Results 171 to 180 of about 227,350 (349)
Advanced Science, EarlyView.Meisoindigo targets PKMYT1 for degradation by acting as a molecular glue that enhances PKMYT1‐TRIM25 interaction, leading to K48‐linked ubiquitination and subsequent proteasomal degradation, thereby exerting therapeutic effects in chronic myeloid leukemia.
Zhao‐Xin Zhang +10 more
wiley +1 more source
CHANGES IN THE INTERNAL CARBOHYDRATES OF BEECH MYCORRHIZAS DURING TREATMENT WITH AZIDE [PDF]
, 1958 David Jennings
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Advanced Science, EarlyView.This study presents receptor‐biased IL‐2 PEGylates that selectively modulate IL‐2 receptor subunit interactions to enhance CD8⁺ T cell antitumor activity while curbing Treg activation and endothelial toxicity. The combined not‐α and not‐β variants balance immune stimulation and prevent T cell exhaustion, offering a novel, fine‐tuned approach for ...
Jiaqi Sun +23 more
wiley +1 more source
A Study of the Fungistatic and Fungicidal Properties and of the Toxicity for Mice of Sodium Azide [PDF]
, 1944 James A. Herrick, J. E. Kempf
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Advanced Science, EarlyView.MeCP2 lactylation protects against ischemic stroke by reducing brain infarct volume and improving neurological outcomes. Lactylation at K210/K249 exerts neuroprotective effects by repressing the transcription of apoptosis‐associated genes, including Pdcd4 and Pla2g6. HDAC3 and p300 serve as key regulatory enzymes for MeCP2 lactylation following stroke.
Min Sun +13 more
wiley +1 more source
Advanced Science, EarlyView.The urotropine is selected as the A‐site cation in PEMs, and four urotropine‐based PEMs ([C6H14N4][M(ClO4)3]) are successfully prepared. Compared with the cubic PEMs, the crystal structure of the urotropine‐based PEMs has an expansion along the c‐axis.
Shiyong Chen +10 more
wiley +1 more source
The Iodine-Azide Reaction. III. The Catalytic Effect of the Pentathionate Ion. [PDF]
, 1950 Niels Hofman-Bang +3 more
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Advanced Science, EarlyView.Enzymatic introduction of azido‐sialic acid residues to the glycans on exosomes enables a new and efficient approach for exosomal functionalization with various probes, including biotin and fluorophores, by biocompatible click chemistry, thereby facilitating detailed investigations of exosomes, such as their glycan profiles, cellular uptake, etc., and ...
Sayan Kundu +5 more
wiley +1 more source
Hydrazide und Azide organischer Säuren. XV. Abhandlung. Die Hydrazide der m‐ und p‐Brombenzoësäure [PDF]
, 1898 Th. Curtius, E. Portner
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