Results 91 to 100 of about 5,133 (208)

Novel methodology development for 3,3-disubstituted azetidine synthesis via organometallic catalysis

, 2021
Nitrogen-containing heterocyclic molecules have a very important position in medicinal chemistry. Piperidine and pyrrolidine are more common saturated nitrogen-containing heterocyclic molecules.
Fang, Zih-Chi
core  

The Nitrofuran-Warhead-Equipped Spirocyclic Azetidines Show Excellent Activity against Mycobacterium tuberculosis

Molecules
A series of 21 new 7′H-spiro[azetidine-3,5′-furo [3,4-d]pyrimidine]s substituted at the pyrimidine ring second position were synthesized. The compounds showed high antibacterial in vitro activity against M. tuberculosis.
Kristina Komarova, Lyubov Vinogradova, Alexey Lukin, Maxim Zhuravlev, Dmitry Deniskin, Mikhail Chudinov, Maxim Gureev, Marine Dogonadze, Natalia Zabolotnykh, Tatiana Vinogradova, Anastasia Lavrova, Petr Yablonskiy   +11 more
doaj   +1 more source

In-silico molecular docking, ADME study of new azetidin-2-one derivatives having imidazole moiety targeting cyclooxygenase-2 Enzyme

Al-Mustansiriyah Journal of Pharmaceutical Sciences
Background: Non-steroidal anti-inflammatory drugs re commonly used medications as anti-inflammatory, analgesic and antipyretic agents. However, they have many limitations due to the adverse effect, such as gastric irritation and gastric ulceration ...
Aya Ahmed Shakir Hasson , Monther Faisal Mahdi   +1 more
doaj   +1 more source

Recent advances in the late-stage modification of complex bioactive molecules with oxetanes and azetidines

Tetrahedron Chem
Oxetanes and azetidines have emerged as increasingly prominent motifs in medicinal chemistry, offering compact, polar frameworks that finely modulate the physicochemical properties of drug candidates.
Yuqing Wang, Dayu Tian, Hai-Jun Zhang
doaj   +1 more source

Molecular basis for azetidine-2-carboxylic acid biosynthesis

Nature Communications
Azetidine-2-carboxylic acid (AZE) is a long-known plant metabolite. Recently, AZE synthases have been identified in bacterial natural product pathways involving non-ribosomal peptide synthetases.
Tim J. Klaubert, Jonas Gellner, Charles Bernard, Juliana Effert, Carine Lombard, Ville R. I. Kaila, Helge B. Bode, Yanyan Li, Michael Groll   +8 more
doaj   +1 more source

Azetidines [PDF]

Chemical & Engineering News Archive, 2014
openaire   +1 more source

Azetidine Analogues Nucleosidase And Phosphorylase Inhibitors

, 2014
This invention relates to certain azetidine analogues of nucleosidase and nucleoside phosphorylase inhibitors, the use of these compounds as pharmaceuticals, pharmaceutical compositions containing the compounds, methods of treating certain diseases using
Greatrex, Ben, Schrramm, Vern L, Furneaux, Richard Hubert, Evans, Gary Brian, Tyler, Peter Charles   +4 more
core  

In situ azetidine polymerization elevates the performance of commercial polymer resin sorbents in carbon dioxide capture. [PDF]

Sci Adv
Giri A, Ryu U, Zhang J, Ojelade O, Zhao W, Hoffman J, Robertson M, Espín J, Nichols M, Parker S, Nik OG, Jones CW.   +11 more
europepmc   +1 more source

Directed biosynthesis of the designer peptidyl nucleoside antibiotics featuring a simplified azetidine-containing moiety. [PDF]

Synth Syst Biotechnol
Gong R, Li T, Zhou L, Liu Y, Zhang T, Qin Y, Zeng X, Jin B, Wang J, Deng Z, Song X, Chen W.   +11 more
europepmc   +1 more source

Modular synthesis of functionalized azetidines through visible-light copper-catalyzed carboamination of 1,3-dienes with azabicyclo[1.1.0]butanes. [PDF]

Chem Sci
Koo Y, Lee D, Park J, Hong S.
europepmc   +1 more source