Results 71 to 80 of about 799 (135)

Total Synthesis of 8-Azasteroids

Russian Chemical Reviews, 1984
Studies on the total synthesis of 8-azasteroids from the start of investigations in this field (1963) up to 1983 are examined. Earlier studies on the synthesis of compounds formally containing the 8-azasteroid skeleton and those on the synthesis of 8-azasteroids with an additional heteroatom are also analysed.
F. Lakhvich, L. Lis, A. A. Akhrem
semanticscholar   +2 more sources

Synthesis of phenanthridones, quinolinequinones and 7-azasteroids

Tetrahedron, 1999
Abstract Cleavage of ring D of lycorines, obtained by an intramolecular cycloaddition of an aryne to an azadiene, led to phenanthridines, which were either oxidized to quinolinequinones or cyclized to 7-azasteroids, both of which families are of potential pharmacological interest.
Concepción C. González, E. Guitián, L. Castedo   +2 more
semanticscholar   +2 more sources

Azasteroids from diosgenin: Synthesis and evaluation of their antiproliferative activity.

Steroids, 2020
In this work, we report the synthesis of two new azasteroids through the modification of the A and B rings of diosgenin 1. The 4-azasteroid derivative 12 was prepared in three steps using the α,β-insaturated-3-keto compound 11 as a precursor, which was ...
Anselmo A. Martínez-Gallegos, Gabriel Guerrero-Luna, Alejandra Ortiz-González, M. Cárdenas-García, S. Bernès, María Guadalupe Hernández-Linares   +5 more
semanticscholar   +1 more source

ChemInform Abstract: AZASTEROIDE 1. MITT. SYNTH. EINES AZASTEROID‐RINGSYST.

Chemischer Informationsdienst. Organische Chemie, 1970
AbstractBeim Erhitzen von 2‐(1‐Cyclohexenyl)‐ähhylamin (I) mit dem Ester (II) am Rückfluß entsteht das Enaminlactam (III) (als Doppelbindungsisomerengemisch) in einer Ausbeute von 86%.
S. OHKI, M. AKIBA
openaire   +1 more source

N-Alkylation of 17-azasteroids

Steroids, 1994
N-Alkylation of 17-azasteroid lactams (16-oxo-17-azaandrost-5-en-3 beta-ol acetate 3 and its D-homo analog 4) was studied. It has been found that both lactams are readily alkylated with iodomethane or iodoethane. In contrast to this there was no reaction with 2-iodo-6-methylheptane due to the steric hindrance.
J W, Morzycki, Z, Lotowski
openaire   +2 more sources

Discovery and Development of Azasteroids as Anticancer Agents.

Steroids, 2019
Cancer is the second leading cause of death worldwide following cardiovascular diseases. Cancer can be treated by a variety of techniques including surgery, radiation therapy, immunotherapy, and chemotherapy.
N. Birudukota, Mukesh Madan Mudgal, V. Shanbhag   +2 more
semanticscholar   +1 more source

14-azasteroids via heterocycloaddition

Tetrahedron, 1978
Abstract Benzo[f]quinoline alcohol 1 has been converted into azasteroids 14 and 15 via a standard procedure and via application of the newly discovered 1.4 aryl radical rearrangement of α-halomethyl-N-arylsutfonylpiperidioes. An intramolecular accelerating effect of an OH group on LAH reductions of N-tosylamides is described.
R.P. Loven, W.N. Speckamp
openaire   +1 more source

7-azasteroid analogues—I

Tetrahedron, 1973
Abstract Although 7-methoxy- and 6,7-dimethoxy-2-methyl-4-vinyl-isocarbostyrils could not be isolated and characterised, they have been generated in situ and shown to undergo cyclo-addition reactions with typical dienophiles. The enol acetate of 2-methyl-4-acetylisocarbostyril has also been trapped as its adduct with maleic anhydride and with p ...
S.F. Dyke, P.A. Bather, A.B. Garry, D.W. Wiggins   +3 more
openaire   +1 more source

Synthesis of 8‐Azasteroids

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
H. Surya Prakash Rao, S. P. Senthilkumar
openaire   +1 more source

Phosphorescence of 8-azasteroids and related compounds

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2005
We have investigated the electron absorption, fluorescence and phosphorescence spectra of 8-azasteroids and model compounds containing enaminodicarbonyl fragment. It has been shown that the investigated compounds have absorption and phosphorescence spectra similar in form and position.
S A, Bagnich, N N, Khropik, V N, Knyukshto, A L, Mikhalchuk, D B, Rubinov   +4 more
openaire   +2 more sources