Results 81 to 90 of about 912 (190)

Genome mining combined metabolic shunting and OSMAC strategy of an endophytic fungus leads to the production of diverse natural products

Acta Pharmaceutica Sinica B, 2021
Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene clusters, exhibited its strong ability to produce numbers of ...
Qian Wei, Jian Bai, Daojiang Yan, Xiuqi Bao, Wenting Li, Bingyu Liu, Dan Zhang, Xiangbing Qi, Dequan Yu, Youcai Hu   +9 more
doaj   +1 more source

Harnessing Molecular and Bioactivity Network Analysis to Prioritize Antibacterial Compound Isolation From Ant‐Associated Fungi

Phytochemical Analysis, Volume 36, Issue 5, Page 1351-1366, July 2025.
ABSTRACT Introduction Antimicrobial resistance is a global public health problem that requires the development of new bioactive compounds. In this context, metabolomic analyses can expedite the research of fungal metabolites as a valuable resource. Objectives To investigate the metabolic profiles and isolate antibacterial compounds from micromycetes ...
Ángel S. Aguilar‐Colorado, Jesús Morales‐Jiménez, José Rivera‐Chávez   +2 more
wiley   +1 more source

Synthesis of the Azaphilones Using Copper‐Mediated Enantioselective Oxidative Dearomatization. [PDF]

ChemInform, 2005
An approach to the asymmetric synthesis of the azaphilone natural products is reported involving copper-mediated enantioselective oxidative dearomatization of o-alkynylbenzaldehydes. The approach was successfully applied to the synthesis of (-)-S-15183a and several unnatural azaphilones.
Jianglong, Zhu, Nicholas P, Grigoriadis, Jonathan P, Lee, John A, Porco   +3 more
openaire   +2 more sources

Lienhwalides: Unique Tropolone–Maleidride Hybrids from Hypoxylon lienhwacheense

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
Lienhwalides are novel tropolone–maleidride hybrid molecules unique in nature. Absolute configuration is solved by semisynthetic approaches and X‐ray analysis. Interplay between both lwt and lwm biosynthetic gene clusters is responsible for the production of lienhwalides.
Katharina Schmidt, Esteban Charria‐Girón, Tatiana E. Gorelik, Christian Kleeberg, Jackson M. Muema, Simone Heitkämper, Bart Verwaaijen, Eric Kuhnert, Jennifer Gerke, Jörn Kalinowski, Kevin D. Hyde, Marc Stadler, Russell Cox, Frank Surup   +13 more
wiley   +1 more source

Biofertilizer Industry and Research Developments in China: A Mini‐Review

Microbial Biotechnology, Volume 18, Issue 5, May 2025.
This review discusses the transition from chemical fertilizers to biofertilizers in China, highlighting the risks of chemical overuse, the booming biofertilizer market, and regulatory support. It also explores the challenges in biofertilizer development and advances in microbial research in China, highlighting biofertilizers' role in enhancing ...
Xinli Sun, Zhihui Xu, Nan Zhang, Youzhi Miao, Chao Zhang, Xiaoli Ma, Qirong Shen, Ruifu Zhang   +7 more
wiley   +1 more source

Deletion of the Class 1 Histone Deacetylase PsHos2 Induces Secondary Metabolic Perturbations in the Sea Cucumber-Associated Penicillium sclerotiorum

Fermentation
The long-term coexistence of sea cucumber-associated microorganisms with their host enables them to jointly withstand the unique marine ecological environment, and possess great potential for producing various natural products.
Peipei Zhao, Jiaying Lin, Qingqing Zhang, Tanghui Zhang, Guoliang Zhu, Chengwei Liu, Qinghua Wu, Jianzhao Qi, Minglei Li, Lixin Zhang, Xuekui Xia   +10 more
doaj   +1 more source

Neuraminidase Inhibitors from the Fruiting Body of Glaziella splendens

Mycobiology, 2019
Neuraminidase (NA) cleaves the glycosidic bond linkages of sialic acids to release the mature virions from infected cells and has been an attractive therapeutic target for anti-influenza agents.
Ji-Yul Kim, E-Eum Woo, Lee Su Ha, Dae-Won Ki, In-Kyoung Lee, Bong-Sik Yun   +5 more
doaj   +1 more source

Talaromyces atroroseus, a new species efficiently producing industrially relevant red pigments. [PDF]

PLoS ONE, 2013
Some species of Talaromyces secrete large amounts of red pigments. Literature has linked this character to species such as Talaromyces purpurogenus, T. albobiverticillius, T. marneffei, and T. minioluteus often under earlier Penicillium names.
Jens C Frisvad, Neriman Yilmaz, Ulf Thrane, Kasper Bøwig Rasmussen, Jos Houbraken, Robert A Samson   +5 more
doaj   +1 more source

Scientific Opinion on additional scientific data related to the safety of monacolins from red yeast rice submitted pursuant to Article 8(4) of Regulation (EC) No 1925/2006

EFSA Journal, Volume 23, Issue 2, February 2025.
Abstract The Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver a scientific opinion on the safety of monacolins from red yeast rice (RYR), which have been placed under Union scrutiny in Part C of Annex III in accordance with Article 8(4) of Regulation (EC) No 1925/2006.
EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Dominique Turck, Torsten Bohn, Montaña Cámara, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, Ángeles Jos, Inge Mangelsdorf, Breige McNulty, Androniki Naska, Kristina Pentieva, Alfonso Siani, Frank Thies, Leonard Matijević, Silvia Valtueña Martinez, Alexandre Maciuk   +17 more
wiley   +1 more source

Red Yeast Rice or Lovastatin? A Comparative Evaluation of Safety and Efficacy Through a Multifaceted Approach

Phytotherapy Research, Volume 39, Issue 1, Page 264-281, January 2025.
ABSTRACT The increasing use of red yeast rice (RYR) as a natural supplement to manage blood cholesterol levels is driven by its active compound, monacolin K (MK), which is chemically identical to the statin drug lovastatin (LOV). Despite its growing popularity, concerns persists regarding the safety and efficacy of RYR compared to pure statins.
Giovanna Rigillo, Giulia Baini, Renato Bruni, Giulia Puja, Elisabetta Miraldi, Luca Pani, Fabio Tascedda, Marco Biagi   +7 more
wiley   +1 more source