Results 71 to 80 of about 911 (193)

NARS1 Enhances HCC Proliferation by Stimulating NF‐κB Signaling Pathway

Human Mutation, Volume 2026, Issue 1, 2026.
Background Hepatocellular carcinoma (HCC) is still an important risk to public health, and its pathogenesis is still unclear. Therefore, it is important to probe the HCC pathogenesis and constantly find new diagnostic and therapeutic targets in HCC markers.
Peng Huang, Dakun Zhao, Lingjian Li, Cuixia Liu, Yin Yuan, Huimin Guo, Hexu Han, Lin Zhang   +7 more
wiley   +1 more source

Reengineering an Azaphilone Biosynthesis Pathway in Aspergillus nidulans To Create Lipoxygenase Inhibitors

, 2016
Sclerotiorin, an azaphilone polyketide, is a bioactive natural product known to inhibit 15-lipoxygenase and many other biological targets. To readily access sclerotiorin and analogs, we developed a 2–3 step semisynthetic route to produce a variety of ...
Yi-Ming Chiang (1312392), Berl R. Oakley (183341), Clay C. C. Wang (313310), Amber D. Somoza (2112829), Kuan-Han Lee (313313)   +4 more
core   +1 more source

Undescribed Metabolites from an Actinobacteria Acrocarpospora punica and Their Anti-Inflammatory Activity

Molecules, 2022
In an effort to explore bioactive anti-inflammatory compounds from natural Actinobacteria resources from all over Taiwan and various ecological environments, an active strain of Acrocarpospora punica was collected at Taitung County in Taiwan, prepared ...
Ming-Der Wu, Ming-Jen Cheng
doaj   +1 more source

Harnessing Molecular and Bioactivity Network Analysis to Prioritize Antibacterial Compound Isolation From Ant‐Associated Fungi

Phytochemical Analysis, Volume 36, Issue 5, Page 1351-1366, July 2025.
ABSTRACT Introduction Antimicrobial resistance is a global public health problem that requires the development of new bioactive compounds. In this context, metabolomic analyses can expedite the research of fungal metabolites as a valuable resource. Objectives To investigate the metabolic profiles and isolate antibacterial compounds from micromycetes ...
Ángel S. Aguilar‐Colorado, Jesús Morales‐Jiménez, José Rivera‐Chávez   +2 more
wiley   +1 more source

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro. [PDF]

PLoS ONE, 2017
The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3'-untranslated region (UTR) of target mRNAs. The HuR-ARE interactions stabilize many oncogenic mRNAs that play important roles in tumorigenesis. Thus, small molecules that
Kawaljit Kaur, Xiaoqing Wu, James K Fields, David K Johnson, Lan Lan, Miranda Pratt, Amber D Somoza, Clay C C Wang, John Karanicolas, Berl R Oakley, Liang Xu, Roberto N De Guzman   +11 more
doaj   +1 more source

Lienhwalides: Unique Tropolone–Maleidride Hybrids from Hypoxylon lienhwacheense

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
Lienhwalides are novel tropolone–maleidride hybrid molecules unique in nature. Absolute configuration is solved by semisynthetic approaches and X‐ray analysis. Interplay between both lwt and lwm biosynthetic gene clusters is responsible for the production of lienhwalides.
Katharina Schmidt, Esteban Charria‐Girón, Tatiana E. Gorelik, Christian Kleeberg, Jackson M. Muema, Simone Heitkämper, Bart Verwaaijen, Eric Kuhnert, Jennifer Gerke, Jörn Kalinowski, Kevin D. Hyde, Marc Stadler, Russell Cox, Frank Surup   +13 more
wiley   +1 more source

Synthesis of the Azaphilones Using Copper‐Mediated Enantioselective Oxidative Dearomatization. [PDF]

ChemInform, 2005
An approach to the asymmetric synthesis of the azaphilone natural products is reported involving copper-mediated enantioselective oxidative dearomatization of o-alkynylbenzaldehydes. The approach was successfully applied to the synthesis of (-)-S-15183a and several unnatural azaphilones.
Jianglong, Zhu, Nicholas P, Grigoriadis, Jonathan P, Lee, John A, Porco   +3 more
openaire   +2 more sources

Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products

Acta Pharmaceutica Sinica B, 2021
Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene clusters, exhibited its strong ability to produce numbers of ...
Qian Wei, Jian Bai, Daojiang Yan, Xiuqi Bao, Wenting Li, Bingyu Liu, Dan Zhang, Xiangbing Qi, Dequan Yu, Youcai Hu   +9 more
doaj   +1 more source

Biofertilizer Industry and Research Developments in China: A Mini‐Review

Microbial Biotechnology, Volume 18, Issue 5, May 2025.
This review discusses the transition from chemical fertilizers to biofertilizers in China, highlighting the risks of chemical overuse, the booming biofertilizer market, and regulatory support. It also explores the challenges in biofertilizer development and advances in microbial research in China, highlighting biofertilizers' role in enhancing ...
Xinli Sun, Zhihui Xu, Nan Zhang, Youzhi Miao, Chao Zhang, Xiaoli Ma, Qirong Shen, Ruifu Zhang   +7 more
wiley   +1 more source

Azaphilone Alkaloids with Anti-inflammatory Activity from Fungus Penicillium sclerotiorum cib-411

, 2019
Nine new azaphilone alkaloids, penazaphilones A–I (1–9), were isolated from the solid fermented rice culture of Penicillium sclerotiorum cib-411. The structures of compounds 1–9 were elucidated based on HRESIMS, NMR, and CD spectroscopic data.
Zong-Yuan Zhou (6336536), Lin-Wei Wu (1561873), Jia-Lin Tang (6336533), Guo-You Li (676444), Can Yao (6336539), Tao Yang (184280)   +5 more
core   +3 more sources