Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)
Angewandte Chemie, EarlyView.Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley +1 more source
Aktivierung von Metallkomplexen durch Ultraschallwellen für eine gezielte Krebstherapie
Angewandte Chemie, EarlyView.Ultrasound enables non‐invasive activation of metal‐based therapeutics deep within tumors. Acoustic cavitation can drive sonodynamic reactive oxygen species generation or mechanochemical metal–ligand bond dissociation, enabling controlled release of bioactive payloads.
Félix Grosjean +3 more
wiley +1 more source
A Chemical Framework for Engineering Extracellular Vesicles' Biointerface to Advance Precision Therapeutics. [PDF]
Adv MaterPourtalebi Jahromi L +3 more
europepmc +1 more source
Generalizable Strategies for the Synthesis of Cereblon‐Recruiting PROTAC Prodrugs
Angewandte Chemie, EarlyView.Cereblon‐recruiting PROTACs remain challenging to derivatize for prodrug‐based delivery. In this study, three complementary conjugation strategies enabled the efficient synthesis of cleavable PROTAC prodrugs with tunable release kinetics that can be incorporated into a library of PEGylated constructs and bottlebrush prodrugs.
Aiden X. Wang +7 more
wiley +1 more source
ShimNetV2-RM Neural Network for Post-Acquisition Correction of Spectral Lineshapes in NMR Reaction Monitoring. [PDF]
Magn Reson ChemJopa S, Bukowicki M, Kazimierczuk K.
europepmc +1 more source
Angewandte Chemie, EarlyView.Die direkte Umwandlung von Alkoholen in tertiäre oder sekundäre Amine in einem Reaktionsschritt unter Verwendung von Nms‐Amiden wird beschrieben. Die Transformation zeichnet sich durch eine breite Toleranz gegenüber verschiedenen funktionellen Gruppen und eine hohe Stereospezifität aus, was ihre Eignung für die Synthese isotopenmarkierter Arzneimittel ...
Jakub Brześkiewicz +3 more
wiley +1 more source
Room-Temperature Aqueous Synthesis of Copper Nanoparticles and Their In Situ Conversion to Copper Azides. [PDF]
Micromachines (Basel)Leng C +7 more
europepmc +1 more source
Evidence for a Cu(II)‐Catalysed CuAAC Reaction: A Combined Experimental and Computational Study
Angewandte Chemie, EarlyView.A new mechanistic pathway for the CuAAC reaction has been found to operate under specific reaction conditions. The pathway is catalysed by Cu(II) through a self‐assembled dinuclear Cu(II) complex that incorporates the triazole product. Computational analysis and assessment of generality are reported.
Matthew J. Andrews +12 more
wiley +1 more source
Mutations that confer resistance to sodium azide affect the levels of two physiological isoforms of SecA in <i>Escherichia coli</i>. [PDF]
Microbiology (Reading)Jiang C +5 more
europepmc +1 more source
Ein Ruthenium(CAAC‐5)‐Olefin‐Metathese‐Katalysator für die Biokonjugation
Angewandte Chemie, EarlyView.Die Instabilität von Rutheniumkatalysatoren in wässrigen Lösungen schränkt die Olefinmetathese in biologischen Medien ein. Es wird über einen Ru(CAAC‐5)‐Komplex berichtet, der unter biologisch relevanten Bedingungen aktiv bleibt und die Biokonjugation mit Proteinen, Peptiden und einem künstlichen Metalloenzym ermöglicht.
Damian Alexander Graf +4 more
wiley +1 more source