Results 221 to 230 of about 227,214 (300)

Synthetic Strategies for Activity‐Based Probes to Decode Ubiquitin‐Like Modifiers

Chemistry – A European Journal, EarlyView.
ABSTRACT Ubiquitin‐like proteins (Ubls) such as SUMO, NEDD8, ISG15, URM1, UFM1, FAT10, ATG8/ATG12, and FUBI are essential regulators of cellular homeostasis, controlling processes from protein stability and trafficking to immune signaling and autophagy.
Saibal Chanda, Alan Pham, SreeNidhi Karnati, Natalia Soto Rodriguez, Alyssa Toner, Wenshe Ray Liu   +5 more
wiley   +1 more source

Methane Catalytic Amidation via a Plausible Copper-Nitrene Intermediate. [PDF]

J Am Chem Soc
Martínez-Laguna J, Cholewinska A, Borrego E, Besora M, Álvarez M, Caballero A, Pérez PJ.   +6 more
europepmc   +1 more source

Modular Rh‐Catalyzed Synthesis and Biological Profiling of Diverse Pentafluorobenzenesulfonamide Reactive Fragments

Chemistry – A European Journal, EarlyView.
A modular Rh‐catalyzed synthetic approach enabled the preparation of diverse reactive fragments from available substrates. The reactive fragments modified Aurora A kinase via several distinct modification reaction classes. In a complex biological environment, the constellation of modified proteins depended critically on the reactive fragment structure.
Julian Chesti, Jennifer A. Miles, George J. Wade, Scott Grossman, George W. Preston, Richard Bayliss, Stuart L. Warriner, Megan H. Wright, Adam Nelson   +8 more
wiley   +1 more source

Endocyclic Trisubstituted Hydroxylamine Isosteres of Basic Amines for ADME Modulation and Reduction of hERG Activity. [PDF]

ACS Med Chem Lett
Khan I, Hettikankanamalage AA, Cui Y, Crich D.   +3 more
europepmc   +1 more source

Iridium Complexes of a Triazole‐Derived Pincer Ligand: Synthesis, Reactivity, and Transfer Dehydrogenation Catalysis

Chemistry – A European Journal, EarlyView.
Ir pincer complexes bearing a triazole architecture in the pincer backbone and O‐ancillary chelating ligands are presented. These were employed in the catalytic transfer dehydrogenation of alkanes as well as of saturated heterocycles. Reactivity of these complexes with silver salts and Lewis acids produced various cationic iridium complexes.
Jesvita Cardozo, Ouchan He, Aaron Prenzlow, Xinyang Peng, Kallol Ray, Thomas Braun   +5 more
wiley   +1 more source

Click Capture SELEX for the Identification of Click‐Modified Aptamers Targeting Small Molecules in Solution

Chemistry – A European Journal, EarlyView.
Using kanamycin A as a model target, we developed click‐capture SELEX to identify nucleobase‐modified aptamers capable of binding small molecules in solution. This approach enables flexible incorporation of nucleobase modifications via CuAAC, allowing the chemical properties of the aptamer to be tailored to the target molecule.
Philipp Menke, Carmelo Di Primo, Felix Bernhardt, Alea Schröder, Christian Renzl, Günter Mayer   +5 more
wiley   +1 more source

Synthesis and Antiproliferative Activity of Fluorinated <i>N</i>-Acetylmannosamine Analogs. [PDF]

J Org Chem
Krčil A, Šutvajová L, Hamala V, Císařová I, Kurfiřt M, Červenková Št'astná L, Bernášková J, Hrstka R, Karban J.   +8 more
europepmc   +1 more source

Self‐Immolative Gels: Programmable Degradation Using Self‐Immolative Linkers and Polymers

Chemistry – A European Journal, EarlyView.
Self‐immolative linkers and polymers undergo bond‐cleaving reaction cascades in response to specific stimuli. Their incorporation into gels can be harnessed to release cargo, induce property changes, or trigger degradation in a highly controlled manner. These functions can be employed in applications such as sensing and drug delivery.
Chuanfeng Li, Elizabeth R. Gillies
wiley   +1 more source

Cone <i>p</i>-aminocalix[4]arenes enriched with 'clickable' alkyne or azide functionalities. [PDF]

Beilstein J Org Chem
Korniltsev I, Bazhenov V, Gorbunov A, Cheshkov D, Bezzubov S, Kovalev V, Vatsouro I.   +6 more
europepmc   +1 more source

When Light Challenges Heat: Mechanistic Insights Into a Reaction Competing With Cadogan Cyclisation in Nitro‐Perylenediimides

Chemistry – A European Journal, EarlyView.
Visible‐light irradiation of nitro‐perylenediimide in the presence of triphenylphosphine reveals an unexpected pathway competing with the classical Cadogan cyclization. Mechanistic investigations uncover the rapid and selective formation of bay‐functionalized 1‐iminophosphorane‐12‐hydroxy perylenediimide derivatives.
Manuel Pedrón Laserna, Ilaria Ciofini, Piétrick Hudhomme   +2 more
wiley   +1 more source