicolas, Berl R Oakley, Liang Xu, Roberto N De Guzman   +11 more
doaj   +1 more source

Raw citrus by‐product valorization: unlocking the potential of biotransformation by Talaromyces amestolkiae to obtain cellulolytic enzymes and natural colorants

Biofuels, Bioproducts and Biorefining, Volume 20, Issue 2, Page 806-816, March/April 2026.
Abstract Agro‐industrial by‐products can be used as valuable nutrient sources for the sustainable production of high‐value‐added compounds. The goal of this study was utilize raw citrus industrial by‐product (RCB) as a carbon source for the simultaneous production of red colorants and enzymes by the filamentous fungus Talaromyces amestolkiae under lab ...
Caio de Azevedo Lima, Heitor B. S. Bento, Flávio Pereira Picheli, Fernanda de Oliveira, Almiro Pires da Silva Neto, Danielle Biscaro Pedrolli, Fernando Masarin, Silvio Silvério da Silva, Valéria Carvalho Santos‐Ebinuma   +8 more
wiley   +1 more source

Reengineering an Azaphilone Biosynthesis Pathway in Aspergillus nidulans To Create Lipoxygenase Inhibitors

, 2016
Sclerotiorin, an azaphilone polyketide, is a bioactive natural product known to inhibit 15-lipoxygenase and many other biological targets. To readily access sclerotiorin and analogs, we developed a 2–3 step semisynthetic route to produce a variety of ...
Yi-Ming Chiang (1312392), Berl R. Oakley (183341), Clay C. C. Wang (313310), Amber D. Somoza (2112829), Kuan-Han Lee (313313)   +4 more
core   +1 more source

Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products

Acta Pharmaceutica Sinica B, 2021
Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene clusters, exhibited its strong ability to produce numbers of ...
Qian Wei, Jian Bai, Daojiang Yan, Xiuqi Bao, Wenting Li, Bingyu Liu, Dan Zhang, Xiangbing Qi, Dequan Yu, Youcai Hu   +9 more
doaj   +1 more source

Electronic Nose for Indoor Mold Detection and Identification

Advanced Sensor Research, Volume 5, Issue 2, February 2026.
This study explores the potential of a SnO2 nanowire‐based chemiresistive electronic nose not only to detect but also to identify two common indoor mold species, Stachybotrys chartarum and Chaetomium globosum on two different growth substrates. In a laboratory setup, the electronic nose displays high classification performance using optimized linear ...
Hankun Yang, Martin Sommer, Stephanie Bauer, Uli Lemmer   +3 more
wiley   +1 more source

NARS1 Enhances HCC Proliferation by Stimulating NF‐κB Signaling Pathway

Human Mutation, Volume 2026, Issue 1, 2026.
Background Hepatocellular carcinoma (HCC) is still an important risk to public health, and its pathogenesis is still unclear. Therefore, it is important to probe the HCC pathogenesis and constantly find new diagnostic and therapeutic targets in HCC markers.
Peng Huang, Dakun Zhao, Lingjian Li, Cuixia Liu, Yin Yuan, Huimin Guo, Hexu Han, Lin Zhang   +7 more
wiley   +1 more source

Deletion of the Class 1 Histone Deacetylase PsHos2 Induces Secondary Metabolic Perturbations in the Sea Cucumber-Associated Penicillium sclerotiorum

Fermentation
The long-term coexistence of sea cucumber-associated microorganisms with their host enables them to jointly withstand the unique marine ecological environment, and possess great potential for producing various natural products.
Peipei Zhao, Jiaying Lin, Qingqing Zhang, Tanghui Zhang, Guoliang Zhu, Chengwei Liu, Qinghua Wu, Jianzhao Qi, Minglei Li, Lixin Zhang, Xuekui Xia   +10 more
doaj   +1 more source