Results 211 to 220 of about 8,323 (256)

Reduction of N-substituted azetidin-2-ones to azetidines

Australian Journal of Chemistry, 1983
Reduction of N-substituted azetidin-2-ones to N-substituted azetidines was accomplished rapidlyand in good yield with diborane in tetrahydrofuran and with alane in ether. The stereochemistryof the ring substituents was retained under the reaction conditions.
MB Jackson, LN Mander, TM Spotswood
openaire   +1 more source

Azetidines and their applications in asymmetric catalysis

, 2021
Since the early 1990s asymmetric catalytic applications of chiral, azetidine-derived, ligands and organocatalysts have been developed and utilised to engender asymmetry in reactions including Friedel-Crafts alkylations, Henry reactions and Michael-type ...
J. Milton, J. Fossey
semanticscholar   +1 more source

Alkyl Azetidines Via Batch and Flow Photochemistry.

Organic Letters
Alkyl azetidines have been prepared by photochemical modifications of azetidine-2-carboxylic acids in batch and in flow. The reaction has been realized in milligram, gram, and even multigram quantities.
Oleksandr P Datsenko, Andrii Baziievskyi, I. Sadkova, Bismarck Campos, James T. Brewster, J. Kowalski, R. Hinklin, Pavel K. Mykhailiuk   +7 more
semanticscholar   +1 more source

Monocyclic Azetidines via a Visible-Light-Mediated Aza Paternò-Büchi Reaction of Ketone-Derived Sulfonylimines.

Journal of the American Chemical Society
The recent rise in popularity of azetidines in pharmaceutical chemistry has inspired the development of visible-light-mediated aza Paternò-Büchi reactions as direct transformations to form these desirable products.
Cody H. Ng, E. Wearing, D. E. Blackmun, Gianmarco G. Terrones, Jéssica Toigo, Ka-Ming Tong, Kaid C. Harper, Julia C. Donovan, Madeleine A Gonley, E. Voight, Benjamin D Bergstrom, M. O. Wolf, Heather J. Kulik, C. Schindler   +13 more
semanticscholar   +1 more source

Rhodium-Catalyzed One-Carbon Ring Expansion of Aziridines with Vinyl-N-triftosylhydrazones for the Synthesis of 2-Vinyl Azetidines.

Angewandte Chemie
Azetidines, being four-membered N-heterocycles, possess significant potential in contemporary medicinal chemistry owing to their favorable pharmacokinetic properties.
Yongquan Ning, Hongzhu Chen, Yongyue Ning, Jin Zhang, Xihe Bi   +4 more
semanticscholar   +1 more source

Modular Synthesis of 3,3-Disubstituted Azetidines via Azetidinylation Reagents.

Journal of Organic Chemistry
Azetidines represent an attractive and emerging design option in medicinal chemistry owing to their small size and polar nature, as well as their potential to significantly impact the physicochemical properties of drug molecules.
Xin-Ru Wang, Yingying Zhang
semanticscholar   +1 more source

Synthesis of 2,2,4,4-tetramethyl-azetidine

Experientia, 1970
La 2, 2,4,4-tetrametil-azetidina (XI), e stata preparata per la prima volta con ottime rese, a partire da 2, 2, 5, 5-tetrametil-3-pirrolidone (I), attraverso i seguenti intermedi: 1-benzoil-2, 2, 5, 5-tetrametil-3-pirrolidone (II), 1-benzoil-2, 2, 5, 5-tetrametil-3, 4-pirrolidindione (III), acido 1-benzoil-3-idrossi-2, 2, 4, 4-tetrametil-3-azetidin ...
L, Dall'Asta, A, Pedrazzoli
openaire   +2 more sources

Aza-ortho-Quinone Methide Promoted Strain-Release-Driven Conversion of Azabicyclo[1.1.0]butanes into Functionalized Azetidines.

Organic Letters
A strategy for activating azabicyclo[1.1.0]butane (ABB) with in situ generated aza-ortho-quinone methide, promoted by HFIP, is reported. This unified activation, vis-à-vis strain-release-driven N/C3-functionalization, features a new means to prepare ...
Bandana Singh, Pujan Sasmal, Aaron Taites, Subhadeep Hazra, Jaideep Saha   +4 more
semanticscholar   +1 more source

A Synthetic Route to Tetrahydro-1H-azepino[4,3,2-cd]indoles via Ring-Opening Cyclization of Activated Azetidines with 4-Bromoindole: Toward a Vasopressin V2 Receptor Antagonist.

Journal of Organic Chemistry
A simple one-pot, two-step strategy for the synthesis of tetrahydro-1H-azepino[4,3,2-cd]indoles via Lewis acid-catalyzed SN2-type ring opening of activated azetidines with 4-bromoindole, followed by a Pd-catalyzed intramolecular C-N cyclization reaction,
Gaurav Goswami, Bharat Singh, I. Wani, Abhijit Mal, M. Ghorai   +4 more
semanticscholar   +1 more source

ChemInform Abstract: Synthesis of Azetidine from 1‐Substituted Azetidin‐3‐ols.

ChemInform, 1987
AbstractThe azetidinols (I) are converted into the azetidines (III) via the mesylates (II).
Y. NITTA, Y. KANAMORI
openaire   +1 more source