Results 221 to 230 of about 210,123 (350)

Molecular Glue Degraders of TEM β‐Lactamases by Periplasmic Protease DegP

Angewandte Chemie, EarlyView.
Molecular glues are developed that target TEM‐family β‐lactamases to the bacterial protease DegP for degradation. β‐Lactamase inhibitor tazobactam is identified as accelerating TEM β‐lactamase degradation by DegP, which is further enhanced by linkerless incorporation of dipeptides enriched among DegP substrates.
Emilia K. Taylor, Patricia Santos Barbosa, Tarini Kadambi, Frederik Eisele, Yiqiao Wang, Elisabete C. C. M. Moura, Timothy R. Walsh, Georgia L. Isom, Thomas Lanyon‐Hogg   +8 more
wiley   +1 more source

Ruthenium-catalyzed azide-alkyne cycloaddition: scope and mechanism.

Journal of the American Chemical Society, 2008
Brant C. Boren, S. Narayan, L. Rasmussen, Li Zhang, Haitao Zhao, Zhen-Yang Lin, G. Jia, V. Fokin   +7 more
semanticscholar   +1 more source

Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)

Angewandte Chemie, EarlyView.
Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley   +1 more source

A Clickable Phospholipid Platform for Ultra-Fast and Preferential Azide Labeling of Cancer Cells and Antibody Recruitment. [PDF]

Cells
Gonzales L, Antoine-Brunet T, Beauvais B, Flon V, Carty M, Mamputu S, Schlichter A, Vertueux S, Haefele A, Bailly L, Petit E, Besson T, Renard PY, Berthet N, Balieu S.   +14 more
europepmc   +1 more source

Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie

Angewandte Chemie, EarlyView.
Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean, Nicolás Montesdeoca, Gilles Berger, Johannes Karges   +3 more
wiley   +1 more source

Phage-Selected Clickable Gln-Donor Peptide for Lys-Selective Fab Labeling Using Engineered Microbial Transglutaminase. [PDF]

Antibodies (Basel)
Agustriana E, Murozono K, Minamihata K, Nishioka R, Kamiya N.   +4 more
europepmc   +1 more source

An Azide‐Modified Nucleoside for Metabolic Labeling of DNA

ChemBioChem, 2014
Anne B. Neef, N. Luedtke
semanticscholar   +1 more source