Synthesis and late-stage functionalization of complex molecules through C-H fluorination and nucleophilic aromatic substitution. [PDF]
, 2014 We report the late-stage functionalization of multisubstituted pyridines and diazines at the position α to nitrogen. By this process, a series of functional groups and substituents bound to the ring through nitrogen, oxygen, sulfur, or carbon are ...
Fier, Patrick S, Hartwig, John F
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Sulfur Ylides in Skeletal‐Editing—Ring Expansion Reactions
Helvetica Chimica Acta, Volume 109, Issue 3, March 2026.Sulfur ylides (S‐ylides) are emergent diazo surrogates that enable skeletal editing and ring expansion with safer handling and broad functional group tolerance. This perspective covers pioneer works and highlights recent advances in the field, while outlining key challenges and future directions that may redefine the role of S‐ylides in modern ...
Arsala Kamal +3 more
wiley +1 more source
Structure and activity relationships for amine-based CO2 absorbents-II [PDF]
, 2009 A study to determine the structure and activity relationships of various amine-based CO2 absorbents was performed, in which the absorption of pure CO2 at atmospheric pressure was measured to assess the total absorption rates and capacities.
Niederer, J. P. M., Versteeg, G. F.
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Lipid Nanoparticles in Drug Delivery: Overcoming Challenges and Unlocking New Frontiers
Small Structures, Volume 7, Issue 3, March 2026.Lipid nanoparticles (LNPs) have revolutionized nucleic acid delivery, yet challenges in formulation, stability, and targeted efficacy persist. This review explores how advances in microfluidic manufacturing, precision targeting, and endosomal escape are reshaping LNP design.
Jordan Kambanis +7 more
wiley +1 more source
Some Like It Hot, Some Like It Warm: Phenotyping To Explore Thermotolerance Diversity [PDF]
, 2012 Plants have evolved overlapping but distinct cellular responses to different aspects of high temperature stress. These responses include basal thermotolerance, short- and long-term acquired thermotolerance, and thermotolerance to moderately high ...
Charng, Y. Y. +3 more
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A Facile Protocol for C(sp2)–C(sp3) Bond Formation Reactions Toward Functionalized E3 Ligase Ligands
ChemMedChem, Volume 21, Issue 4, 25 February 2026.A robust C(sp2)–C(sp3) decarboxylative coupling strategy enables access to new CRBN ligands and degraders with improved physicochemical properties. This synthetic approach is expanding the chemical space beyond C(sp2)–N linkages, fine‐tuning proteolysis‐targeting chimera activities and unlocking previously inaccessible degrader chemotypes.
Anita Maksutova +15 more
wiley +1 more source
Candida albicans Is Resistant to Polyglutamine Aggregation and Toxicity [PDF]
, 2016 Acknowledgments We thank the Donnelly Sequencing Centre for sequencing, and Jonathan Krieger at the SikKids Proteomics, Analytics, Robotics & Chemical Biology Centre at The Hospital for Sick Children for mass spectrometry analysis. M.D.L. is supported by
Collins, Cathy +6 more
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Okaramine insecticidal alkaloids show similar activity on both exon 3c and exon 3b variants of glutamate-gated chloride channels of the larval silkworm, Bombyx mori [PDF]
, 2017 The okaramine indole alkaloids were recently shown to be more selective than ivermectin in activating the glutamate-gated chloride channels of the silkworm larvae of Bombyx mori (BmGluCls).
Furutani, S +6 more
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CuH-Catalyzed Regioselective Intramolecular Hydroamination for the Synthesis of Alkyl-Substituted Chiral Aziridines [PDF]
, 2017 This report details a general and enantioselective means for the synthesis of alkyl-substituted aziridines. This protocol offers a direct route for the synthesis of alkyl-substituted chiral aziridines from achiral starting materials.
Wang, Haoxuan +2 more
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Asian Journal of Organic Chemistry, Volume 15, Issue 2, February 2026.Simple access to alkylated 3D scaffold via oxidative radical decarboxylation, trapping of iminium, and successive reaction with organometallic reagent in the presence of BF3 . ABSTRACT Cyclic amines are vital scaffolds in bioactive molecules and drug discovery, often functionalized via electrochemical Shono‐type oxidation to access N‐acyliminium ...
Dario Corbisiero +7 more
wiley +1 more source