Results 211 to 220 of about 210,123 (350)

The Cu(I)-catalyzed Huisgen azide-alkyne 1,3-dipolar cycloaddition reaction in nucleoside, nucleotide and oligonucleotide chemistry

Chemical Reviews, 2009
F. Amblard, Jong-Hyun Cho, R. Schinazi
semanticscholar   +1 more source

Astrocyte SMN Restoration and Forskolin Treatment Improve SMA Synaptic Pathology

Annals of Neurology, EarlyView.
Objective Early phenotypic presentation of central afferent synapse dysfunction within patients with spinal muscular atrophy (SMA) represents a key target for therapeutic development; however, the underlying disease mechanisms remain unresolved. By further investigating motor neuron synapse and peri‐synaptic astrocyte process (PAP) defects in human SMA
Emily Welby, Xiaojie Liu, Melinda Wojtkiewicz, Linda Berg Luecke, Rebekah L. Gundry, Qing‐Song Liu, Allison D. Ebert   +6 more
wiley   +1 more source

Synthesis of Macrocyclic Structures by Intramolecular Photoclick Reaction. [PDF]

J Am Chem Soc
Sharma S, Foster P, Molnar C, Badenhorst R, Minko S, Popik VV.   +5 more
europepmc   +1 more source

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition.

Journal of the American Chemical Society, 2003
A. Speers, G. Adam, B. Cravatt
semanticscholar   +1 more source

Chemical Inhibition of Pyocyanin Biosynthesis Attenuates Virulence of Pseudomonas aeruginosa

Angewandte Chemie, EarlyView.
Anti‐virulence strategies disarm pathogens rather than killing them directly. A β‐lactone reduces pyocyanin production without affecting growth. Chemical proteomics identified PqsC as the primary target via binding to Cys129. Crystallography revealed the binding mode, and SAR yielded a chloroacetamide inhibitor with improved enzymatic potency and anti ...
Wei Ding, Sebastian R. Borgert, Wulf Blankenfeldt, Stephan A. Sieber   +3 more
wiley   +1 more source

Active Metal Template Synthesis of Rotaxanes From BINOL‐Phosphate Macrocycles

Angewandte Chemie, EarlyView.
The use of macrocyclic BINOL‐phosphates allows for the active metal template synthesis of [2]rotaxanes via Cu(I)‐mediated alkyne‐azide cycloaddition. DFT calculations, control experiments, and kinetic experiments support a dinuclear phosphate‐Cu2 intermediate.
Nikolai Brodt, Sophia Stadtfeld, Somayyeh Kheirjou, Tibor Schumski, Adrian M. Bialowons, Dennis Jansen, Felix Niemeyer, Torsten Schaller, Gebhard Haberhauer, Jan Riebe, Jochen Niemeyer   +10 more
wiley   +1 more source

Imaging bacterial peptidoglycan with near-infrared fluorogenic azide probes

Proceedings of the National Academy of Sciences of the United States of America, 2014
P. Shieh, M. Siegrist, Andrew J. Cullen, C. Bertozzi   +3 more
semanticscholar   +1 more source

ACTIONS OF SODIUM AZIDE [PDF]

British Journal of Pharmacology and Chemotherapy, 1949
openaire   +3 more sources

Tailoring stimuli-responsive copolymers <i>via</i> a universal poly(glycidyl methacrylate) modification strategy. [PDF]

RSC Adv
Heinz S, Glößner V, Gallei M.
europepmc   +1 more source

Access to Unsupported Iminobismuthane and Tetraazabismole Species Enabled by a Rigid and Bulky Organobismuthinidene

Angewandte Chemie, EarlyView.
By employing a sterically bulky monocoordinate bismuthinidene, the synthesis and characterization of the first examples of an unsupported iminobismuthane and tetraazabismole was achieved via reactions with organic azides. The corresponding amines could be accessed by reduction, leading to the regeneration of the Bi(I) compound. Hence, we also highlight
Marcel Potocnik, Kristian L. Mears, Davide Spinnato, Gabriele Deplano, Nils Nöthling, Markus Leutzsch, Maurice van Gastel, Khai‐Nghi Truong, Serena DeBeer, Josep Cornella   +9 more
wiley   +1 more source