Results 141 to 150 of about 236,434 (328)

Adaptive Elastin‐Like Hydrogel with Unidirectional and Controllable Anisotropic Actuation for Soft Robotics and Tissue Engineering

open access: yesAdvanced Materials Technologies, EarlyView.
Fiber‐reinforced elastin‐like tubular scaffolds are engineered to achieve anisotropic and reversible actuation under external stimuli. By adjusting fiber's angle, actuation behavior is finely tuned, enabling distinct actuation responses, even within different regions of the same scaffold.
Federica Sallustio   +7 more
wiley   +1 more source

Copper-Catalyzed Synthesis of 4-CF3-1,2,3-Triazoles: An Efficient and Facile Approach via Click Reaction

open access: yesMolecules
Incorporation of a trifluoromethyl group with 1,2,3-triazoles motifs was described. We explored a click reaction approach for regioselective synthesis of 1-susbstituted-4-trifluoromethyl-1,2,3-triazoles in which 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU ...
Tinghong Tang   +5 more
doaj   +1 more source

Improving the Photochemical Skeletal Enlargement of Pyridines to 1,2‐Diazepines with Isocyanates

open access: yesAdvanced Synthesis &Catalysis, Volume 367, Issue 5, March 4, 2025.
Abstract In this work, we extend the one‐pot protocol to synthesize 1,2‐diazepines from commercially available and cheap starting materials. Capitalizing on isocyanate derivatives as activating agents, the photochemical skeletal enlargement occurs, while preserving key functional groups embedded in more than 30 substrates.
Clément Ghiazza   +3 more
wiley   +1 more source

Chemoselective Synthesis of α‐Chloro and α,α‐Dichloro Acetamidines via the Carbenoids Addition to Inherently Low Electrophilic Carbodiimides

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Carbodiimides act as competent electrophilic synthons for the chemoselective addition of lithium mono‐ and di‐halocarbenoids. The transformation is provided through a single synthetic operation—hitherto elusive—halogenated acetamidines. Interestingly, the constitutively tamed electrophilicity of the starting materials is effectively counterbalanced by ...
Davide Castiglione   +4 more
wiley   +1 more source

Electrochemical Chemo‐ and Regioselective Heterofunctionalization of Tropones via C(sp2)H Derivatization

open access: yesAdvanced Synthesis &Catalysis, EarlyView.
Simple and selective. The electrochemical heterofunctionalization of activated tropones is achieved using readily available inorganic salts. A theoretical model, based on cyclic voltammetry and quantum chemistry calculations, predicts both reactivity trends and site selectivity.
Mauro Garbini   +8 more
wiley   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

open access: yesAdvanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang   +14 more
wiley   +1 more source

Topoisomerase I Inhibition in ETV4‐overexpressed Non‐Small Cell Lung Cancer Promotes Replication and Transcription Mediated R‐Loop Accumulation and DNA Damage

open access: yesAdvanced Science, EarlyView.
The oncogenic ETS factor ETV4 exerts a pleiotropic control over DNA replication both in a transcription‐dependent and ‐independent fashion in NSCLC cells. High‐ETV4 expression leads to R‐loop formation and DNA damage in response to TOP1 inhibition.
Jiaxi Zhang   +14 more
wiley   +1 more source

A CMTM6 Nanobody Overcomes EGFR‐TKI Resistance in Non‐Small Cell Lung Cancer

open access: yesAdvanced Science, EarlyView.
Overcoming EGFR‐TKI resistance remains a critical challenge in NSCLC treatment. This study identifies CMTM6 as a key regulator of EGFR stability and demonstrates that a novel anti‐CMTM6 nanobody disrupts the CMTM6‐EGFR interaction. Targeting CMTM6 restores EGFR degradation, suppresses tumor growth, and confers therapeutic benefit in both CDX and PDX ...
Lu Xia   +18 more
wiley   +1 more source

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