Synthesis and reactivity of 4-(trifluoromethyl)azetidin-2-ones [PDF]
, 2018 Because of the beneficial effect of a trifluoromethyl group on the biological properties of bioactive compounds on the one hand and the versatile synthetic potential of beta-lactams on the other hand, 4-CF3-beta-lactams comprises interesting entities for
D'hooghe, Matthias +2 more
core +1 more source
Chemical modeling for predicting the abundances of certain aldimines and amines in hot cores
, 2021 We consider six isomeric groups (CH3N, CH5N, C2H5N, C2H7N, C3H7N and C3H9N) to review the presence of amines and aldimines within the interstellar medium (ISM). Each of these groups contains at least one aldimine or amine.
Bhat, Bratati +5 more
core +1 more source
CHIMIA, 2023 4-Membered heterocycles are low molecular weight polar scaffolds with intriguing potential for drug discovery. Despite their unquestionable value, methods to access such heterocycles remain scant.
Juan J. Rojas, James A. Bull
doaj +1 more source
Studies on the Interaction of Isocyanides with Imines: Reaction Scope and Mechanistic Variations [PDF]
, 2018 The interaction of imines with isocyanides has been studied. The main product results from a sequential process involving the attack of two units of isocyanide, under Lewis acid catalysis, upon the carbon-nitrogen double bond of the imine to form the 4 ...
Ghashghaei, Ouldouz +4 more
core +1 more source
Arylhydrazines: Convenient Homogeneous Reductants for Scalable Cross‐Coupling
Angewandte Chemie, Volume 138, Issue 12, 16 March 2026.Reductive cross‐couplings enable efficient C–C bond formation but are limited by the heterogeneity of Zn or costly reagents like TDAE. We report arylhydrazines as inexpensive, convenient reductants for Ni‐catalyzed sp2–sp3 coupling of aryl halides and secondary alkyl iodides. Mechanistic studies support hydrazine‐mediated NiII reduction for a NiI/NiIII
Nils Kurig +5 more
wiley +2 more sources
Chemical investigation of light induced DNA bipyrimidine damage and repair [PDF]
, 2011 In all organisms, genetic information is stored in DNA and RNA. Both of these macromolecules are damaged by many exogenous and endogenous events, with UV irradiation being one of the major sources of damage.
Carell, Thomas +2 more
core +1 more source
Amino acid analog toxicity in primary rat neuronal and astrocyte cultures: implications for protein misfolding and tdp-43 regulation [PDF]
, 2011 Amino acid analogs promote translational errors that result in aberrant protein synthesis, and have been used to understand the effects of protein misfolding in a variety of physiological and pathological settings.
Dasuri, Kalavathi +3 more
core +5 more sources
Structural basis of malaria parasite phenylalanine tRNA-synthetase inhibition by bicyclic azetidines
Nature Communications, 2021 Bicyclic azetidine inhibitors are promising antimalarials that target the Plasmodium cytosolic phenylalanine tRNAsynthetase (cFRS). Here, Sharma et al.
Manmohan Sharma +11 more
doaj +1 more source
Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands [PDF]
, 2015 Short chain fatty acids (SCFAs) are produced in the gut by bacterial fermentation of poorly digested carbohydrates. A key mediator of their actions is the G protein-coupled Free Fatty Acid 2 (FFA2) receptor and this has been suggested as a therapeutic ...
Hansen, Anders Højgaard +6 more
core +2 more sources
Frontiers in Chemistry, 2019 A new synthetic route to N-alkyl-2-acylazetidines was developed through a highly stereoselective addition of organolithiums to N-alkyl-2-oxazolinylazetidines followed by acidic hydrolysis of the resulting oxazolidine intermediates. This study revealed an
Pantaleo Musci +8 more
doaj +1 more source